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Protein

Peroxisome assembly protein 22

Gene

PEX22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in peroxisome biogenesis.By similarity

GO - Molecular functioni

  • protein anchor Source: SGD
  • ubiquitin-protein transferase activator activity Source: SGD

GO - Biological processi

  • positive regulation of protein autoubiquitination Source: SGD
  • positive regulation of protein ubiquitination Source: SGD
  • protein import into peroxisome matrix, receptor recycling Source: SGD
  • protein targeting to peroxisome Source: SGD
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-28859-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 22
Alternative name(s):
Peroxin-22
Gene namesi
Name:PEX22
Ordered Locus Names:YAL055W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL055W.
SGDiS000000051. PEX22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 32HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000583391 – 180Peroxisome assembly protein 22Add BLAST180

Proteomic databases

MaxQBiP39718.
PRIDEiP39718.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX4P2934010EBI-20707,EBI-19784

GO - Molecular functioni

  • protein anchor Source: SGD

Protein-protein interaction databases

BioGridi31774. 57 interactors.
DIPiDIP-2791N.
IntActiP39718. 4 interactors.
MINTiMINT-737360.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi62 – 65Combined sources4
Helixi68 – 71Combined sources4
Helixi77 – 79Combined sources3
Turni80 – 82Combined sources3
Beta strandi83 – 90Combined sources8
Turni91 – 93Combined sources3
Beta strandi94 – 97Combined sources4
Helixi100 – 107Combined sources8
Turni108 – 110Combined sources3
Helixi112 – 114Combined sources3
Beta strandi115 – 119Combined sources5
Helixi121 – 131Combined sources11
Beta strandi134 – 138Combined sources5
Helixi140 – 142Combined sources3
Beta strandi145 – 148Combined sources4
Helixi151 – 153Combined sources3
Helixi158 – 160Combined sources3
Beta strandi163 – 167Combined sources5
Helixi171 – 179Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y9MX-ray2.60B54-180[»]
2Y9PX-ray3.25B54-180[»]
4BWFX-ray3.23B54-180[»]
ProteinModelPortaliP39718.
SMRiP39718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-22 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP39718.
OrthoDBiEOG092C5X19.

Family and domain databases

InterProiIPR024359. Peroxin-22.
[Graphical view]
PfamiPF12827. Peroxin-22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPSRSRIN KTRTLGIVGT AIAVLVTSYY IYQKVTSAKE DNGARPPEGD
60 70 80 90 100
SVKENKKARK SKCIIMSKSI QGLPIKWEEY AADEVVLLVP TSHTDGSMKQ
110 120 130 140 150
AIGDAFRKTK NEHKIIYCDS MDGLWSCVRR LGKFQCILNS RDFTSSGGSD
160 170 180
AAVVPEDIGR FVKFVVDSDV EDVLIDTLCN
Length:180
Mass (Da):19,877
Last modified:February 1, 1995 - v1
Checksum:i2D2E34BB93F756EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04978.1.
AY558167 Genomic DNA. Translation: AAS56493.1.
BK006935 Genomic DNA. Translation: DAA06933.1.
PIRiS51966.
RefSeqiNP_009346.1. NM_001178198.1.

Genome annotation databases

EnsemblFungiiYAL055W; YAL055W; YAL055W.
GeneIDi851244.
KEGGisce:YAL055W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04978.1.
AY558167 Genomic DNA. Translation: AAS56493.1.
BK006935 Genomic DNA. Translation: DAA06933.1.
PIRiS51966.
RefSeqiNP_009346.1. NM_001178198.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y9MX-ray2.60B54-180[»]
2Y9PX-ray3.25B54-180[»]
4BWFX-ray3.23B54-180[»]
ProteinModelPortaliP39718.
SMRiP39718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31774. 57 interactors.
DIPiDIP-2791N.
IntActiP39718. 4 interactors.
MINTiMINT-737360.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBiP39718.
PRIDEiP39718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL055W; YAL055W; YAL055W.
GeneIDi851244.
KEGGisce:YAL055W.

Organism-specific databases

EuPathDBiFungiDB:YAL055W.
SGDiS000000051. PEX22.

Phylogenomic databases

InParanoidiP39718.
OrthoDBiEOG092C5X19.

Enzyme and pathway databases

BioCyciYEAST:G3O-28859-MONOMER.

Miscellaneous databases

PROiP39718.

Family and domain databases

InterProiIPR024359. Peroxin-22.
[Graphical view]
PfamiPF12827. Peroxin-22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX22_YEAST
AccessioniPrimary (citable) accession number: P39718
Secondary accession number(s): D6VPG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.