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P39706 (SWD1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
COMPASS component SWD1
Alternative name(s):
Complex proteins associated with SET1 protein SWD1
Set1C component SWD1
Gene names
Name:SWD1
Synonyms:CPS50, SAF49
Ordered Locus Names:YAR003W
ORF Names:FUN16
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. Ref.4 Ref.5

Subunit structure

Component of the COMPASS (Set1C) complex which consists of SET12, BRE22, SPP12, SDC11, SHG11, SWD11, SWD21, and SWD31. Ref.4 Ref.6

Subcellular location

Nucleus. Chromosometelomere Ref.8.

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.

Sequence similarities

Contains 5 WD repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SWD3P381237EBI-20737,EBI-20881

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426COMPASS component SWD1
PRO_0000051251

Regions

Repeat24 – 6340WD 1
Repeat70 – 10940WD 2
Repeat212 – 25140WD 3
Repeat264 – 30744WD 4
Repeat310 – 35041WD 5

Sequences

Sequence LengthMass (Da)Tools
P39706 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 90C389612AB66231

FASTA42648,655
        10         20         30         40         50         60 
MNILLQDPFA VLKEHPEKLT HTIENPLRTE CLQFSPCGDY LALGCANGAL VIYDMDTFRP 

        70         80         90        100        110        120 
ICVPGNMLGA HVRPITSIAW SPDGRLLLTS SRDWSIKLWD LSKPSKPLKE IRFDSPIWGC 

       130        140        150        160        170        180 
QWLDAKRRLC VATIFEESDA YVIDFSNDPV ASLLSKSDEK QLSSTPDHGY VLVCTVHTKH 

       190        200        210        220        230        240 
PNIIIVGTSK GWLDFYKFHS LYQTECIHSL KITSSNIKHL IVSQNGERLA INCSDRTIRQ 

       250        260        270        280        290        300 
YEISIDDENS AVELTLEHKY QDVINKLQWN CILFSNNTAE YLVASTHGSS AHELYIWETT 

       310        320        330        340        350        360 
SGTLVRVLEG AEEELIDINW DFYSMSIVSN GFESGNVYVW SVVIPPKWSA LAPDFEEVEE 

       370        380        390        400        410        420 
NVDYLEKEDE FDEVDEAEQQ QGLEQEEEIA IDLRTREQYD VRGNNLLVER FTIPTDYTRI 


IKMQSS 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4."
Roguev A., Schaft D., Shevchenko A., Pijnappel W.W.M.P., Wilm M., Aasland R., Stewart A.F.
EMBO J. 20:7137-7148(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[5]"COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression."
Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J., Johnston M., Shilatifard A.
J. Biol. Chem. 277:10753-10755(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"COMPASS: a complex of proteins associated with a trithorax-related SET domain protein."
Miller T., Krogan N.J., Dover J., Erdjument-Bromage H., Tempst P., Johnston M., Greenblatt J.F., Shilatifard A.
Proc. Natl. Acad. Sci. U.S.A. 98:12902-12907(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"Localization of proteins that are coordinately expressed with Cln2 during the cell cycle."
Sundin B.A., Chiu C.-H., Riffle M., Davis T.N., Muller E.G.D.
Yeast 21:793-800(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22015 Genomic DNA. Translation: AAC04959.1.
BK006935 Genomic DNA. Translation: DAA06988.1.
PIRS40901.
RefSeqNP_009403.1. NM_001178210.1.

3D structure databases

ProteinModelPortalP39706.
SMRP39706. Positions 32-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31792. 244 interactions.
DIPDIP-1753N.
IntActP39706. 16 interactions.
MINTMINT-393563.
STRING4932.YAR003W.

Proteomic databases

PaxDbP39706.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAR003W; YAR003W; YAR003W.
GeneID851265.
KEGGsce:YAR003W.

Organism-specific databases

CYGDYAR003w.
SGDS000000064. SWD1.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00530000064100.
HOGENOMHOG000204856.
KOK14961.
OMANYPEEFD.
OrthoDBEOG7TXKRS.

Enzyme and pathway databases

BioCycYEAST:G3O-28868-MONOMER.

Gene expression databases

GenevestigatorP39706.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 1 hit.
[Graphical view]
SMARTSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968231.
PROP39706.

Entry information

Entry nameSWD1_YEAST
AccessionPrimary (citable) accession number: P39706
Secondary accession number(s): D6VPL8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families