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P39708

- DHE5_YEAST

UniProt

P39708 - DHE5_YEAST

Protein

NADP-specific glutamate dehydrogenase 2

Gene

GDH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei111 – 1111PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi175 – 20430NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. glutamate dehydrogenase (NADP+) activity Source: SGD

    GO - Biological processi

    1. ammonia assimilation cycle Source: SGD
    2. glutamate biosynthetic process Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-11505.
    YEAST:YAL062W-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADP-specific glutamate dehydrogenase 2 (EC:1.4.1.4)
    Short name:
    NADP-GDH 2
    Alternative name(s):
    NADP-dependent glutamate dehydrogenase 2
    Gene namesi
    Name:GDH3
    Ordered Locus Names:YAL062W
    ORF Names:FUN51
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL062w.
    SGDiS000000058. GDH3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457NADP-specific glutamate dehydrogenase 2PRO_0000182799Add
    BLAST

    Proteomic databases

    MaxQBiP39708.
    PaxDbiP39708.
    PeptideAtlasiP39708.
    PRIDEiP39708.

    Expressioni

    Gene expression databases

    GenevestigatoriP39708.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    BioGridi31768. 23 interactions.
    DIPiDIP-4325N.
    IntActiP39708. 3 interactions.
    MINTiMINT-488220.
    STRINGi4932.YAL062W.

    Structurei

    3D structure databases

    ProteinModelPortaliP39708.
    SMRiP39708. Positions 3-454.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0334.
    GeneTreeiENSGT00390000000854.
    HOGENOMiHOG000243799.
    KOiK00262.
    OMAiTANEYEV.
    OrthoDBiEOG7XSTPW.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000185. Glu_DH. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39708-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSEPEFQQA YDEIVSSVED SKIFEKFPQY KKVLPIVSVP ERIIQFRVTW    50
    ENDNGEQEVA QGYRVQFNSA KGPYKGGLRF HPSVNLSILK FLGFEQIFKN 100
    ALTGLDMGGG KGGLCVDLKG KSDNEIRRIC YAFMRELSRH IGKDTDVPAG 150
    DIGVGGREIG YLFGAYRSYK NSWEGVLTGK GLNWGGSLIR PEATGFGLVY 200
    YTQAMIDYAT NGKESFEGKR VTISGSGNVA QYAALKVIEL GGIVVSLSDS 250
    KGCIISETGI TSEQIHDIAS AKIRFKSLEE IVDEYSTFSE SKMKYVAGAR 300
    PWTHVSNVDI ALPCATQNEV SGDEAKALVA SGVKFVAEGA NMGSTPEAIS 350
    VFETARSTAT NAKDAVWFGP PKAANLGGVA VSGLEMAQNS QKVTWTAERV 400
    DQELKKIMIN CFNDCIQAAQ EYSTEKNTNT LPSLVKGANI ASFVMVADAM 450
    LDQGDVF 457
    Length:457
    Mass (Da):49,627
    Last modified:February 1, 1995 - v1
    Checksum:i81B30625038B1888
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC04972.1.
    BK006935 Genomic DNA. Translation: DAA06927.1.
    PIRiS51960.
    RefSeqiNP_009339.1. NM_001178204.1.

    Genome annotation databases

    EnsemblFungiiYAL062W; YAL062W; YAL062W.
    GeneIDi851237.
    KEGGisce:YAL062W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12980 Genomic DNA. Translation: AAC04972.1 .
    BK006935 Genomic DNA. Translation: DAA06927.1 .
    PIRi S51960.
    RefSeqi NP_009339.1. NM_001178204.1.

    3D structure databases

    ProteinModelPortali P39708.
    SMRi P39708. Positions 3-454.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31768. 23 interactions.
    DIPi DIP-4325N.
    IntActi P39708. 3 interactions.
    MINTi MINT-488220.
    STRINGi 4932.YAL062W.

    Proteomic databases

    MaxQBi P39708.
    PaxDbi P39708.
    PeptideAtlasi P39708.
    PRIDEi P39708.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL062W ; YAL062W ; YAL062W .
    GeneIDi 851237.
    KEGGi sce:YAL062W.

    Organism-specific databases

    CYGDi YAL062w.
    SGDi S000000058. GDH3.

    Phylogenomic databases

    eggNOGi COG0334.
    GeneTreei ENSGT00390000000854.
    HOGENOMi HOG000243799.
    KOi K00262.
    OMAi TANEYEV.
    OrthoDBi EOG7XSTPW.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-11505.
    YEAST:YAL062W-MONOMER.

    Miscellaneous databases

    NextBioi 968159.
    PROi P39708.

    Gene expression databases

    Genevestigatori P39708.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000185. Glu_DH. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiDHE5_YEAST
    AccessioniPrimary (citable) accession number: P39708
    Secondary accession number(s): D6VPF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3