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P39709 (SEO1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable transporter SEO1
Gene names
Name:SEO1
Ordered Locus Names:YAL067C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Not known; suppressor of sulfoxide ethionine resistance.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Allantoate permease family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Probable transporter SEO1
PRO_0000121368

Regions

Topological domain1 – 130130Cytoplasmic Potential
Transmembrane131 – 15121Helical; Potential
Topological domain152 – 17524Extracellular Potential
Transmembrane176 – 19621Helical; Potential
Topological domain197 – 2004Cytoplasmic Potential
Transmembrane201 – 22121Helical; Potential
Topological domain222 – 23413Extracellular Potential
Transmembrane235 – 25521Helical; Potential
Topological domain256 – 26510Cytoplasmic Potential
Transmembrane266 – 28621Helical; Potential
Topological domain287 – 30216Extracellular Potential
Transmembrane303 – 32321Helical; Potential
Topological domain324 – 36340Cytoplasmic Potential
Transmembrane364 – 38421Helical; Potential
Topological domain385 – 41127Extracellular Potential
Transmembrane412 – 43221Helical; Potential
Topological domain433 – 4386Cytoplasmic Potential
Transmembrane439 – 45921Helical; Potential
Topological domain460 – 4667Extracellular Potential
Transmembrane467 – 48721Helical; Potential
Topological domain488 – 49912Cytoplasmic Potential
Transmembrane500 – 52021Helical; Potential
Topological domain521 – 53212Extracellular Potential
Transmembrane533 – 55321Helical; Potential
Topological domain554 – 59340Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P39709 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 6B7B1A2A7D5EAA44

FASTA59368,842
        10         20         30         40         50         60 
MYSIVKEIIV DPYKRLKWGF IPVKRQVEDL PDDLNSTEIV TISNSIQSHE TAENFITTTS 

        70         80         90        100        110        120 
EKDQLHFETS SYSEHKDNVN VTRSYEYRDE ADRPWWRFFD EQEYRINEKE RSHNKWYSWF 

       130        140        150        160        170        180 
KQGTSFKEKK LLIKLDVLLA FYSCIAYWVK YLDTVNINNA YVSGMKEDLG FQGNDLVHTQ 

       190        200        210        220        230        240 
VMYTVGNIIF QLPFLIYLNK LPLNYVLPSL DLCWSLLTVG AAYVNSVPHL KAIRFFIGAF 

       250        260        270        280        290        300 
EAPSYLAYQY LFGSFYKHDE MVRRSAFYYL GQYIGILSAG GIQSAVYSSL NGVNGLEGWR 

       310        320        330        340        350        360 
WNFIIDAIVS VVVGLIGFYS LPGDPYNCYS IFLTDDEIRL ARKRLKENQT GKSDFETKVF 

       370        380        390        400        410        420 
DIKLWKTIFS DWKIYILTLW NIFCWNDSNV SSGAYLLWLK SLKRYSIPKL NQLSMITPGL 

       430        440        450        460        470        480 
GMVYLMLTGI IADKLHSRWF AIIFTQVFNI IGNSILAAWD VAEGAKWFAF MLQCFGWAMA 

       490        500        510        520        530        540 
PVLYSWQNDI CRRDAQTRAI TLVTMNIMAQ SSTAWISVLV WKTEEAPRYL KGFTFTACSA 

       550        560        570        580        590 
FCLSIWTFVV LYFYKRDERN NAKKNGIVLY NSKHGVEKPT SKDVETLSVS DEK 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[4]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12980 Genomic DNA. Translation: AAC04968.1.
BK006935 Genomic DNA. Translation: DAA06920.1.
PIRS51956.
RefSeqNP_009333.1. NM_001178208.1.

3D structure databases

ProteinModelPortalP39709.
SMRP39709. Positions 163-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31762. 13 interactions.
DIPDIP-8291N.
IntActP39709. 1 interaction.
MINTMINT-1354581.
STRING4932.YAL067C.

Protein family/group databases

TCDB2.A.1.14.37. the major facilitator superfamily (mfs).

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL067C; YAL067C; YAL067C.
GeneID851230.
KEGGsce:YAL067C.

Organism-specific databases

CYGDYAL067c.
SGDS000000062. SEO1.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00620000088258.
HOGENOMHOG000179304.
OMAWKFWALL.
OrthoDBEOG7QZGKW.

Enzyme and pathway databases

BioCycYEAST:G3O-28866-MONOMER.

Gene expression databases

GenevestigatorP39709.

Family and domain databases

InterProIPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
ProtoNetSearch...

Other

NextBio968141.

Entry information

Entry nameSEO1_YEAST
AccessionPrimary (citable) accession number: P39709
Secondary accession number(s): D6VPF0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families