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P39708 (DHE5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADP-specific glutamate dehydrogenase 2

Short name=NADP-GDH 2
EC=1.4.1.4
Alternative name(s):
NADP-dependent glutamate dehydrogenase 2
Gene names
Name:GDH3
Ordered Locus Names:YAL062W
ORF Names:FUN51
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Subunit structure

Homohexamer By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457NADP-specific glutamate dehydrogenase 2
PRO_0000182799

Regions

Nucleotide binding175 – 20430NAD By similarity

Sites

Active site1111 By similarity

Sequences

Sequence LengthMass (Da)Tools
P39708 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 81B30625038B1888

FASTA45749,627
        10         20         30         40         50         60 
MTSEPEFQQA YDEIVSSVED SKIFEKFPQY KKVLPIVSVP ERIIQFRVTW ENDNGEQEVA 

        70         80         90        100        110        120 
QGYRVQFNSA KGPYKGGLRF HPSVNLSILK FLGFEQIFKN ALTGLDMGGG KGGLCVDLKG 

       130        140        150        160        170        180 
KSDNEIRRIC YAFMRELSRH IGKDTDVPAG DIGVGGREIG YLFGAYRSYK NSWEGVLTGK 

       190        200        210        220        230        240 
GLNWGGSLIR PEATGFGLVY YTQAMIDYAT NGKESFEGKR VTISGSGNVA QYAALKVIEL 

       250        260        270        280        290        300 
GGIVVSLSDS KGCIISETGI TSEQIHDIAS AKIRFKSLEE IVDEYSTFSE SKMKYVAGAR 

       310        320        330        340        350        360 
PWTHVSNVDI ALPCATQNEV SGDEAKALVA SGVKFVAEGA NMGSTPEAIS VFETARSTAT 

       370        380        390        400        410        420 
NAKDAVWFGP PKAANLGGVA VSGLEMAQNS QKVTWTAERV DQELKKIMIN CFNDCIQAAQ 

       430        440        450 
EYSTEKNTNT LPSLVKGANI ASFVMVADAM LDQGDVF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12980 Genomic DNA. Translation: AAC04972.1.
BK006935 Genomic DNA. Translation: DAA06927.1.
PIRS51960.
RefSeqNP_009339.1. NM_001178204.1.

3D structure databases

ProteinModelPortalP39708.
SMRP39708. Positions 3-454.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31768. 23 interactions.
DIPDIP-4325N.
IntActP39708. 3 interactions.
MINTMINT-488220.
STRING4932.YAL062W.

Proteomic databases

MaxQBP39708.
PaxDbP39708.
PeptideAtlasP39708.
PRIDEP39708.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL062W; YAL062W; YAL062W.
GeneID851237.
KEGGsce:YAL062W.

Organism-specific databases

CYGDYAL062w.
SGDS000000058. GDH3.

Phylogenomic databases

eggNOGCOG0334.
GeneTreeENSGT00390000000854.
HOGENOMHOG000243799.
KOK00262.
OMATANEYEV.
OrthoDBEOG7XSTPW.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-11505.
YEAST:YAL062W-MONOMER.

Gene expression databases

GenevestigatorP39708.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968159.
PROP39708.

Entry information

Entry nameDHE5_YEAST
AccessionPrimary (citable) accession number: P39708
Secondary accession number(s): D6VPF7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families