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Protein

NADP-specific glutamate dehydrogenase 2

Gene

GDH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei111PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi175 – 204NADBy similarityAdd BLAST30

GO - Molecular functioni

  • glutamate dehydrogenase (NADP+) activity Source: SGD

GO - Biological processi

  • ammonia assimilation cycle Source: SGD
  • glutamate biosynthetic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyciMetaCyc:YAL062W-MONOMER
YEAST:YAL062W-MONOMER
ReactomeiR-SCE-2151201 Transcriptional activation of mitochondrial biogenesis
R-SCE-70614 Amino acid synthesis and interconversion (transamination)

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase 2 (EC:1.4.1.4)
Short name:
NADP-GDH 2
Alternative name(s):
NADP-dependent glutamate dehydrogenase 2
Gene namesi
Name:GDH3
Ordered Locus Names:YAL062W
ORF Names:FUN51
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL062W
SGDiS000000058 GDH3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001827991 – 457NADP-specific glutamate dehydrogenase 2Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki326Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki436Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP39708
PaxDbiP39708
PRIDEiP39708

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

BioGridi31768, 54 interactors
DIPiDIP-4325N
IntActiP39708, 2 interactors
MINTiP39708
STRINGi4932.YAL062W

Structurei

3D structure databases

ProteinModelPortaliP39708
SMRiP39708
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000000854
HOGENOMiHOG000243799
InParanoidiP39708
KOiK00262
OMAiVHGANIC
OrthoDBiEOG092C2DRP

Family and domain databases

CDDicd05313 NAD_bind_2_Glu_DH, 1 hit
InterProiView protein in InterPro
IPR006095 Glu/Leu/Phe/Val_DH
IPR033524 Glu/Leu/Phe/Val_DH_AS
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom
IPR014362 Glu_DH
IPR036291 NAD(P)-bd_dom_sf
IPR033922 NAD_bind_Glu_DH
PfamiView protein in Pfam
PF00208 ELFV_dehydrog, 1 hit
PF02812 ELFV_dehydrog_N, 1 hit
PIRSFiPIRSF000185 Glu_DH, 1 hit
PRINTSiPR00082 GLFDHDRGNASE
SMARTiView protein in SMART
SM00839 ELFV_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00074 GLFV_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

P39708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSEPEFQQA YDEIVSSVED SKIFEKFPQY KKVLPIVSVP ERIIQFRVTW
60 70 80 90 100
ENDNGEQEVA QGYRVQFNSA KGPYKGGLRF HPSVNLSILK FLGFEQIFKN
110 120 130 140 150
ALTGLDMGGG KGGLCVDLKG KSDNEIRRIC YAFMRELSRH IGKDTDVPAG
160 170 180 190 200
DIGVGGREIG YLFGAYRSYK NSWEGVLTGK GLNWGGSLIR PEATGFGLVY
210 220 230 240 250
YTQAMIDYAT NGKESFEGKR VTISGSGNVA QYAALKVIEL GGIVVSLSDS
260 270 280 290 300
KGCIISETGI TSEQIHDIAS AKIRFKSLEE IVDEYSTFSE SKMKYVAGAR
310 320 330 340 350
PWTHVSNVDI ALPCATQNEV SGDEAKALVA SGVKFVAEGA NMGSTPEAIS
360 370 380 390 400
VFETARSTAT NAKDAVWFGP PKAANLGGVA VSGLEMAQNS QKVTWTAERV
410 420 430 440 450
DQELKKIMIN CFNDCIQAAQ EYSTEKNTNT LPSLVKGANI ASFVMVADAM

LDQGDVF
Length:457
Mass (Da):49,627
Last modified:February 1, 1995 - v1
Checksum:i81B30625038B1888
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA Translation: AAC04972.1
BK006935 Genomic DNA Translation: DAA06927.1
PIRiS51960
RefSeqiNP_009339.1, NM_001178204.1

Genome annotation databases

EnsemblFungiiYAL062W; YAL062W; YAL062W
GeneIDi851237
KEGGisce:YAL062W

Similar proteinsi

Entry informationi

Entry nameiDHE5_YEAST
AccessioniPrimary (citable) accession number: P39708
Secondary accession number(s): D6VPF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

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