Reviewed,
UniProtKB/Swiss-Prot P39714 (BDH1_YEAST)
Last modified
November 25, 2008.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: (R,R)-butanediol dehydrogenase EC=1.1.1.4 | ||||||||
| Gene names |
| ||||||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 382 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | (R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + NADH. |
| Cofactor | Binds 2 zinc ions per subunit By similarity. |
| Subunit structure | Homodimer. |
| Miscellaneous | Present with 8730 molecules/cell in log phase SD medium. |
| Sequence similarities | Belongs to the zinc-containing alcohol dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Ligand | Metal-binding NAD Zinc |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | cellular alcohol metabolic process Ref.2 Inferred from mutant phenotype. Source: SGD oxidation reductionInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from direct assay. Source: SGD |
| Molecular function | (R,R)-butanediol dehydrogenase activity Ref.2 Inferred from electronic annotation. Source: EC protein bindingInferred from physical interaction. Source: IntAct zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 382 | 382 | (R,R)-butanediol dehydrogenase | PRO_0000160788 | |||||
Sites | |||||||||
| Metal binding | 39 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 73 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 103 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 120 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 123 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 131 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 173 | 1 | Zinc 1; catalytic By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed: 7731988] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [2] | "Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene." Gonzalez E., Fernandez M.R., Larroy C., Sola L., Pericas M.A., Pares X., Biosca J.A. J. Biol. Chem. 275:35876-35885(2000) [PubMed: 10938079] [Abstract] Cited for: CHARACTERIZATION. Strain: ATCC 90845 / FY834. |
| [3] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U12980 Genomic DNA. Translation: AAC04974.1. | |
| PIR | S51962. |
| RefSeq | NP_009341.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1E3J based on UniProtKB O96496. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:5356N. |
| IntAct | P39714. |
Proteomic databases | |
| PeptideAtlas | P39714. |
Genome annotation databases | |
| Ensembl | YAL060W. Saccharomyces cerevisiae. [Contig view] |
| GeneID | 851239. |
| GenomeReviews | Gene locus YAL060W in contig U00091_GR. |
| KEGG | sce:YAL060W. |
| NMPDR | fig|4932.3.peg.15. |
Organism-specific databases | |
| CYGD | YAL060w. |
| SGD | S000000056. BDH1. |
| Yeast-GFP | Search... |
Phylogenomic databases | |
| HOGENOM | P39714. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MON-14023. |
Gene expression databases | |
| GermOnline | YAL060W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view] |
| PANTHER | PTHR11695. ADH_Sf_Zn. 1 hit. |
| Pfam | PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view] |
| PROSITE | PS00059. ADH_ZINC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | P39714. |
| NextBio | 968165. |
Entry information
| Entry name | BDH1_YEAST | ||||||||
| Accession | Primary (citable) accession number: P39714 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome I Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names |

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