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Reviewed, UniProtKB/Swiss-Prot P39689 (CDN1A_MOUSE)

Last modified December 15, 2009. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cyclin-dependent kinase inhibitor 1
Alternative name(s):
    p21
    CDK-interacting protein 1
    Melanoma differentiation-associated protein
Gene names
Name: Cdkn1a
Synonyms: Cip1, Waf1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.

Subunit structure

Interacts with MKRN1 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Induction

By p53, mezerein (antileukemic compound) and interferon beta.

Post-translational modification

Phosphorylation of Thr-140 or Ser-141 impairs binding to PCNA By similarity.

Ubiquitinated by MKRN1; leading to polyubiquitination and 26S proteasome-dependent degradation By similarity.

Sequence similarities

Belongs to the CDI family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Gadd45gQ9Z1111EBI-1174103,EBI-1173616

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 159158Cyclin-dependent kinase inhibitor 1
PRO_0000190080

Regions

Zinc finger12 – 4029C4-type Potential

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue1251Phosphoserine By similarity
Modified residue1401Phosphothreonine By similarity
Modified residue1411Phosphoserine By similarity

Experimental info

Sequence conflict301R → S Ref.4
Sequence conflict56 – 572TP → RQ Ref.4

Sequences

Sequence LengthMass (Da)Tools
P39689-1 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 37B7C22B9A2FD089

FASTA15917,785
        10         20         30         40         50         60 
MSNPGDVRPV PHRSKVCRCL FGPVDSEQLR RDCDALMAGC LQEARERWNF DFVTETPLEG 

        70         80         90        100        110        120 
NFVWERVRSL GLPKVYLSPG SRSRDDLGGD KRPSTSSALL QGPAPEDHVA LSLSCTLVSE 

       130        140        150 
RPEDSPGGPG TSQGRKRRQT SLTDFYHSKR RLVFCKRKP 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1)."
Huppi K., Siwarski D., Dosik J., Michieli P., Chedid M., Reed S., Mock B., Givol D., Mushinski J.F.
Oncogene 9:3017-3020(1994) [PubMed: 8084607] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BXSB.
Tissue: Spleen.
[2]"Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues."
El-Deiry W.S., Tokino T., Waldman T., Velculescu V.E., Oliner J.D., Burell M., Hill D.E., Rees J.L., Hamilton S.R., Kinzler K.W., Vogelstein B.
Cancer Res. 55:2910-2919(1995) [PubMed: 7796420] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[4]"WAF1, a potential mediator of p53 tumor suppression."
El-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., Vogelstein B.
Cell 75:817-825(1993) [PubMed: 8242752] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-143.
+Additional computationally mapped references.

Cross-references

Sequence databases

U09507 mRNA. Translation: AAB60456.1.
U24173 mRNA. Translation: AAC52220.1.
BC002043 mRNA. Translation: AAH02043.1.
IPIIPI00108058.
PIRA49438.
I49023.
RefSeqNP_001104569.1.
NP_031695.1.
UniGeneMm.195663

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP-24178N.
IntActP39689. 2 interactions.
STRINGP39689.

PTM databases

PhosphoSiteP39689.

Proteomic databases

PRIDEP39689.

Genome annotation databases

EnsemblENSMUST00000023829; ENSMUSP00000023829; ENSMUSG00000023067; Mus musculus. [Genome view]
ENSMUST00000119901; ENSMUSP00000113150; ENSMUSG00000023067; Mus musculus. [Genome view]
ENSMUST00000122348; ENSMUSP00000112411; ENSMUSG00000023067; Mus musculus. [Genome view]
GeneID12575.
KEGGmmu:12575.
UCSCuc008bsg.1. mouse.

Organism-specific databases

CTD12575.
MGIMGI:104556. Cdkn1a.

Phylogenomic databases

HOGENOMHBG506854.
HOVERGENP39689.
InParanoidP39689.
OMARRDCDAL.
OrthoDBEOG9WM7DW.

Gene expression databases

ArrayExpressP39689.
BgeeP39689.
CleanExMM_CDKN1A.
GenevestigatorP39689.
GermOnlineENSMUSG00000023067. Mus musculus.

Family and domain databases

InterProIPR003175. CDI.
[Graphical view]
PANTHERPTHR10265. CDI. 1 hit.
PfamPF02234. CDI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio281686.
SOURCESearch...

Entry information

Entry nameCDN1A_MOUSE
AccessionPrimary (citable) accession number: P39689
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: December 15, 2009
This is version 84 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents