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P39715

- ECM1_YEAST

UniProt

P39715 - ECM1_YEAST

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Protein
Shuttling pre-60S factor ECM1
Gene
ECM1, SIM1, YAL059W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Pre-ribosomal factor involved in 60S ribosomal protein subunit export from the nucleus.2 Publications

GO - Biological processi

  1. ribosomal large subunit export from nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28862-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Shuttling pre-60S factor ECM1
Alternative name(s):
Extracellular mutant protein 1
Protein SIM1
Gene namesi
Name:ECM1
Synonyms:SIM1
Ordered Locus Names:YAL059W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL059w.
SGDiS000000055. ECM1.

Subcellular locationi

Nucleusnucleolus. Nucleus. Cytoplasm
Note: Shuttles between the nucleus and the cytoplasm and is re-imported by the KAP123 karyopherin.3 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: SGD
  3. nucleus Source: SGD
  4. preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Shuttling pre-60S factor ECM1
PRO_0000086916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei188 – 1881Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39715.
PaxDbiP39715.
PeptideAtlasiP39715.

Expressioni

Gene expression databases

GenevestigatoriP39715.

Interactioni

Subunit structurei

Associates with the pre-60S ribosomal particle and the nucleopore complex.

Protein-protein interaction databases

BioGridi31771. 65 interactions.
DIPiDIP-2465N.
IntActiP39715. 21 interactions.
MINTiMINT-621124.
STRINGi4932.YAL059W.

Family & Domainsi

Sequence similaritiesi

Belongs to the ECM1 family.

Phylogenomic databases

eggNOGiNOG44019.
HOGENOMiHOG000094086.
OMAiQCVISAK.
OrthoDBiEOG7F255B.

Family and domain databases

InterProiIPR022784. Ribosome_bgen_Alb1.
[Graphical view]
PfamiPF09135. Alb1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39715-1 [UniParc]FASTAAdd to Basket

« Hide

MWEQRRQKVV FSLTILVRYR LKQSMAKKIS KNSRAARQSD ALEPEVKDLS    50
ELPRAEKTDL TNILIRTAAK NEALLEAKIS KKANKSKRGK KLNKKALEDK 100
LANSISSMDR DRLVKALNFT NRLDGKIAKS ISRAKYIQNT RKAGWDSTNE 150
TIKKELAFLN GGLSVQAKSA SEGNAEKEDE EIPEVFDSLA EDNTVQKTPT 200
NRFGVLPDDV EE 212
Length:212
Mass (Da):23,891
Last modified:July 27, 2011 - v2
Checksum:iACFFE6CFF6F62CD5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021A → D in AAC04975. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12980 Genomic DNA. Translation: AAC04975.1.
AY558168 Genomic DNA. Translation: AAS56494.1.
BK006935 Genomic DNA. Translation: DAA06930.2.
PIRiS51963.
RefSeqiNP_009342.2. NM_001178201.2.

Genome annotation databases

EnsemblFungiiYAL059W; YAL059W; YAL059W.
GeneIDi851240.
KEGGisce:YAL059W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12980 Genomic DNA. Translation: AAC04975.1 .
AY558168 Genomic DNA. Translation: AAS56494.1 .
BK006935 Genomic DNA. Translation: DAA06930.2 .
PIRi S51963.
RefSeqi NP_009342.2. NM_001178201.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31771. 65 interactions.
DIPi DIP-2465N.
IntActi P39715. 21 interactions.
MINTi MINT-621124.
STRINGi 4932.YAL059W.

Proteomic databases

MaxQBi P39715.
PaxDbi P39715.
PeptideAtlasi P39715.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL059W ; YAL059W ; YAL059W .
GeneIDi 851240.
KEGGi sce:YAL059W.

Organism-specific databases

CYGDi YAL059w.
SGDi S000000055. ECM1.

Phylogenomic databases

eggNOGi NOG44019.
HOGENOMi HOG000094086.
OMAi QCVISAK.
OrthoDBi EOG7F255B.

Enzyme and pathway databases

BioCyci YEAST:G3O-28862-MONOMER.

Miscellaneous databases

NextBioi 968168.

Gene expression databases

Genevestigatori P39715.

Family and domain databases

InterProi IPR022784. Ribosome_bgen_Alb1.
[Graphical view ]
Pfami PF09135. Alb1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 102.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Identification of a 60S preribosomal particle that is closely linked to nuclear export."
    Bassler J., Grandi P., Gadal O., Lessmann T., Petfalski E., Tollervey D., Lechner J., Hurt E.
    Mol. Cell 8:517-529(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Ecm1 is a new pre-ribosomal factor involved in pre-60S particle export."
    Yao Y., Demoinet E., Saveanu C., Lenormand P., Jacquier A., Fromont-Racine M.
    RNA 16:1007-1017(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH THE PRE-60S PARTICLE AND THE NUCLEOPORE COMPLEX.

Entry informationi

Entry nameiECM1_YEAST
AccessioniPrimary (citable) accession number: P39715
Secondary accession number(s): D6VPG0, E9P8V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: May 14, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2840 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

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