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P39653

- DEXT_STRDO

UniProt

P39653 - DEXT_STRDO

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Protein

Dextranase

Gene

dex

Organism
Streptococcus downei (Streptococcus sobrinus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in sucrose-independent adherence to the pellicle-coated tooth surface.

Catalytic activityi

Endohydrolysis of (1->6)-alpha-D-glucosidic linkages in dextran.

pH dependencei

Optimum pH is 5.3.

Temperature dependencei

Optimum temperature is 39 degrees Celsius.

GO - Molecular functioni

  1. dextranase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.11. 5954.

Protein family/group databases

CAZyiGH66. Glycoside Hydrolase Family 66.

Names & Taxonomyi

Protein namesi
Recommended name:
Dextranase (EC:3.2.1.11)
Alternative name(s):
Alpha-1,6-glucan-6-glucanohydrolase
Gene namesi
Name:dex
Encoded oniPlasmid pYA9020 Publication
OrganismiStreptococcus downei (Streptococcus sobrinus)
Taxonomic identifieri1317 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  1. cell wall Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 PublicationAdd
BLAST
Chaini31 – 13081278DextranasePRO_0000012236Add
BLAST
Propeptidei1309 – 133729Removed by sortasePROSITE-ProRule annotationPRO_0000012237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1308 – 13081Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Subunit structurei

Homodimer.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1305 – 13095LPXTG sorting signal

Sequence similaritiesi

Belongs to the glycosyl hydrolase 66 family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiIPR025092. Glyco_hydro_66.
IPR019931. LPXTG_anchor.
[Graphical view]
PfamiPF13199. Glyco_hydro_66. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39653-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNRMLSFPS MLFLLAFGIV LSVSAGTTHA DELANQTAKV ADEASIVVST
60 70 80 90 100
SQAAVEQTQS QEKEISPAME EDTSNLSLKP NAQQESQSPD SSTELQDPAE
110 120 130 140 150
QTPPETSDAS APATTSADSV EKYAQDATQN QSSTSNGPGV IRATSAQVTA
160 170 180 190 200
TRSVVSSQSG DAIVDLSADK ASYRQGEDVN LSVDFKNTTD KEQDVTVYAD
210 220 230 240 250
VYYIDNKLGT YKFSKHLKAG EGYKMQSGDL KIPASQFENN HGYLLKVRVR
260 270 280 290 300
DADNNTLSEV NKAIAVESDW TKFPRYGIVG GSQDTNNSLL SKDADRYRAE
310 320 330 340 350
IEKMKNMNIN SYFFYDVYKT ATNPFPSDEA TFKQDWNTWS GSEIDTQAVK
360 370 380 390 400
DIVNQVHDGG AVAMLYNMIL AENTNTGEAP VLPETEYAYN SDDRGYGAQG
410 420 430 440 450
QPMSYTVKIP KDGQEEDVEI QRYYNPTSKL WQDYIADKMG QAMKNGGFDG
460 470 480 490 500
WQGDTIGDNE VYSYADKDSN DPSKKFWLTE GYAEFLRAIK EKLPNYYLTV
510 520 530 540 550
NDVNGEQIYR LKDGNQDVIY NEIWPFGPAL PSEMAAVKPN TVTSRPVLTK
560 570 580 590 600
VRQGDWKISI VGAYMEGSEN GGSKADAEAG KSLQTDAVLL TSASIAAAGG
610 620 630 640 650
YHMSLAALAN QQDETDGGQG IGVLQTAYYP TQSLKTSSEL TRKNNDYQQF
660 670 680 690 700
ITAYENVLRD GVENDDAQVN TFDSNGQKLS TDAKGITGNQ VWTYGKKGDN
710 720 730 740 750
FRTVQLLNLM GINSDWKNED GSAANKTPDE QTNLTVKYAL GDVSMEDAQR
760 770 780 790 800
MANQTYVTSP DDWSKSNLQK VSASVKTDEN GKPVLVINVP KLTLWDVVYI
810 820 830 840 850
SNANQESAPE ADQAQTPAAQ SSDDKVAENE TSQPAAEDAK EQTSEPAQDQ
860 870 880 890 900
AAPAEQGQAI NQAESPATEP EAEVTPATAE PAKVDAPEAN QAADQAVSPE
910 920 930 940 950
PASQEQAASQ SQPEANQTPA SNETPATQGN SEQPELNEPT AQTQPSSQVS
960 970 980 990 1000
PANTSVTPVA EQPTNQGQAA DKADQAPTNS TSTPESTSPV EPAATDQSSD
1010 1020 1030 1040 1050
TPIVTAGNLS VQPAETETPT VPDKQGDSKA NQSSTETPVA DQVPAVAEQP
1060 1070 1080 1090 1100
QATEPNQAKP SVDKAAAPEA LSLIQLKQQT PAIQAKEADD PEVDETKSEV
1110 1120 1130 1140 1150
TPDSGTDKAP EAGQVDSDKA PTVKPSTPEN NDNQPNNAND ADKNKTNEAD
1160 1170 1180 1190 1200
SNKANQDSTK GSSADQSGKS TTPEDGPDNS SPEDPETKPS DPNTDTSDQE
1210 1220 1230 1240 1250
QVKPSLPVVP NQTVDDPKTD DTDTPANTDS AKSKKVADAD KNKVATDSEG
1260 1270 1280 1290 1300
RQKSSEFPKE ATDLEKVGQP ASPQVAGVKS SVATSPEKKS EPVSKTSTTS
1310 1320 1330
SSDKLPKTGD HKTVVLIIVL GLVFVGMTGL LARHEKK
Length:1,337
Mass (Da):143,298
Last modified:February 1, 1995 - v1
Checksum:iB494275A77A2E3D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96978 Genomic DNA. Translation: AAA21772.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96978 Genomic DNA. Translation: AAA21772.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH66. Glycoside Hydrolase Family 66.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 3.2.1.11. 5954.

Family and domain databases

InterProi IPR025092. Glyco_hydro_66.
IPR019931. LPXTG_anchor.
[Graphical view ]
Pfami PF13199. Glyco_hydro_66. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification and characterization of Streptococcus sobrinus dextranase produced in recombinant Escherichia coli and sequence analysis of the dextranase gene."
    Wanda S.-Y., Curtiss R. III
    J. Bacteriol. 176:3839-3850(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 31-36.
    Strain: 6715 / UAB66.

Entry informationi

Entry nameiDEXT_STRDO
AccessioniPrimary (citable) accession number: P39653
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Direct protein sequencing, Plasmid

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3