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P39713 (BDH2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable diacetyl reductase [(R)-acetoin forming] 2

EC=1.1.1.303
Gene names
Name:BDH2
Ordered Locus Names:YAL061W
ORF Names:FUN50
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH Potential.

Catalytic activity

(R)-acetoin + NAD+ = diacetyl + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subcellular location

Cytoplasm. Nucleus Ref.5.

Induction

Expression is controlled by the PDR1 transcription factor and the glucose-responsive transcription factor RGT1. Ref.4 Ref.7

Miscellaneous

Present with 3090 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Probable diacetyl reductase [(R)-acetoin forming] 2
PRO_0000160897

Sites

Metal binding391Zinc 1; catalytic By similarity
Metal binding641Zinc 1; catalytic By similarity
Metal binding1201Zinc 2 By similarity
Metal binding1231Zinc 2 By similarity
Metal binding1311Zinc 2 By similarity
Metal binding1731Zinc 1; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
P39713 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: D921CEDBE61D0151

FASTA41746,099
        10         20         30         40         50         60 
MRALAYFGKG NIRFTNHLKE PHIVAPDELV IDIEWCGICG TDLHEYTDGP IFFPEDGHTH 

        70         80         90        100        110        120 
EISHNPLPQA MGHEMAGTVL EVGPGVKNLK VGDKVVVEPT GTCRDRYRWP LSPNVDKEWC 

       130        140        150        160        170        180 
AACKKGYYNI CSYLGLCGAG VQSGGFAERV VMNESHCYKV PDFVPLDVAA LIQPLAVCWH 

       190        200        210        220        230        240 
AIRVCEFKAG STALIIGAGP IGLGTILALN AAGCKDIVVS EPAKVRRELA EKMGARVYDP 

       250        260        270        280        290        300 
TAHAAKESID YLRSIADGGD GFDYTFDCSG LEVTLNAAIQ CLTFRGTAVN LAMWGHHKIQ 

       310        320        330        340        350        360 
FSPMDITLHE RKYTGSMCYT HHDFEAVIEA LEEGRIDIDR ARHMITGRVN IEDGLDGAIM 

       370        380        390        400        410 
KLINEKESTI KIILTPNNHG ELNREADNEK KEISELSSRK DQERLRESIN EAKLRHT 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs."
do Valle Matta M.A., Jonniaux J.-L., Balzi E., Goffeau A., van den Hazel B.
Gene 272:111-119(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Regulatory network connecting two glucose signal transduction pathways in Saccharomyces cerevisiae."
Kaniak A., Xue Z., Macool D., Kim J.-H., Johnston M.
Eukaryot. Cell 3:221-231(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12980 Genomic DNA. Translation: AAC04973.1.
AY692730 Genomic DNA. Translation: AAT92749.1.
BK006935 Genomic DNA. Translation: DAA06928.1.
PIRS51961.
RefSeqNP_009340.1. NM_001178203.1.

3D structure databases

ProteinModelPortalP39713.
SMRP39713. Positions 1-356.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31769. 8 interactions.
DIPDIP-6734N.
IntActP39713. 2 interactions.
MINTMINT-641070.
STRING4932.YAL061W.

Proteomic databases

MaxQBP39713.
PaxDbP39713.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL061W; YAL061W; YAL061W.
GeneID851238.
KEGGsce:YAL061W.

Organism-specific databases

CYGDYAL061w.
SGDS000000057. BDH2.

Phylogenomic databases

eggNOGCOG1063.
GeneTreeENSGT00750000118226.
HOGENOMHOG000294670.
KOK00004.
OMAHTHEISH.
OrthoDBEOG7DVDNZ.

Enzyme and pathway databases

BioCycYEAST:G3O-28863-MONOMER.

Gene expression databases

GenevestigatorP39713.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968162.

Entry information

Entry nameBDH2_YEAST
AccessionPrimary (citable) accession number: P39713
Secondary accession number(s): D6VPF8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families