P39691 (DSBC_DICD3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiol:disulfide interchange protein DsbC

Gene names

Name:	dsbC
Ordered Locus Names:	Dda3937_02295

Organism

Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) [Complete proteome] [HAMAP]

Taxonomic identifier

198628 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Dickeya

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase.
Subunit structure	Homodimer.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the thioredoxin family. DsbC subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	By similarity
	Chain	22 – 238	217	Thiol:disulfide interchange protein DsbC		PRO_0000034275
Regions
	Domain	61 – 232	172	Thioredoxin
Amino acid modifications
	Disulfide bond	119 ↔ 122		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	P39691 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 821012F0FC384A16	FASTA	238	25,907
	10 20 30 40 50 60 MKKRVVLFSL LTLALSGVAR ADDAAIKQTL NRLGLQSAEV KDSPIGGMKT VLTENGVLYI 70 80 90 100 110 120 TEDGKHLLQG PLYDVSGKTP VNVTNHILNE RLDALKDQMI VYKAPQEKHV ITVFTDITCG 130 140 150 160 170 180 YCHKLHEQMK DYNALGITVR YLAYPRQGMN SQAAKDMQSI WCVADRNKAF DAAMKGDDVS 190 200 210 220 230 PATCKTDIGA HYQLGVLFGV QGTPAIVLDD GTVVPGYQPP KEMMAMLDAH KASLKSGG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of DsbC, a periplasmic protein of Erwinia chrysanthemi and Escherichia coli with disulfide isomerase activity." Shevchik V.E., Condemine G., Robert-Baudouy J. EMBO J. 13:2007-2012(1994) [PubMed: 8168497] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 3937.
[2]	"Complete genome sequence of Dickeya dadantii 3937." International Erwinia Consortium Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 3937.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X76687 Genomic DNA. Translation: CAA54108.1. CP002038 Genomic DNA. Translation: ADM96890.1.
PIR	S44444.
RefSeq	YP_003881447.1. NC_014500.1.
3D structure databases
ProteinModelPortal	P39691.
SMR	P39691. Positions 22-231.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9732089.
GenomeReviews	Gene locus Dda3937_02295 in contig CP002038_GR.
KEGG	ddd:Dda3937_02295.
PATRIC	42313721. VBIDicDad25310_0693.
Organism-specific databases
CMR	Search...
Family and domain databases
InterPro	IPR018950. DiS-bond_isomerase_DsbC/G_N. IPR009094. DiS-bond_isomerase_DsbC_N. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.10.450.70. Disulf_isomers_N. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K03981.
Pfam	PF10411. DsbC_N. 1 hit. [Graphical view]
SUPFAM	SSF54423. Disulfide_bond_isomerase_N. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBC_DICD3

Accession

Primary (citable) accession number: P39691
Secondary accession number(s): E0SLQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program