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P39706

- SWD1_YEAST

UniProt

P39706 - SWD1_YEAST

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Protein

COMPASS component SWD1

Gene

SWD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.2 Publications

GO - Biological processi

  1. chromatin silencing at telomere Source: SGD
  2. histone H3-K4 methylation Source: SGD
  3. regulation of transcription, DNA-templated Source: SGD
  4. telomere maintenance Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-28868-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
COMPASS component SWD1
Alternative name(s):
Complex proteins associated with SET1 protein SWD1
Set1C component SWD1
Gene namesi
Name:SWD1
Synonyms:CPS50, SAF49
Ordered Locus Names:YAR003W
ORF Names:FUN16
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAR003w.
SGDiS000000064. SWD1.

Subcellular locationi

Nucleus 1 Publication. Chromosometelomere 1 Publication

GO - Cellular componenti

  1. chromosome, telomeric region Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426COMPASS component SWD1PRO_0000051251Add
BLAST

Proteomic databases

MaxQBiP39706.
PaxDbiP39706.

Expressioni

Gene expression databases

GenevestigatoriP39706.

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex which consists of SET12, BRE22, SPP12, SDC11, SHG11, SWD11, SWD21, and SWD31.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SWD3P381237EBI-20737,EBI-20881

Protein-protein interaction databases

BioGridi31792. 247 interactions.
DIPiDIP-1753N.
IntActiP39706. 16 interactions.
MINTiMINT-393563.
STRINGi4932.YAR003W.

Structurei

3D structure databases

ProteinModelPortaliP39706.
SMRiP39706. Positions 31-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 6340WD 1Add
BLAST
Repeati70 – 10940WD 2Add
BLAST
Repeati212 – 25140WD 3Add
BLAST
Repeati264 – 30744WD 4Add
BLAST
Repeati310 – 35041WD 5Add
BLAST

Sequence similaritiesi

Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00530000064100.
HOGENOMiHOG000204856.
InParanoidiP39706.
KOiK14961.
OMAiLTHTIEN.
OrthoDBiEOG7TXKRS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39706-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNILLQDPFA VLKEHPEKLT HTIENPLRTE CLQFSPCGDY LALGCANGAL
60 70 80 90 100
VIYDMDTFRP ICVPGNMLGA HVRPITSIAW SPDGRLLLTS SRDWSIKLWD
110 120 130 140 150
LSKPSKPLKE IRFDSPIWGC QWLDAKRRLC VATIFEESDA YVIDFSNDPV
160 170 180 190 200
ASLLSKSDEK QLSSTPDHGY VLVCTVHTKH PNIIIVGTSK GWLDFYKFHS
210 220 230 240 250
LYQTECIHSL KITSSNIKHL IVSQNGERLA INCSDRTIRQ YEISIDDENS
260 270 280 290 300
AVELTLEHKY QDVINKLQWN CILFSNNTAE YLVASTHGSS AHELYIWETT
310 320 330 340 350
SGTLVRVLEG AEEELIDINW DFYSMSIVSN GFESGNVYVW SVVIPPKWSA
360 370 380 390 400
LAPDFEEVEE NVDYLEKEDE FDEVDEAEQQ QGLEQEEEIA IDLRTREQYD
410 420
VRGNNLLVER FTIPTDYTRI IKMQSS
Length:426
Mass (Da):48,655
Last modified:February 1, 1995 - v1
Checksum:i90C389612AB66231
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22015 Genomic DNA. Translation: AAC04959.1.
BK006935 Genomic DNA. Translation: DAA06988.1.
PIRiS40901.
RefSeqiNP_009403.1. NM_001178210.1.

Genome annotation databases

EnsemblFungiiYAR003W; YAR003W; YAR003W.
GeneIDi851265.
KEGGisce:YAR003W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22015 Genomic DNA. Translation: AAC04959.1 .
BK006935 Genomic DNA. Translation: DAA06988.1 .
PIRi S40901.
RefSeqi NP_009403.1. NM_001178210.1.

3D structure databases

ProteinModelPortali P39706.
SMRi P39706. Positions 31-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31792. 247 interactions.
DIPi DIP-1753N.
IntActi P39706. 16 interactions.
MINTi MINT-393563.
STRINGi 4932.YAR003W.

Proteomic databases

MaxQBi P39706.
PaxDbi P39706.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAR003W ; YAR003W ; YAR003W .
GeneIDi 851265.
KEGGi sce:YAR003W.

Organism-specific databases

CYGDi YAR003w.
SGDi S000000064. SWD1.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00530000064100.
HOGENOMi HOG000204856.
InParanoidi P39706.
KOi K14961.
OMAi LTHTIEN.
OrthoDBi EOG7TXKRS.

Enzyme and pathway databases

BioCyci YEAST:G3O-28868-MONOMER.

Miscellaneous databases

NextBioi 968231.
PROi P39706.

Gene expression databases

Genevestigatori P39706.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
    Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
    Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4."
    Roguev A., Schaft D., Shevchenko A., Pijnappel W.W.M.P., Wilm M., Aasland R., Stewart A.F.
    EMBO J. 20:7137-7148(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  5. "COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression."
    Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J., Johnston M., Shilatifard A.
    J. Biol. Chem. 277:10753-10755(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: SUBUNIT.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Localization of proteins that are coordinately expressed with Cln2 during the cell cycle."
    Sundin B.A., Chiu C.-H., Riffle M., Davis T.N., Muller E.G.D.
    Yeast 21:793-800(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSWD1_YEAST
AccessioniPrimary (citable) accession number: P39706
Secondary accession number(s): D6VPL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3