Reviewed, UniProtKB/Swiss-Prot P39691 (DSBC_DICD3)

Names and origin

Protein names

Recommended name:
    Thiol:disulfide interchange protein dsbC

Gene names

Name:

dsbC

Organism

Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))

Taxonomic identifier

198628 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Dickeya

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase.
Subunit structure	Homodimer.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the thioredoxin family. DsbC subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	By similarity
	Chain	22 – 238	217	Thiol:disulfide interchange protein dsbC		PRO_0000034275
Regions
	Domain	61 – 232	172	Thioredoxin
Amino acid modifications
	Disulfide bond	119 ↔ 122		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	P39691-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 821012F0FC384A16	FASTA	238	25,907
	10 20 30 40 50 60 MKKRVVLFSL LTLALSGVAR ADDAAIKQTL NRLGLQSAEV KDSPIGGMKT VLTENGVLYI 70 80 90 100 110 120 TEDGKHLLQG PLYDVSGKTP VNVTNHILNE RLDALKDQMI VYKAPQEKHV ITVFTDITCG 130 140 150 160 170 180 YCHKLHEQMK DYNALGITVR YLAYPRQGMN SQAAKDMQSI WCVADRNKAF DAAMKGDDVS 190 200 210 220 230 PATCKTDIGA HYQLGVLFGV QGTPAIVLDD GTVVPGYQPP KEMMAMLDAH KASLKSGG

References

[1]	"Characterization of DsbC, a periplasmic protein of Erwinia chrysanthemi and Escherichia coli with disulfide isomerase activity." Shevchik V.E., Condemine G., Robert-Baudouy J. EMBO J. 13:2007-2012(1994) [PubMed: 8168497] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X76687 Genomic DNA. Translation: CAA54108.1.
PIR	S44444.
3D structure databases
HSSP	HSSP built from PDB template 1JZD based on UniProtKB P21892.
ModBase	Search...
Family and domain databases
InterPro	IPR018950. dS-bond_isomerase_DsbC/G_N. IPR009094. dS-bond_isomerase_DsbC_N. IPR017936. Thioredoxin-like. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.10.450.70. Disulf_isomers_N. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF10411. DsbC_N. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBC_DICD3

Accession

Primary (citable) accession number: P39691

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)