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P39708

- DHE5_YEAST

UniProt

P39708 - DHE5_YEAST

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Protein

NADP-specific glutamate dehydrogenase 2

Gene

GDH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 20430NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: SGD

GO - Biological processi

  1. ammonia assimilation cycle Source: SGD
  2. glutamate biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-11505.
YEAST:YAL062W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase 2 (EC:1.4.1.4)
Short name:
NADP-GDH 2
Alternative name(s):
NADP-dependent glutamate dehydrogenase 2
Gene namesi
Name:GDH3
Ordered Locus Names:YAL062W
ORF Names:FUN51
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL062w.
SGDiS000000058. GDH3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457NADP-specific glutamate dehydrogenase 2PRO_0000182799Add
BLAST

Proteomic databases

MaxQBiP39708.
PaxDbiP39708.
PeptideAtlasiP39708.
PRIDEiP39708.

Expressioni

Gene expression databases

GenevestigatoriP39708.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

BioGridi31768. 23 interactions.
DIPiDIP-4325N.
IntActiP39708. 3 interactions.
MINTiMINT-488220.
STRINGi4932.YAL062W.

Structurei

3D structure databases

ProteinModelPortaliP39708.
SMRiP39708. Positions 3-454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
GeneTreeiENSGT00390000000854.
HOGENOMiHOG000243799.
InParanoidiP39708.
KOiK00262.
OMAiTANEYEV.
OrthoDBiEOG7XSTPW.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39708-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSEPEFQQA YDEIVSSVED SKIFEKFPQY KKVLPIVSVP ERIIQFRVTW
60 70 80 90 100
ENDNGEQEVA QGYRVQFNSA KGPYKGGLRF HPSVNLSILK FLGFEQIFKN
110 120 130 140 150
ALTGLDMGGG KGGLCVDLKG KSDNEIRRIC YAFMRELSRH IGKDTDVPAG
160 170 180 190 200
DIGVGGREIG YLFGAYRSYK NSWEGVLTGK GLNWGGSLIR PEATGFGLVY
210 220 230 240 250
YTQAMIDYAT NGKESFEGKR VTISGSGNVA QYAALKVIEL GGIVVSLSDS
260 270 280 290 300
KGCIISETGI TSEQIHDIAS AKIRFKSLEE IVDEYSTFSE SKMKYVAGAR
310 320 330 340 350
PWTHVSNVDI ALPCATQNEV SGDEAKALVA SGVKFVAEGA NMGSTPEAIS
360 370 380 390 400
VFETARSTAT NAKDAVWFGP PKAANLGGVA VSGLEMAQNS QKVTWTAERV
410 420 430 440 450
DQELKKIMIN CFNDCIQAAQ EYSTEKNTNT LPSLVKGANI ASFVMVADAM

LDQGDVF
Length:457
Mass (Da):49,627
Last modified:February 1, 1995 - v1
Checksum:i81B30625038B1888
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12980 Genomic DNA. Translation: AAC04972.1.
BK006935 Genomic DNA. Translation: DAA06927.1.
PIRiS51960.
RefSeqiNP_009339.1. NM_001178204.1.

Genome annotation databases

EnsemblFungiiYAL062W; YAL062W; YAL062W.
GeneIDi851237.
KEGGisce:YAL062W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12980 Genomic DNA. Translation: AAC04972.1 .
BK006935 Genomic DNA. Translation: DAA06927.1 .
PIRi S51960.
RefSeqi NP_009339.1. NM_001178204.1.

3D structure databases

ProteinModelPortali P39708.
SMRi P39708. Positions 3-454.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31768. 23 interactions.
DIPi DIP-4325N.
IntActi P39708. 3 interactions.
MINTi MINT-488220.
STRINGi 4932.YAL062W.

Proteomic databases

MaxQBi P39708.
PaxDbi P39708.
PeptideAtlasi P39708.
PRIDEi P39708.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL062W ; YAL062W ; YAL062W .
GeneIDi 851237.
KEGGi sce:YAL062W.

Organism-specific databases

CYGDi YAL062w.
SGDi S000000058. GDH3.

Phylogenomic databases

eggNOGi COG0334.
GeneTreei ENSGT00390000000854.
HOGENOMi HOG000243799.
InParanoidi P39708.
KOi K00262.
OMAi TANEYEV.
OrthoDBi EOG7XSTPW.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-11505.
YEAST:YAL062W-MONOMER.

Miscellaneous databases

NextBioi 968159.
PROi P39708.

Gene expression databases

Genevestigatori P39708.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiDHE5_YEAST
AccessioniPrimary (citable) accession number: P39708
Secondary accession number(s): D6VPF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3