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Protein

COMPASS component SWD1

Gene

SWD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.2 Publications

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • chromatin silencing at telomere Source: SGD
  • histone H3-K4 methylation Source: SGD
  • regulation of transcription, DNA-templated Source: SGD
  • telomere maintenance Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-28868-MONOMER
ReactomeiR-SCE-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMPASS component SWD1
Alternative name(s):
Complex proteins associated with SET1 protein SWD1
Set1C component SWD1
Gene namesi
Name:SWD1
Synonyms:CPS50, SAF49
Ordered Locus Names:YAR003W
ORF Names:FUN16
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAR003W
SGDiS000000064 SWD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512511 – 426COMPASS component SWD1Add BLAST426

Proteomic databases

MaxQBiP39706
PaxDbiP39706
PRIDEiP39706

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex which consists of SET12, BRE22, SPP12, SDC11, SHG11, SWD11, SWD21, and SWD31.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31792, 481 interactors
DIPiDIP-1753N
IntActiP39706, 22 interactors
MINTiP39706
STRINGi4932.YAR003W

Structurei

3D structure databases

ProteinModelPortaliP39706
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 63WD 1Add BLAST40
Repeati70 – 109WD 2Add BLAST40
Repeati212 – 251WD 3Add BLAST40
Repeati264 – 307WD 4Add BLAST44
Repeati310 – 350WD 5Add BLAST41

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00530000064100
HOGENOMiHOG000204856
InParanoidiP39706
KOiK14961
OMAiFRMPILF
OrthoDBiEOG092C2ZQC

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR037850 RBBP5/Swd1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR44040 PTHR44040, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P39706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILLQDPFA VLKEHPEKLT HTIENPLRTE CLQFSPCGDY LALGCANGAL
60 70 80 90 100
VIYDMDTFRP ICVPGNMLGA HVRPITSIAW SPDGRLLLTS SRDWSIKLWD
110 120 130 140 150
LSKPSKPLKE IRFDSPIWGC QWLDAKRRLC VATIFEESDA YVIDFSNDPV
160 170 180 190 200
ASLLSKSDEK QLSSTPDHGY VLVCTVHTKH PNIIIVGTSK GWLDFYKFHS
210 220 230 240 250
LYQTECIHSL KITSSNIKHL IVSQNGERLA INCSDRTIRQ YEISIDDENS
260 270 280 290 300
AVELTLEHKY QDVINKLQWN CILFSNNTAE YLVASTHGSS AHELYIWETT
310 320 330 340 350
SGTLVRVLEG AEEELIDINW DFYSMSIVSN GFESGNVYVW SVVIPPKWSA
360 370 380 390 400
LAPDFEEVEE NVDYLEKEDE FDEVDEAEQQ QGLEQEEEIA IDLRTREQYD
410 420
VRGNNLLVER FTIPTDYTRI IKMQSS
Length:426
Mass (Da):48,655
Last modified:February 1, 1995 - v1
Checksum:i90C389612AB66231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22015 Genomic DNA Translation: AAC04959.1
BK006935 Genomic DNA Translation: DAA06988.1
PIRiS40901
RefSeqiNP_009403.1, NM_001178210.1

Genome annotation databases

EnsemblFungiiYAR003W; YAR003W; YAR003W
GeneIDi851265
KEGGisce:YAR003W

Similar proteinsi

Entry informationi

Entry nameiSWD1_YEAST
AccessioniPrimary (citable) accession number: P39706
Secondary accession number(s): D6VPL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health