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P39696 (COMER_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ComE operon protein 4
Gene names
Name:comER
Synonyms:comE4, comED
Ordered Locus Names:BSU25600
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase. Ref.4

Sequence similarities

Belongs to the pyrroline-5-carboxylate reductase family.

Sequence caution

The sequence AAC36904.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273ComE operon protein 4
PRO_0000187330

Experimental info

Sequence conflict153 – 1542HP → QA in AAC36904. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P39696 [UniParc].

Last modified October 24, 2003. Version 3.
Checksum: 9E72F798B4EB3F60

FASTA27330,239
        10         20         30         40         50         60 
MKIGFIGTGN MGTILIESFI ESKAADPSNM TITNRTIEKA LHIKNRYNSI NVTESLEKLV 

        70         80         90        100        110        120 
SENEMIFICV KPLDIYPLLA RALPYLRKDH ILISITSPVQ TEQLEQYVPC QVARVIPSIT 

       130        140        150        160        170        180 
NRALAGVSLV TFGTSCGESA KAKINELMQH ISHPLQIESD ITRVASDIVS CGPAFMSYLI 

       190        200        210        220        230        240 
QRFIDAAVSE TSVSKQDAIL MCKEMLVGMG KLLETELYTL PALQEKVCVK GGVTGEGIKA 

       250        260        270 
LESGVQDMFH RVFQNTHMKY EEDISAVKKQ FHV

« Hide

References

« Hide 'large scale' references
[1]"Characterization of comE, a late competence operon of Bacillus subtilis required for the binding and uptake of transforming DNA."
Hahn J., Inamine G., Kozlov Y., Dubnau D.A.
Mol. Microbiol. 10:99-110(1993) [PubMed: 7968523] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
Microbiology 142:3103-3111(1996) [PubMed: 8969508] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / JH642.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[4]"Multiple genes for the last step of proline biosynthesis in Bacillus subtilis."
Belitsky B.R., Brill J., Bremer E., Sonenshein A.L.
J. Bacteriol. 183:4389-4392(2001) [PubMed: 11418582] [Abstract]
Cited for: POSSIBLE FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L15202 Unassigned DNA. Translation: AAC36904.1. Different initiation.
D84432 Genomic DNA. Translation: BAA12451.1.
AL009126 Genomic DNA. Translation: CAB14502.1.
PIRF69602.
RefSeqNP_390438.1. NC_000964.3.

3D structure databases

ProteinModelPortalP39696.
SMRP39696. Positions 1-264.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000000389; EBBACP00000000389; EBBACG00000000387.
GeneID937834.
GenomeReviewsGene locus BSU25600 in contig AL009126_GR.
KEGGbsu:BSU25600.
NMPDRfig|224308.1.peg.2563.
PATRIC18976962. VBIBacSub10457_2670.

Organism-specific databases

GenoListBSU25600. [Micado]

Phylogenomic databases

GeneTreeEBGT00070000032098.
HOGENOMHBG314144.
OMACVKPLDI.
PhylomeDBP39696.
ProtClustDBPRK07680.

Enzyme and pathway databases

BioCycBSUB:BSU25600-MONOMER.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR004455. NADP_OxRdtase_F420.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK02239.
PANTHERPTHR11645. P5CR. 1 hit.
PfamPF03807. F420_oxidored. 1 hit.
[Graphical view]
PIRSFPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00521. P5CR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOMER_BACSU
AccessionPrimary (citable) accession number: P39696
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 24, 2003
Last modified: January 25, 2012
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

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