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P39718

- PEX22_YEAST

UniProt

P39718 - PEX22_YEAST

Protein

Peroxisome assembly protein 22

Gene

PEX22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in peroxisome biogenesis.By similarity

    GO - Molecular functioni

    1. protein anchor Source: SGD
    2. protein binding Source: IntAct
    3. ubiquitin-protein transferase activator activity Source: SGD

    GO - Biological processi

    1. protein import into peroxisome matrix, receptor recycling Source: SGD
    2. protein targeting to peroxisome Source: SGD
    3. regulation of catalytic activity Source: GOC

    Keywords - Biological processi

    Peroxisome biogenesis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28859-MONOMER.

    Protein family/group databases

    TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisome assembly protein 22
    Alternative name(s):
    Peroxin-22
    Gene namesi
    Name:PEX22
    Ordered Locus Names:YAL055W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL055w.
    SGDiS000000051. PEX22.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of peroxisomal membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 180180Peroxisome assembly protein 22PRO_0000058339Add
    BLAST

    Proteomic databases

    MaxQBiP39718.
    PaxDbiP39718.
    PeptideAtlasiP39718.

    Expressioni

    Gene expression databases

    GenevestigatoriP39718.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PEX4P2934010EBI-20707,EBI-19784

    Protein-protein interaction databases

    BioGridi31774. 56 interactions.
    DIPiDIP-2791N.
    IntActiP39718. 4 interactions.
    MINTiMINT-737360.
    STRINGi4932.YAL055W.

    Structurei

    Secondary structure

    1
    180
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi62 – 654
    Helixi68 – 714
    Helixi77 – 793
    Turni80 – 823
    Beta strandi83 – 908
    Turni91 – 933
    Beta strandi94 – 974
    Helixi100 – 1078
    Turni108 – 1103
    Helixi112 – 1143
    Beta strandi115 – 1195
    Helixi121 – 13111
    Beta strandi134 – 1385
    Helixi140 – 1423
    Beta strandi145 – 1484
    Helixi151 – 1533
    Helixi158 – 1603
    Beta strandi163 – 1675
    Helixi171 – 1799

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2Y9MX-ray2.60B54-180[»]
    2Y9PX-ray3.25B54-180[»]
    4BWFX-ray3.23B54-180[»]
    ProteinModelPortaliP39718.
    SMRiP39718. Positions 57-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3218HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peroxin-22 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG84784.
    OrthoDBiEOG76HQF4.

    Family and domain databases

    InterProiIPR024359. Peroxin-22.
    [Graphical view]
    PfamiPF12827. Peroxin-22. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39718-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPPSRSRIN KTRTLGIVGT AIAVLVTSYY IYQKVTSAKE DNGARPPEGD    50
    SVKENKKARK SKCIIMSKSI QGLPIKWEEY AADEVVLLVP TSHTDGSMKQ 100
    AIGDAFRKTK NEHKIIYCDS MDGLWSCVRR LGKFQCILNS RDFTSSGGSD 150
    AAVVPEDIGR FVKFVVDSDV EDVLIDTLCN 180
    Length:180
    Mass (Da):19,877
    Last modified:February 1, 1995 - v1
    Checksum:i2D2E34BB93F756EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC04978.1.
    AY558167 Genomic DNA. Translation: AAS56493.1.
    BK006935 Genomic DNA. Translation: DAA06933.1.
    PIRiS51966.
    RefSeqiNP_009346.1. NM_001178198.1.

    Genome annotation databases

    EnsemblFungiiYAL055W; YAL055W; YAL055W.
    GeneIDi851244.
    KEGGisce:YAL055W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC04978.1 .
    AY558167 Genomic DNA. Translation: AAS56493.1 .
    BK006935 Genomic DNA. Translation: DAA06933.1 .
    PIRi S51966.
    RefSeqi NP_009346.1. NM_001178198.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2Y9M X-ray 2.60 B 54-180 [» ]
    2Y9P X-ray 3.25 B 54-180 [» ]
    4BWF X-ray 3.23 B 54-180 [» ]
    ProteinModelPortali P39718.
    SMRi P39718. Positions 57-180.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31774. 56 interactions.
    DIPi DIP-2791N.
    IntActi P39718. 4 interactions.
    MINTi MINT-737360.
    STRINGi 4932.YAL055W.

    Protein family/group databases

    TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Proteomic databases

    MaxQBi P39718.
    PaxDbi P39718.
    PeptideAtlasi P39718.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL055W ; YAL055W ; YAL055W .
    GeneIDi 851244.
    KEGGi sce:YAL055W.

    Organism-specific databases

    CYGDi YAL055w.
    SGDi S000000051. PEX22.

    Phylogenomic databases

    eggNOGi NOG84784.
    OrthoDBi EOG76HQF4.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28859-MONOMER.

    Miscellaneous databases

    NextBioi 968177.

    Gene expression databases

    Genevestigatori P39718.

    Family and domain databases

    InterProi IPR024359. Peroxin-22.
    [Graphical view ]
    Pfami PF12827. Peroxin-22. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane."
      Koller A., Snyder W.B., Faber K.N., Wenzel T.J., Rangell L., Keller G.A., Subramani S.
      J. Cell Biol. 146:99-112(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS PEX22.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPEX22_YEAST
    AccessioniPrimary (citable) accession number: P39718
    Secondary accession number(s): D6VPG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 259 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3