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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciBSUB:BSU37660-MONOMER.
UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Vegetative protein 43
Short name:
VEG43
Gene namesi
Name:pta
Synonyms:ywfJ
Ordered Locus Names:BSU37660
ORF Names:ipa-88d
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001791202 – 323Phosphate acetyltransferaseAdd BLAST322

Proteomic databases

PaxDbiP39646.
PRIDEiP39646.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100020346.

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 12Combined sources11
Beta strandi18 – 22Combined sources5
Helixi27 – 38Combined sources12
Beta strandi41 – 48Combined sources8
Helixi50 – 58Combined sources9
Turni59 – 61Combined sources3
Beta strandi68 – 70Combined sources3
Turni72 – 74Combined sources3
Helixi78 – 88Combined sources11
Turni89 – 91Combined sources3
Helixi95 – 101Combined sources7
Helixi105 – 114Combined sources10
Beta strandi119 – 123Combined sources5
Helixi129 – 138Combined sources10
Beta strandi150 – 157Combined sources8
Beta strandi160 – 165Combined sources6
Beta strandi167 – 169Combined sources3
Helixi175 – 190Combined sources16
Turni191 – 193Combined sources3
Beta strandi198 – 201Combined sources4
Beta strandi203 – 205Combined sources3
Helixi212 – 227Combined sources16
Beta strandi233 – 237Combined sources5
Helixi239 – 243Combined sources5
Helixi245 – 251Combined sources7
Beta strandi254 – 256Combined sources3
Beta strandi262 – 265Combined sources4
Helixi269 – 281Combined sources13
Turni282 – 284Combined sources3
Beta strandi286 – 297Combined sources12
Beta strandi299 – 301Combined sources3
Helixi308 – 322Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TD9X-ray2.75A/B/C/D/E/F1-323[»]
1XCOX-ray2.85A/B/C/D/E/F1-323[»]
ProteinModelPortaliP39646.
SMRiP39646.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39646.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IJ2. Bacteria.
COG0280. LUCA.
HOGENOMiHOG000053796.
InParanoidiP39646.
KOiK00625.
OMAiGVFIMAR.
PhylomeDBiP39646.

Family and domain databases

InterProiIPR012147. P_Ac_Bu_trans.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLFSTVQE KVAGKDVKIV FPEGLDERIL EAVSKLAGNK VLNPIVIGNE
60 70 80 90 100
NEIQAKAKEL NLTLGGVKIY DPHTYEGMED LVQAFVERRK GKATEEQARK
110 120 130 140 150
ALLDENYFGT MLVYKGLADG LVSGAAHSTA DTVRPALQII KTKEGVKKTS
160 170 180 190 200
GVFIMARGEE QYVFADCAIN IAPDSQDLAE IAIESANTAK MFDIEPRVAM
210 220 230 240 250
LSFSTKGSAK SDETEKVADA VKIAKEKAPE LTLDGEFQFD AAFVPSVAEK
260 270 280 290 300
KAPDSEIKGD ANVFVFPSLE AGNIGYKIAQ RLGNFEAVGP ILQGLNMPVN
310 320
DLSRGCNAED VYNLALITAA QAL
Length:323
Mass (Da):34,791
Last modified:January 23, 2007 - v3
Checksum:i7F4A56981C151AF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73124 Genomic DNA. Translation: CAA51644.1.
AL009126 Genomic DNA. Translation: CAB15793.1.
PIRiS39743.
RefSeqiNP_391646.1. NC_000964.3.
WP_003243393.1. NZ_JNCM01000034.1.

Genome annotation databases

EnsemblBacteriaiCAB15793; CAB15793; BSU37660.
GeneIDi936581.
KEGGibsu:BSU37660.
PATRICi18979570. VBIBacSub10457_3947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73124 Genomic DNA. Translation: CAA51644.1.
AL009126 Genomic DNA. Translation: CAB15793.1.
PIRiS39743.
RefSeqiNP_391646.1. NC_000964.3.
WP_003243393.1. NZ_JNCM01000034.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TD9X-ray2.75A/B/C/D/E/F1-323[»]
1XCOX-ray2.85A/B/C/D/E/F1-323[»]
ProteinModelPortaliP39646.
SMRiP39646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100020346.

Proteomic databases

PaxDbiP39646.
PRIDEiP39646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15793; CAB15793; BSU37660.
GeneIDi936581.
KEGGibsu:BSU37660.
PATRICi18979570. VBIBacSub10457_3947.

Phylogenomic databases

eggNOGiENOG4108IJ2. Bacteria.
COG0280. LUCA.
HOGENOMiHOG000053796.
InParanoidiP39646.
KOiK00625.
OMAiGVFIMAR.
PhylomeDBiP39646.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.
BioCyciBSUB:BSU37660-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP39646.

Family and domain databases

InterProiIPR012147. P_Ac_Bu_trans.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTAS_BACSU
AccessioniPrimary (citable) accession number: P39646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.