COMPASS component SWD1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P39706 (SWD1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 111. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
COMPASS component SWD1

Alternative name(s):
Complex proteins associated with SET1 protein SWD1
Set1C component SWD1

Gene names

Name:	SWD1
Synonyms:	CPS50, SAF49
Ordered Locus Names:	YAR003W
ORF Names:	FUN16

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. Ref.4 Ref.5
Subunit structure	Component of the COMPASS (Set1C) complex which consists of SET1₂, BRE2₂, SPP1₂, SDC1₁, SHG1₁, SWD1₁, SWD2₁, and SWD3₁. Ref.4 Ref.6
Subcellular location	Nucleus. Chromosome › telomere Ref.8.
Miscellaneous	Present with 907 molecules/cell in log phase SD medium.
Sequence similarities	Contains 5 WD repeats.

Ontologies

Keywords
Cellular component	Chromosome Nucleus Telomere
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin silencing at telomere Inferred from mutant phenotype Ref.6 PubMed 11752412 Ref.5. Source: SGD histone H3-K4 methylation Inferred from direct assay Ref.4 Ref.5. Source: SGD telomere maintenance Inferred from mutant phenotype Ref.4. Source: SGD
Cellular_component	Set1C/COMPASS complex Inferred from physical interaction Ref.6 Ref.4 PubMed 11752412. Source: SGD chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SWD3	P38123	7	EBI-20737,EBI-20881

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 426

426

COMPASS component SWD1

PRO_0000051251

Regions

Repeat

24 – 63

WD 1

Repeat

70 – 109

WD 2

Repeat

212 – 251

WD 3

Repeat

264 – 307

WD 4

Repeat

310 – 350

WD 5

Sequences

Sequence

Length

Mass (Da)

Tools

P39706 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 90C389612AB66231
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FASTA

426

48,655

        10         20         30         40         50         60 
MNILLQDPFA VLKEHPEKLT HTIENPLRTE CLQFSPCGDY LALGCANGAL VIYDMDTFRP 

        70         80         90        100        110        120 
ICVPGNMLGA HVRPITSIAW SPDGRLLLTS SRDWSIKLWD LSKPSKPLKE IRFDSPIWGC 

       130        140        150        160        170        180 
QWLDAKRRLC VATIFEESDA YVIDFSNDPV ASLLSKSDEK QLSSTPDHGY VLVCTVHTKH 

       190        200        210        220        230        240 
PNIIIVGTSK GWLDFYKFHS LYQTECIHSL KITSSNIKHL IVSQNGERLA INCSDRTIRQ 

       250        260        270        280        290        300 
YEISIDDENS AVELTLEHKY QDVINKLQWN CILFSNNTAE YLVASTHGSS AHELYIWETT 

       310        320        330        340        350        360 
SGTLVRVLEG AEEELIDINW DFYSMSIVSN GFESGNVYVW SVVIPPKWSA LAPDFEEVEE 

       370        380        390        400        410        420 
NVDYLEKEDE FDEVDEAEQQ QGLEQEEEIA IDLRTREQYD VRGNNLLVER FTIPTDYTRI 


IKMQSS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region." Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H. Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4." Roguev A., Schaft D., Shevchenko A., Pijnappel W.W.M.P., Wilm M., Aasland R., Stewart A.F. EMBO J. 20:7137-7148(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT.
[5]	"COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression." Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J., Johnston M., Shilatifard A. J. Biol. Chem. 277:10753-10755(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"COMPASS: a complex of proteins associated with a trithorax-related SET domain protein." Miller T., Krogan N.J., Dover J., Erdjument-Bromage H., Tempst P., Johnston M., Greenblatt J.F., Shilatifard A. Proc. Natl. Acad. Sci. U.S.A. 98:12902-12907(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"Localization of proteins that are coordinately expressed with Cln2 during the cell cycle." Sundin B.A., Chiu C.-H., Riffle M., Davis T.N., Muller E.G.D. Yeast 21:793-800(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22015 Genomic DNA. Translation: AAC04959.1. BK006935 Genomic DNA. Translation: DAA06988.1.
PIR	S40901.
RefSeq	NP_009403.1. NM_001178210.1.
3D structure databases
ProteinModelPortal	P39706.
SMR	P39706. Positions 32-342.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1753N.
IntAct	P39706. 17 interactions.
MINT	MINT-393563.
STRING	4932.YAR003W.
Proteomic databases
PaxDb	P39706.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YAR003W; YAR003W; YAR003W.
GeneID	851265.
KEGG	sce:YAR003W.
Organism-specific databases
CYGD	YAR003w.
SGD	S000000064. SWD1.
Phylogenomic databases
eggNOG	COG2319.
GeneTree	ENSGT00530000064100.
HOGENOM	HOG000204856.
KO	K14961.
OMA	VNRLQWN.
OrthoDB	EOG4PP1RS.
Gene expression databases
Genevestigator	P39706.
GermOnline	YAR003W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 2 hits. [Graphical view]
SMART	SM00320. WD40. 5 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	968231.

Entry information

Entry name

SWD1_YEAST

Accession

Primary (citable) accession number: P39706
Secondary accession number(s): D6VPL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents