Reviewed, UniProtKB/Swiss-Prot P39696 (COMER_BACSU)

Names and origin

Protein names

Recommended name:
    ComE operon protein 4

Gene names

Name:	comER
Synonyms:	comE4, comED
Ordered Locus Names:	BSU25600

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase. Ref.4
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	ComE operon protein 4		PRO_0000187330
Experimental info
	Sequence conflict	153 – 154	2	HP → QA in AAC36904. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P39696-1 [UniParc]. Last modified October 24, 2003. Version 3. Checksum: 9E72F798B4EB3F60	FASTA	273	30,239
	10 20 30 40 50 60 MKIGFIGTGN MGTILIESFI ESKAADPSNM TITNRTIEKA LHIKNRYNSI NVTESLEKLV 70 80 90 100 110 120 SENEMIFICV KPLDIYPLLA RALPYLRKDH ILISITSPVQ TEQLEQYVPC QVARVIPSIT 130 140 150 160 170 180 NRALAGVSLV TFGTSCGESA KAKINELMQH ISHPLQIESD ITRVASDIVS CGPAFMSYLI 190 200 210 220 230 240 QRFIDAAVSE TSVSKQDAIL MCKEMLVGMG KLLETELYTL PALQEKVCVK GGVTGEGIKA 250 260 270 LESGVQDMFH RVFQNTHMKY EEDISAVKKQ FHV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of comE, a late competence operon of Bacillus subtilis required for the binding and uptake of transforming DNA." Hahn J., Inamine G., Kozlov Y., Dubnau D.A. Mol. Microbiol. 10:99-110(1993) [PubMed: 7968523] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes." Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y. Microbiology 142:3103-3111(1996) [PubMed: 8969508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168 / JH642.
[3]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[4]	"Multiple genes for the last step of proline biosynthesis in Bacillus subtilis." Belitsky B.R., Brill J., Bremer E., Sonenshein A.L. J. Bacteriol. 183:4389-4392(2001) [PubMed: 11418582] [Abstract] Cited for: POSSIBLE FUNCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L15202 Unassigned DNA. Translation: AAC36904.1. Different initiation. D84432 Genomic DNA. Translation: BAA12451.1. AL009126 Genomic DNA. Translation: CAB14502.1.
PIR	F69602.
RefSeq	NP_390438.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	937834.
GenomeReviews	Gene locus BSU25600 in contig AL009126_GR.
KEGG	bsu:BSU25600.
NMPDR	fig|224308.1.peg.2563.
Organism-specific databases
SubtiList	BG10479. comER. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	P39696.
OMA	P39696. CVKPLDI.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU2556-MON.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COMER_BACSU

Accession

Primary (citable) accession number: P39696

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	October 24, 2003
Last modified:	June 16, 2009
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)