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P39718

- PEX22_YEAST

UniProt

P39718 - PEX22_YEAST

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Protein

Peroxisome assembly protein 22

Gene

PEX22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in peroxisome biogenesis.By similarity

GO - Molecular functioni

  1. protein anchor Source: SGD
  2. ubiquitin-protein transferase activator activity Source: SGD

GO - Biological processi

  1. protein import into peroxisome matrix, receptor recycling Source: SGD
  2. protein targeting to peroxisome Source: SGD
  3. regulation of catalytic activity Source: GOC
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-28859-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 22
Alternative name(s):
Peroxin-22
Gene namesi
Name:PEX22
Ordered Locus Names:YAL055W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL055w.
SGDiS000000051. PEX22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3218HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Peroxisome assembly protein 22PRO_0000058339Add
BLAST

Proteomic databases

MaxQBiP39718.
PaxDbiP39718.
PeptideAtlasiP39718.

Expressioni

Gene expression databases

GenevestigatoriP39718.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX4P2934010EBI-20707,EBI-19784

Protein-protein interaction databases

BioGridi31774. 56 interactions.
DIPiDIP-2791N.
IntActiP39718. 4 interactions.
MINTiMINT-737360.
STRINGi4932.YAL055W.

Structurei

Secondary structure

1
180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi62 – 654Combined sources
Helixi68 – 714Combined sources
Helixi77 – 793Combined sources
Turni80 – 823Combined sources
Beta strandi83 – 908Combined sources
Turni91 – 933Combined sources
Beta strandi94 – 974Combined sources
Helixi100 – 1078Combined sources
Turni108 – 1103Combined sources
Helixi112 – 1143Combined sources
Beta strandi115 – 1195Combined sources
Helixi121 – 13111Combined sources
Beta strandi134 – 1385Combined sources
Helixi140 – 1423Combined sources
Beta strandi145 – 1484Combined sources
Helixi151 – 1533Combined sources
Helixi158 – 1603Combined sources
Beta strandi163 – 1675Combined sources
Helixi171 – 1799Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Y9MX-ray2.60B54-180[»]
2Y9PX-ray3.25B54-180[»]
4BWFX-ray3.23B54-180[»]
ProteinModelPortaliP39718.
SMRiP39718. Positions 57-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-22 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84784.
InParanoidiP39718.
OrthoDBiEOG76HQF4.

Family and domain databases

InterProiIPR024359. Peroxin-22.
[Graphical view]
PfamiPF12827. Peroxin-22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39718-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPPSRSRIN KTRTLGIVGT AIAVLVTSYY IYQKVTSAKE DNGARPPEGD
60 70 80 90 100
SVKENKKARK SKCIIMSKSI QGLPIKWEEY AADEVVLLVP TSHTDGSMKQ
110 120 130 140 150
AIGDAFRKTK NEHKIIYCDS MDGLWSCVRR LGKFQCILNS RDFTSSGGSD
160 170 180
AAVVPEDIGR FVKFVVDSDV EDVLIDTLCN
Length:180
Mass (Da):19,877
Last modified:February 1, 1995 - v1
Checksum:i2D2E34BB93F756EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04978.1.
AY558167 Genomic DNA. Translation: AAS56493.1.
BK006935 Genomic DNA. Translation: DAA06933.1.
PIRiS51966.
RefSeqiNP_009346.1. NM_001178198.1.

Genome annotation databases

EnsemblFungiiYAL055W; YAL055W; YAL055W.
GeneIDi851244.
KEGGisce:YAL055W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04978.1 .
AY558167 Genomic DNA. Translation: AAS56493.1 .
BK006935 Genomic DNA. Translation: DAA06933.1 .
PIRi S51966.
RefSeqi NP_009346.1. NM_001178198.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Y9M X-ray 2.60 B 54-180 [» ]
2Y9P X-ray 3.25 B 54-180 [» ]
4BWF X-ray 3.23 B 54-180 [» ]
ProteinModelPortali P39718.
SMRi P39718. Positions 57-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31774. 56 interactions.
DIPi DIP-2791N.
IntActi P39718. 4 interactions.
MINTi MINT-737360.
STRINGi 4932.YAL055W.

Protein family/group databases

TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBi P39718.
PaxDbi P39718.
PeptideAtlasi P39718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL055W ; YAL055W ; YAL055W .
GeneIDi 851244.
KEGGi sce:YAL055W.

Organism-specific databases

CYGDi YAL055w.
SGDi S000000051. PEX22.

Phylogenomic databases

eggNOGi NOG84784.
InParanoidi P39718.
OrthoDBi EOG76HQF4.

Enzyme and pathway databases

BioCyci YEAST:G3O-28859-MONOMER.

Miscellaneous databases

NextBioi 968177.

Gene expression databases

Genevestigatori P39718.

Family and domain databases

InterProi IPR024359. Peroxin-22.
[Graphical view ]
Pfami PF12827. Peroxin-22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane."
    Koller A., Snyder W.B., Faber K.N., Wenzel T.J., Rangell L., Keller G.A., Subramani S.
    J. Cell Biol. 146:99-112(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS PEX22.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX22_YEAST
AccessioniPrimary (citable) accession number: P39718
Secondary accession number(s): D6VPG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3