P39684 (PES4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein PES4

Alternative name(s):
DNA polymerase epsilon suppressor 4

Gene names

Name:	PES4
Ordered Locus Names:	YFR023W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	611 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus Potential.
Sequence similarities	Contains 4 RRM (RNA recognition motif) domains.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 611	611	Protein PES4		PRO_0000081724
Regions
	Domain	91 – 169	79	RRM 1
	Domain	179 – 247	69	RRM 2
	Domain	303 – 379	77	RRM 3
	Domain	393 – 471	79	RRM 4
	Compositional bias	54 – 64	11	Poly-Ser
Experimental info
	Sequence conflict	124	1	L → I in BAA05461. Ref.1
	Sequence conflict	541 – 611	71	QVRRG…LGFKR → ASKKRYRFHEISKCH in BAA05461. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P39684 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 78519E76A8058701	FASTA	611	70,842
	10 20 30 40 50 60 MYSISNKKPS ILSMVPLNIL KNQDLKVKKD QEKKISFNPV VTPIRPDDYH EKTSRSSSSS 70 80 90 100 110 120 HSDSPEFLRI NNNKSGHKNG KLKSFESKKL VPLFIGDLHE TVTEETLKGI FKKYPSFVSA 130 140 150 160 170 180 KVCLDSVTKK SLGHGYLNFE DKEEAEKAME ELNYTKVNGK EIRIMPSLRN TTFRKNFGTN 190 200 210 220 230 240 VFFSNLPLNN PLLTTRVFYD TFSRYGKILS CKLDSRKDIG FVYFEDEKTA RNVIKMYNNT 250 260 270 280 290 300 SFFGKKILCG IHFDKEVRSV PNFETQKSRL DAETIIEKEQ SLNEKHSKGN DKESKNIYSS 310 320 330 340 350 360 SQNSIFIKNL PTITTRDDIL NFFSEVGPIK SIYLSNATKV KYLWAFVTYK NSSDSEKAIK 370 380 390 400 410 420 RYNNFYFRGK KLLVTRAQDK EERAKFIESQ KISTLFLENL SAVCNKEFLK YLCHQENIRP 430 440 450 460 470 480 FKIQIDGYDE NSSTYSGFIK FRNFEDATRI FNFLNNRLVG GSIVTTSWER QNNAPKYHDG 490 500 510 520 530 540 YGMRNIHTSS HPQITPYYQY SHANSLNSPH MRDLSSMNSS TRSLIKNKNF NKKVLETFEK 550 560 570 580 590 600 QVRRGIDFMR FPSATRDENV HGIAEYIFDT YWNRDVLILD KFLSLLNSSP YHEGVLQKQI 610 EEAASSLGFK R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Araki H. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SK1.
[2]	"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed: 7670463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D26442 Genomic DNA. Translation: BAA05461.1. D50617 Genomic DNA. Translation: BAA09262.1. BK006940 Genomic DNA. Translation: DAA12463.1.
PIR	S56278.
RefSeq	NP_116678.1. NM_001179988.1.
3D structure databases
ProteinModelPortal	P39684.
SMR	P39684. Positions 86-169, 176-252, 300-479.
ModBase	Search...
Protein-protein interaction databases
STRING	P39684.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YFR023W; YFR023W; YFR023W.
GeneID	850579.
KEGG	sce:YFR023W.
NMPDR	fig|4932.3.peg.2312.
Organism-specific databases
CYGD	YFR023w.
SGD	S000001919. PES4.
Phylogenomic databases
eggNOG	fuNOG04633.
GeneTree	EFGT00050000000240.
HOGENOM	HBG203847.
OMA	ILSCKLD.
OrthoDB	EOG45HW68.
Gene expression databases
ArrayExpress	P39684.
Genevestigator	P39684.
GermOnline	YFR023W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 4 hits.
Pfam	PF00076. RRM_1. 3 hits. [Graphical view]
SMART	SM00360. RRM. 4 hits. [Graphical view]
PROSITE	PS50102. RRM. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	966406.

Entry information

Entry name

PES4_YEAST

Accession

Primary (citable) accession number: P39684
Secondary accession number(s): D6VTQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 1, 1995
Last modified:	December 14, 2011
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program