Peroxisome assembly protein 22 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P39718 (PEX22_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Peroxisome assembly protein 22

Alternative name(s):
Peroxin-22

Gene names

Name:	PEX22
Ordered Locus Names:	YAL055W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in peroxisome biogenesis By similarity.
Subcellular location	Peroxisome membrane; Single-pass membrane protein By similarity.
Miscellaneous	Present with 259 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the peroxin-22 family.

Ontologies

Keywords
Biological process	Peroxisome biogenesis
Cellular component	Membrane Peroxisome
Domain	Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein import into peroxisome matrix, receptor recycling Inferred from mutant phenotype PubMed 17452527. Source: SGD
Cellular_component	integral to peroxisomal membrane Inferred from sequence or structural similarity Ref.4. Source: SGD
Molecular_function	protein anchor Inferred from sequence or structural similarity Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 180

180

Peroxisome assembly protein 22

PRO_0000058339

Regions

Transmembrane

15 – 32

Helical; Potential

Secondary structure

180

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P39718 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 2D2E34BB93F756EF
Show »

FASTA

180

19,877

        10         20         30         40         50         60 
MPPPSRSRIN KTRTLGIVGT AIAVLVTSYY IYQKVTSAKE DNGARPPEGD SVKENKKARK 

        70         80         90        100        110        120 
SKCIIMSKSI QGLPIKWEEY AADEVVLLVP TSHTDGSMKQ AIGDAFRKTK NEHKIIYCDS 

       130        140        150        160        170        180 
MDGLWSCVRR LGKFQCILNS RDFTSSGGSD AAVVPEDIGR FVKFVVDSDV EDVLIDTLCN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane." Koller A., Snyder W.B., Faber K.N., Wenzel T.J., Rangell L., Keller G.A., Subramani S. J. Cell Biol. 146:99-112(1999) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS PEX22.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U12980 Genomic DNA. Translation: AAC04978.1.
AY558167 Genomic DNA. Translation: AAS56493.1.
BK006935 Genomic DNA. Translation: DAA06933.1.

PIR

S51966.

RefSeq

NP_009346.1. NM_001178198.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2Y9M	X-ray	2.60	B	54-180	[»]
2Y9O	X-ray	3.23	B	54-180	[»]
2Y9P	X-ray	3.25	B	54-180	[»]

ProteinModelPortal

P39718.

SMR

P39718. Positions 57-180.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-2791N.

IntAct

P39718. 3 interactions.

MINT

MINT-737360.

STRING

4932.YAL055W.

Proteomic databases

PaxDb

P39718.

PeptideAtlas

P39718.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YAL055W; YAL055W; YAL055W.

GeneID

851244.

KEGG

sce:YAL055W.

Organism-specific databases

CYGD

YAL055w.

SGD

S000000051. PEX22.

Phylogenomic databases

eggNOG

NOG84784.

OrthoDB

EOG4D567K.

Gene expression databases

Genevestigator

P39718.

GermOnline

YAL055W. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR024359. Peroxin-22.
[Graphical view]

Pfam

PF12827. Peroxin-22. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

968177.

Entry information

Entry name

PEX22_YEAST

Accession

Primary (citable) accession number: P39718
Secondary accession number(s): D6VPG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents