P39704 (ERP2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein ERP2

Gene names

Name:	ERP2
Ordered Locus Names:	YAL007C
ORF Names:	FUN54

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in vesicular protein trafficking.
Subunit structure	Associates with EMP24, ERV25 and ERP1.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.
Miscellaneous	Present with 26300 molecules/cell in log phase SD medium. Ref.6
Sequence similarities	Belongs to the EMP24/GP25L family. Contains 1 GOLD domain.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ER to Golgi vesicle-mediated transport Inferred from physical interaction. Source: SGD protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ER to Golgi transport vesicle Inferred from direct assay. Source: SGD endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ERP1	Q05359	7	EBI-6587,EBI-6581
ERV25	P54837	4	EBI-6587,EBI-6642

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 215	190	Protein ERP2		PRO_0000010409
Regions
	Topological domain	26 – 182	157	Lumenal Potential
	Transmembrane	183 – 203	21	Helical; Potential
	Topological domain	204 – 215	12	Cytoplasmic Potential
	Domain	41 – 123	83	GOLD

Sequences

	Sequence		Length	Mass (Da)
	P39704 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 82560055D590954F	FASTA	215	24,064
	10 20 30 40 50 60 MIKSTIALPS FFIVLILALV NSVAASSSYA PVAISLPAFS KECLYYDMVT EDDSLAVGYQ 70 80 90 100 110 120 VLTGGNFEID FDITAPDGSV ITSEKQKKYS DFLLKSFGVG KYTFCFSNNY GTALKKVEIT 130 140 150 160 170 180 LEKEKTLTDE HEADVNNDDI IANNAVEEID RNLNKITKTL NYLRAREWRN MSTVNSTESR 190 200 210 LTWLSILIII IIAVISIAQV LLIQFLFTGR QKNYV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region." Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H. Yeast 10:535-541(1994) [PubMed: 7941740] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed: 7731988] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex." Marzioch M., Henthorn D.C., Herrmann J.M., Wilson R., Thomas D.Y., Bergeron J.J.M., Solari R.C., Rowley A. Mol. Biol. Cell 10:1923-1938(1999) [PubMed: 10359606] [Abstract] Cited for: CHARACTERIZATION.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22015 Genomic DNA. Translation: AAC04951.1. AY558166 Genomic DNA. Translation: AAS56492.1. BK006935 Genomic DNA. Translation: DAA06981.1.
PIR	S43448.
RefSeq	NP_009395.1. NM_001178152.1.
3D structure databases
ProteinModelPortal	P39704.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5808N.
IntAct	P39704. 45 interactions.
MINT	MINT-617311.
STRING	P39704.
Proteomic databases
PeptideAtlas	P39704.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YAL007C; YAL007C; YAL007C.
GeneID	851226.
KEGG	sce:YAL007C.
NMPDR	fig|4932.3.peg.79.
Organism-specific databases
CYGD	YAL007c.
SGD	S000000005. ERP2.
Phylogenomic databases
eggNOG	fuNOG06898.
GeneTree	EFGT00070000008744.
HOGENOM	HBG334070.
OMA	REWRNMS.
OrthoDB	EOG4BVW46.
Gene expression databases
ArrayExpress	P39704.
Genevestigator	P39704.
GermOnline	YAL007C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR009038. GOLD. [Graphical view]
KO	K14825.
Pfam	PF01105. EMP24_GP25L. 1 hit. [Graphical view]
SUPFAM	SSF101576. GOLD. 1 hit.
PROSITE	PS50866. GOLD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	968133.

Entry information

Entry name

ERP2_YEAST

Accession

Primary (citable) accession number: P39704
Secondary accession number(s): D6VPL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program