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P39704 (ERP2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ERP2
Gene names
Name:ERP2
Ordered Locus Names:YAL007C
ORF Names:FUN54
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in vesicular protein trafficking.

Subunit structure

Associates with EMP24, ERV25 and ERP1.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.

Miscellaneous

Present with 26300 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the EMP24/GP25L family.

Contains 1 GOLD domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EMP24P328034EBI-6587,EBI-6431

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 215190Protein ERP2
PRO_0000010409

Regions

Topological domain26 – 182157Lumenal Potential
Transmembrane183 – 20321Helical; Potential
Topological domain204 – 21512Cytoplasmic Potential
Domain41 – 12383GOLD

Sequences

Sequence LengthMass (Da)Tools
P39704 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 82560055D590954F

FASTA21524,064
        10         20         30         40         50         60 
MIKSTIALPS FFIVLILALV NSVAASSSYA PVAISLPAFS KECLYYDMVT EDDSLAVGYQ 

        70         80         90        100        110        120 
VLTGGNFEID FDITAPDGSV ITSEKQKKYS DFLLKSFGVG KYTFCFSNNY GTALKKVEIT 

       130        140        150        160        170        180 
LEKEKTLTDE HEADVNNDDI IANNAVEEID RNLNKITKTL NYLRAREWRN MSTVNSTESR 

       190        200        210 
LTWLSILIII IIAVISIAQV LLIQFLFTGR QKNYV 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex."
Marzioch M., Henthorn D.C., Herrmann J.M., Wilson R., Thomas D.Y., Bergeron J.J.M., Solari R.C., Rowley A.
Mol. Biol. Cell 10:1923-1938(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22015 Genomic DNA. Translation: AAC04951.1.
AY558166 Genomic DNA. Translation: AAS56492.1.
BK006935 Genomic DNA. Translation: DAA06981.1.
PIRS43448.
RefSeqNP_009395.1. NM_001178152.1.

3D structure databases

ProteinModelPortalP39704.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31759. 78 interactions.
DIPDIP-5808N.
IntActP39704. 25 interactions.
MINTMINT-617311.
STRING4932.YAL007C.

Proteomic databases

PaxDbP39704.
PeptideAtlasP39704.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL007C; YAL007C; YAL007C.
GeneID851226.
KEGGsce:YAL007C.

Organism-specific databases

CYGDYAL007c.
SGDS000000005. ERP2.

Phylogenomic databases

eggNOGNOG284261.
GeneTreeENSGT00670000098921.
HOGENOMHOG000000781.
KOK14825.
OMAREWRNMS.
OrthoDBEOG7X0VV7.

Enzyme and pathway databases

BioCycYEAST:G3O-28820-MONOMER.

Gene expression databases

GenevestigatorP39704.

Family and domain databases

InterProIPR009038. GOLD.
[Graphical view]
PfamPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
SUPFAMSSF101576. SSF101576. 1 hit.
PROSITEPS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968133.

Entry information

Entry nameERP2_YEAST
AccessionPrimary (citable) accession number: P39704
Secondary accession number(s): D6VPL1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families