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Protein

Probable diacetyl reductase [(R)-acetoin forming] 2

Gene

BDH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH.Curated

Miscellaneous

Present with 3090 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

(R)-acetoin + NAD+ = diacetyl + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39Zinc 1; catalyticBy similarity1
Metal bindingi64Zinc 1; catalyticBy similarity1
Metal bindingi120Zinc 2By similarity1
Metal bindingi123Zinc 2By similarity1
Metal bindingi131Zinc 2By similarity1
Metal bindingi173Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-28863-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable diacetyl reductase [(R)-acetoin forming] 2 (EC:1.1.1.303)
Gene namesi
Name:BDH2
Ordered Locus Names:YAL061W
ORF Names:FUN50
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL061W.
SGDiS000000057. BDH2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001608971 – 417Probable diacetyl reductase [(R)-acetoin forming] 2Add BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39713.
PRIDEiP39713.

Expressioni

Inductioni

Expression is controlled by the PDR1 transcription factor and the glucose-responsive transcription factor RGT1.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi31769. 124 interactors.
DIPiDIP-6734N.
IntActiP39713. 2 interactors.
MINTiMINT-641070.
STRINGi4932.YAL061W.

Structurei

3D structure databases

ProteinModelPortaliP39713.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00890000140269.
HOGENOMiHOG000294670.
InParanoidiP39713.
KOiK00004.
OMAiRCAPLTI.
OrthoDBiEOG092C3CGE.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P39713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALAYFGKG NIRFTNHLKE PHIVAPDELV IDIEWCGICG TDLHEYTDGP
60 70 80 90 100
IFFPEDGHTH EISHNPLPQA MGHEMAGTVL EVGPGVKNLK VGDKVVVEPT
110 120 130 140 150
GTCRDRYRWP LSPNVDKEWC AACKKGYYNI CSYLGLCGAG VQSGGFAERV
160 170 180 190 200
VMNESHCYKV PDFVPLDVAA LIQPLAVCWH AIRVCEFKAG STALIIGAGP
210 220 230 240 250
IGLGTILALN AAGCKDIVVS EPAKVRRELA EKMGARVYDP TAHAAKESID
260 270 280 290 300
YLRSIADGGD GFDYTFDCSG LEVTLNAAIQ CLTFRGTAVN LAMWGHHKIQ
310 320 330 340 350
FSPMDITLHE RKYTGSMCYT HHDFEAVIEA LEEGRIDIDR ARHMITGRVN
360 370 380 390 400
IEDGLDGAIM KLINEKESTI KIILTPNNHG ELNREADNEK KEISELSSRK
410
DQERLRESIN EAKLRHT
Length:417
Mass (Da):46,099
Last modified:February 1, 1995 - v1
Checksum:iD921CEDBE61D0151
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA. Translation: AAC04973.1.
AY692730 Genomic DNA. Translation: AAT92749.1.
BK006935 Genomic DNA. Translation: DAA06928.1.
PIRiS51961.
RefSeqiNP_009340.1. NM_001178203.1.

Genome annotation databases

EnsemblFungiiYAL061W; YAL061W; YAL061W.
GeneIDi851238.
KEGGisce:YAL061W.

Similar proteinsi

Entry informationi

Entry nameiBDH2_YEAST
AccessioniPrimary (citable) accession number: P39713
Secondary accession number(s): D6VPF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: August 30, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names