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P39706

- SWD1_YEAST

UniProt

P39706 - SWD1_YEAST

Protein

COMPASS component SWD1

Gene

SWD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. chromatin silencing at telomere Source: SGD
    2. histone H3-K4 methylation Source: SGD
    3. regulation of transcription, DNA-templated Source: SGD
    4. telomere maintenance Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28868-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COMPASS component SWD1
    Alternative name(s):
    Complex proteins associated with SET1 protein SWD1
    Set1C component SWD1
    Gene namesi
    Name:SWD1
    Synonyms:CPS50, SAF49
    Ordered Locus Names:YAR003W
    ORF Names:FUN16
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAR003w.
    SGDiS000000064. SWD1.

    Subcellular locationi

    Nucleus 1 Publication. Chromosometelomere 1 Publication

    GO - Cellular componenti

    1. chromosome, telomeric region Source: UniProtKB-SubCell
    2. Set1C/COMPASS complex Source: SGD

    Keywords - Cellular componenti

    Chromosome, Nucleus, Telomere

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426COMPASS component SWD1PRO_0000051251Add
    BLAST

    Proteomic databases

    MaxQBiP39706.
    PaxDbiP39706.

    Expressioni

    Gene expression databases

    GenevestigatoriP39706.

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex which consists of SET12, BRE22, SPP12, SDC11, SHG11, SWD11, SWD21, and SWD31.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SWD3P381237EBI-20737,EBI-20881

    Protein-protein interaction databases

    BioGridi31792. 246 interactions.
    DIPiDIP-1753N.
    IntActiP39706. 16 interactions.
    MINTiMINT-393563.
    STRINGi4932.YAR003W.

    Structurei

    3D structure databases

    ProteinModelPortaliP39706.
    SMRiP39706. Positions 31-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati24 – 6340WD 1Add
    BLAST
    Repeati70 – 10940WD 2Add
    BLAST
    Repeati212 – 25140WD 3Add
    BLAST
    Repeati264 – 30744WD 4Add
    BLAST
    Repeati310 – 35041WD 5Add
    BLAST

    Sequence similaritiesi

    Contains 5 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00530000064100.
    HOGENOMiHOG000204856.
    KOiK14961.
    OMAiLTHTIEN.
    OrthoDBiEOG7TXKRS.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39706-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNILLQDPFA VLKEHPEKLT HTIENPLRTE CLQFSPCGDY LALGCANGAL    50
    VIYDMDTFRP ICVPGNMLGA HVRPITSIAW SPDGRLLLTS SRDWSIKLWD 100
    LSKPSKPLKE IRFDSPIWGC QWLDAKRRLC VATIFEESDA YVIDFSNDPV 150
    ASLLSKSDEK QLSSTPDHGY VLVCTVHTKH PNIIIVGTSK GWLDFYKFHS 200
    LYQTECIHSL KITSSNIKHL IVSQNGERLA INCSDRTIRQ YEISIDDENS 250
    AVELTLEHKY QDVINKLQWN CILFSNNTAE YLVASTHGSS AHELYIWETT 300
    SGTLVRVLEG AEEELIDINW DFYSMSIVSN GFESGNVYVW SVVIPPKWSA 350
    LAPDFEEVEE NVDYLEKEDE FDEVDEAEQQ QGLEQEEEIA IDLRTREQYD 400
    VRGNNLLVER FTIPTDYTRI IKMQSS 426
    Length:426
    Mass (Da):48,655
    Last modified:February 1, 1995 - v1
    Checksum:i90C389612AB66231
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22015 Genomic DNA. Translation: AAC04959.1.
    BK006935 Genomic DNA. Translation: DAA06988.1.
    PIRiS40901.
    RefSeqiNP_009403.1. NM_001178210.1.

    Genome annotation databases

    EnsemblFungiiYAR003W; YAR003W; YAR003W.
    GeneIDi851265.
    KEGGisce:YAR003W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22015 Genomic DNA. Translation: AAC04959.1 .
    BK006935 Genomic DNA. Translation: DAA06988.1 .
    PIRi S40901.
    RefSeqi NP_009403.1. NM_001178210.1.

    3D structure databases

    ProteinModelPortali P39706.
    SMRi P39706. Positions 31-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31792. 246 interactions.
    DIPi DIP-1753N.
    IntActi P39706. 16 interactions.
    MINTi MINT-393563.
    STRINGi 4932.YAR003W.

    Proteomic databases

    MaxQBi P39706.
    PaxDbi P39706.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAR003W ; YAR003W ; YAR003W .
    GeneIDi 851265.
    KEGGi sce:YAR003W.

    Organism-specific databases

    CYGDi YAR003w.
    SGDi S000000064. SWD1.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00530000064100.
    HOGENOMi HOG000204856.
    KOi K14961.
    OMAi LTHTIEN.
    OrthoDBi EOG7TXKRS.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28868-MONOMER.

    Miscellaneous databases

    NextBioi 968231.
    PROi P39706.

    Gene expression databases

    Genevestigatori P39706.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
      Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
      Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4."
      Roguev A., Schaft D., Shevchenko A., Pijnappel W.W.M.P., Wilm M., Aasland R., Stewart A.F.
      EMBO J. 20:7137-7148(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    5. "COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression."
      Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J., Johnston M., Shilatifard A.
      J. Biol. Chem. 277:10753-10755(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: SUBUNIT.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "Localization of proteins that are coordinately expressed with Cln2 during the cell cycle."
      Sundin B.A., Chiu C.-H., Riffle M., Davis T.N., Muller E.G.D.
      Yeast 21:793-800(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSWD1_YEAST
    AccessioniPrimary (citable) accession number: P39706
    Secondary accession number(s): D6VPL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 907 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3