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P39718 (PEX22_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisome assembly protein 22
Alternative name(s):
Peroxin-22
Gene names
Name:PEX22
Ordered Locus Names:YAL055W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in peroxisome biogenesis By similarity.

Subcellular location

Peroxisome membrane; Single-pass membrane protein By similarity.

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the peroxin-22 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PEX4P2934010EBI-20707,EBI-19784

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 180180Peroxisome assembly protein 22
PRO_0000058339

Regions

Transmembrane15 – 3218Helical; Potential

Secondary structure

................................. 180
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P39718 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 2D2E34BB93F756EF

FASTA18019,877
        10         20         30         40         50         60 
MPPPSRSRIN KTRTLGIVGT AIAVLVTSYY IYQKVTSAKE DNGARPPEGD SVKENKKARK 

        70         80         90        100        110        120 
SKCIIMSKSI QGLPIKWEEY AADEVVLLVP TSHTDGSMKQ AIGDAFRKTK NEHKIIYCDS 

       130        140        150        160        170        180 
MDGLWSCVRR LGKFQCILNS RDFTSSGGSD AAVVPEDIGR FVKFVVDSDV EDVLIDTLCN 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane."
Koller A., Snyder W.B., Faber K.N., Wenzel T.J., Rangell L., Keller G.A., Subramani S.
J. Cell Biol. 146:99-112(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS PEX22.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12980 Genomic DNA. Translation: AAC04978.1.
AY558167 Genomic DNA. Translation: AAS56493.1.
BK006935 Genomic DNA. Translation: DAA06933.1.
PIRS51966.
RefSeqNP_009346.1. NM_001178198.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2Y9MX-ray2.60B54-180[»]
2Y9PX-ray3.25B54-180[»]
4BWFX-ray3.23B54-180[»]
ProteinModelPortalP39718.
SMRP39718. Positions 57-180.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31774. 56 interactions.
DIPDIP-2791N.
IntActP39718. 4 interactions.
MINTMINT-737360.
STRING4932.YAL055W.

Protein family/group databases

TCDB3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBP39718.
PaxDbP39718.
PeptideAtlasP39718.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL055W; YAL055W; YAL055W.
GeneID851244.
KEGGsce:YAL055W.

Organism-specific databases

CYGDYAL055w.
SGDS000000051. PEX22.

Phylogenomic databases

eggNOGNOG84784.
OrthoDBEOG76HQF4.

Enzyme and pathway databases

BioCycYEAST:G3O-28859-MONOMER.

Gene expression databases

GenevestigatorP39718.

Family and domain databases

InterProIPR024359. Peroxin-22.
[Graphical view]
PfamPF12827. Peroxin-22. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968177.

Entry information

Entry namePEX22_YEAST
AccessionPrimary (citable) accession number: P39718
Secondary accession number(s): D6VPG3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references