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Protein

Peroxisome assembly protein 22

Gene

PEX22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in peroxisome biogenesis.By similarity

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein membrane anchor Source: SGD
  • ubiquitin-protein transferase activator activity Source: SGD

GO - Biological processi

  • positive regulation of protein autoubiquitination Source: SGD
  • positive regulation of protein ubiquitination Source: SGD
  • protein import into peroxisome matrix, receptor recycling Source: SGD
  • protein targeting to peroxisome Source: SGD

Keywordsi

Biological processPeroxisome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-28859-MONOMER

Protein family/group databases

TCDBi3.A.20.1.5 the peroxisomal protein importer (ppi) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 22
Alternative name(s):
Peroxin-22
Gene namesi
Name:PEX22
Ordered Locus Names:YAL055W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL055W
SGDiS000000051 PEX22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 32HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000583391 – 180Peroxisome assembly protein 22Add BLAST180

Proteomic databases

MaxQBiP39718
PaxDbiP39718
PRIDEiP39718

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX4P2934010EBI-20707,EBI-19784

GO - Molecular functioni

  • protein membrane anchor Source: SGD

Protein-protein interaction databases

BioGridi31774, 203 interactors
DIPiDIP-2791N
IntActiP39718, 4 interactors
MINTiP39718
STRINGi4932.YAL055W

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi62 – 65Combined sources4
Helixi68 – 71Combined sources4
Helixi77 – 79Combined sources3
Turni80 – 82Combined sources3
Beta strandi83 – 90Combined sources8
Turni91 – 93Combined sources3
Beta strandi94 – 97Combined sources4
Helixi100 – 107Combined sources8
Turni108 – 110Combined sources3
Helixi112 – 114Combined sources3
Beta strandi115 – 119Combined sources5
Helixi121 – 131Combined sources11
Beta strandi134 – 138Combined sources5
Helixi140 – 142Combined sources3
Beta strandi145 – 148Combined sources4
Helixi151 – 153Combined sources3
Helixi158 – 160Combined sources3
Beta strandi163 – 167Combined sources5
Helixi171 – 179Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y9MX-ray2.60B54-180[»]
2Y9PX-ray3.25B54-180[»]
4BWFX-ray3.23B54-180[»]
ProteinModelPortaliP39718
SMRiP39718
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-22 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP39718
OrthoDBiEOG092C5X19

Family and domain databases

Gene3Di3.40.50.11730, 1 hit
InterProiView protein in InterPro
IPR024359 Peroxin-22
IPR038613 Peroxin-22_C_sf
PfamiView protein in Pfam
PF12827 Peroxin-22, 1 hit

Sequencei

Sequence statusi: Complete.

P39718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPSRSRIN KTRTLGIVGT AIAVLVTSYY IYQKVTSAKE DNGARPPEGD
60 70 80 90 100
SVKENKKARK SKCIIMSKSI QGLPIKWEEY AADEVVLLVP TSHTDGSMKQ
110 120 130 140 150
AIGDAFRKTK NEHKIIYCDS MDGLWSCVRR LGKFQCILNS RDFTSSGGSD
160 170 180
AAVVPEDIGR FVKFVVDSDV EDVLIDTLCN
Length:180
Mass (Da):19,877
Last modified:February 1, 1995 - v1
Checksum:i2D2E34BB93F756EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA Translation: AAC04978.1
AY558167 Genomic DNA Translation: AAS56493.1
BK006935 Genomic DNA Translation: DAA06933.1
PIRiS51966
RefSeqiNP_009346.1, NM_001178198.1

Genome annotation databases

EnsemblFungiiYAL055W; YAL055W; YAL055W
GeneIDi851244
KEGGisce:YAL055W

Similar proteinsi

Entry informationi

Entry nameiPEX22_YEAST
AccessioniPrimary (citable) accession number: P39718
Secondary accession number(s): D6VPG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

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