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P39713

- BDH2_YEAST

UniProt

P39713 - BDH2_YEAST

Protein

Probable diacetyl reductase [(R)-acetoin forming] 2

Gene

BDH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH.Curated

    Catalytic activityi

    (R)-acetoin + NAD+ = diacetyl + NADH.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi39 – 391Zinc 1; catalyticBy similarity
    Metal bindingi64 – 641Zinc 1; catalyticBy similarity
    Metal bindingi120 – 1201Zinc 2By similarity
    Metal bindingi123 – 1231Zinc 2By similarity
    Metal bindingi131 – 1311Zinc 2By similarity
    Metal bindingi173 – 1731Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. diacetyl reductase ((R)-acetoin forming) activity Source: UniProtKB-EC
    2. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: SGD
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28863-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable diacetyl reductase [(R)-acetoin forming] 2 (EC:1.1.1.303)
    Gene namesi
    Name:BDH2
    Ordered Locus Names:YAL061W
    ORF Names:FUN50
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL061w.
    SGDiS000000057. BDH2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Probable diacetyl reductase [(R)-acetoin forming] 2PRO_0000160897Add
    BLAST

    Proteomic databases

    MaxQBiP39713.
    PaxDbiP39713.

    Expressioni

    Inductioni

    Expression is controlled by the PDR1 transcription factor and the glucose-responsive transcription factor RGT1.2 Publications

    Gene expression databases

    GenevestigatoriP39713.

    Interactioni

    Protein-protein interaction databases

    BioGridi31769. 8 interactions.
    DIPiDIP-6734N.
    IntActiP39713. 2 interactions.
    MINTiMINT-641070.
    STRINGi4932.YAL061W.

    Structurei

    3D structure databases

    ProteinModelPortaliP39713.
    SMRiP39713. Positions 1-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1063.
    GeneTreeiENSGT00750000118226.
    HOGENOMiHOG000294670.
    KOiK00004.
    OMAiHTHEISH.
    OrthoDBiEOG7DVDNZ.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.
    PROSITEiPS00059. ADH_ZINC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39713-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRALAYFGKG NIRFTNHLKE PHIVAPDELV IDIEWCGICG TDLHEYTDGP    50
    IFFPEDGHTH EISHNPLPQA MGHEMAGTVL EVGPGVKNLK VGDKVVVEPT 100
    GTCRDRYRWP LSPNVDKEWC AACKKGYYNI CSYLGLCGAG VQSGGFAERV 150
    VMNESHCYKV PDFVPLDVAA LIQPLAVCWH AIRVCEFKAG STALIIGAGP 200
    IGLGTILALN AAGCKDIVVS EPAKVRRELA EKMGARVYDP TAHAAKESID 250
    YLRSIADGGD GFDYTFDCSG LEVTLNAAIQ CLTFRGTAVN LAMWGHHKIQ 300
    FSPMDITLHE RKYTGSMCYT HHDFEAVIEA LEEGRIDIDR ARHMITGRVN 350
    IEDGLDGAIM KLINEKESTI KIILTPNNHG ELNREADNEK KEISELSSRK 400
    DQERLRESIN EAKLRHT 417
    Length:417
    Mass (Da):46,099
    Last modified:February 1, 1995 - v1
    Checksum:iD921CEDBE61D0151
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC04973.1.
    AY692730 Genomic DNA. Translation: AAT92749.1.
    BK006935 Genomic DNA. Translation: DAA06928.1.
    PIRiS51961.
    RefSeqiNP_009340.1. NM_001178203.1.

    Genome annotation databases

    EnsemblFungiiYAL061W; YAL061W; YAL061W.
    GeneIDi851238.
    KEGGisce:YAL061W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC04973.1 .
    AY692730 Genomic DNA. Translation: AAT92749.1 .
    BK006935 Genomic DNA. Translation: DAA06928.1 .
    PIRi S51961.
    RefSeqi NP_009340.1. NM_001178203.1.

    3D structure databases

    ProteinModelPortali P39713.
    SMRi P39713. Positions 1-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31769. 8 interactions.
    DIPi DIP-6734N.
    IntActi P39713. 2 interactions.
    MINTi MINT-641070.
    STRINGi 4932.YAL061W.

    Proteomic databases

    MaxQBi P39713.
    PaxDbi P39713.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL061W ; YAL061W ; YAL061W .
    GeneIDi 851238.
    KEGGi sce:YAL061W.

    Organism-specific databases

    CYGDi YAL061w.
    SGDi S000000057. BDH2.

    Phylogenomic databases

    eggNOGi COG1063.
    GeneTreei ENSGT00750000118226.
    HOGENOMi HOG000294670.
    KOi K00004.
    OMAi HTHEISH.
    OrthoDBi EOG7DVDNZ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28863-MONOMER.

    Miscellaneous databases

    NextBioi 968162.

    Gene expression databases

    Genevestigatori P39713.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    PROSITEi PS00059. ADH_ZINC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs."
      do Valle Matta M.A., Jonniaux J.-L., Balzi E., Goffeau A., van den Hazel B.
      Gene 272:111-119(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Regulatory network connecting two glucose signal transduction pathways in Saccharomyces cerevisiae."
      Kaniak A., Xue Z., Macool D., Kim J.-H., Johnston M.
      Eukaryot. Cell 3:221-231(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiBDH2_YEAST
    AccessioniPrimary (citable) accession number: P39713
    Secondary accession number(s): D6VPF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3090 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3