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Protein

Mite allergen Der p 3

Gene

DERP3

Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691Charge relay systemBy similarity
Active sitei114 – 1141Charge relay systemBy similarity
Sitei208 – 2081Required for specificity
Active sitei214 – 2141Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

SABIO-RKP39675.

Protein family/group databases

MEROPSiS01.031.

Names & Taxonomyi

Protein namesi
Recommended name:
Mite allergen Der p 3 (EC:3.4.21.-)
Alternative name(s):
Allergen Der p III
Allergen: Der p 3
Gene namesi
Name:DERP3
OrganismiDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifieri6956 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei317. Der p 3.
3263. Der p 3.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 29112 PublicationsPRO_0000028145Add
BLAST
Chaini30 – 261232Mite allergen Der p 3PRO_0000028146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 70PROSITE-ProRule annotation
Disulfide bondi181 ↔ 198PROSITE-ProRule annotation
Disulfide bondi210 ↔ 236PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP39675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 260231Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYNILIVL LLAINTLANP ILPASPNATI VGGEKALAGE CPYQISLQSS
60 70 80 90 100
SHFCGGTILD EYWILTAAHC VAGQTASKLS IRYNSLKHSL GGEKISVAKI
110 120 130 140 150
FAHEKYDSYQ IDNDIALIKL KSPMKLNQKN AKAVGLPAKG SDVKVGDQVR
160 170 180 190 200
VSGWGYLEEG SYSLPSELRR VDIAVVSRKE CNELYSKANA EVTDNMICGG
210 220 230 240 250
DVANGGKDSC QGDSGGPVVD VKNNQVVGIV SWGYGCARKG YPGVYTRVGN
260
FIDWIESKRS Q
Length:261
Mass (Da):28,060
Last modified:February 1, 1995 - v1
Checksum:i066C7C25E0D67FBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11719 mRNA. Translation: AAA19973.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11719 mRNA. Translation: AAA19973.1.

3D structure databases

ProteinModelPortaliP39675.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei317. Der p 3.
3263. Der p 3.0101.
MEROPSiS01.031.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP39675.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of the Dermatophagoides pteronyssinus group III allergen, Der p III."
    Smith W.-A., Chua K.-Y., Kuo M.C., Rogers B.L., Thomas W.R.
    Clin. Exp. Allergy 24:220-228(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-59.
  2. "The group III allergen from the house dust mite Dermatophagoides pteronyssinus is a trypsin-like enzyme."
    Stewart G.A., Ward L.D., Simpson R.J., Thompson P.J.
    Immunology 75:29-35(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-47 AND 223-229.

Entry informationi

Entry nameiDERP3_DERPT
AccessioniPrimary (citable) accession number: P39675
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 16, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.