P39646 (PTAS_BACSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphate acetyltransferase
EC=2.3.1.8

Alternative name(s):
Phosphotransacetylase
Vegetative protein 43
Short name=VEG43

Gene names

Name:	pta
Synonyms:	ywfJ
Ordered Locus Names:	BSU37660
ORF Names:	ipa-88d

Organism

Bacillus subtilis

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Acetyl-CoA + phosphate = CoA + acetyl phosphate.
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the phosphate acetyltransferase and butyryltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphate acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.3

Chain

2 – 323

322

Phosphate acetyltransferase

PRO_0000179120

Secondary structure

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323

Helix Strand Turn

Details...

Helix

2 – 12

11

Beta strand

18 – 22

5

Helix

27 – 38

12

Beta strand

41 – 48

8

Helix

50 – 58

9

Turn

59 – 61

3

Beta strand

68 – 70

3

Turn

72 – 74

3

Helix

78 – 88

11

Turn

89 – 91

3

Helix

95 – 101

7

Helix

105 – 114

10

Beta strand

119 – 123

5

Helix

129 – 138

10

Beta strand

150 – 157

8

Beta strand

160 – 165

6

Beta strand

167 – 169

3

Helix

175 – 190

16

Turn

191 – 193

3

Beta strand

198 – 201

4

Beta strand

203 – 205

3

Helix

212 – 227

16

Beta strand

233 – 237

5

Helix

239 – 243

5

Helix

245 – 251

7

Beta strand

262 – 265

4

Helix

269 – 281

13

Turn

282 – 284

3

Beta strand

286 – 297

12

Beta strand

299 – 301

3

Helix

308 – 322

15

Sequences

	Sequence		Length	Mass (Da)
	P39646 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 7F4A56981C151AF6	FASTA	323	34,791
	10 20 30 40 50 60 MADLFSTVQE KVAGKDVKIV FPEGLDERIL EAVSKLAGNK VLNPIVIGNE NEIQAKAKEL 70 80 90 100 110 120 NLTLGGVKIY DPHTYEGMED LVQAFVERRK GKATEEQARK ALLDENYFGT MLVYKGLADG 130 140 150 160 170 180 LVSGAAHSTA DTVRPALQII KTKEGVKKTS GVFIMARGEE QYVFADCAIN IAPDSQDLAE 190 200 210 220 230 240 IAIESANTAK MFDIEPRVAM LSFSTKGSAK SDETEKVADA VKIAKEKAPE LTLDGEFQFD 250 260 270 280 290 300 AAFVPSVAEK KAPDSEIKGD ANVFVFPSLE AGNIGYKIAQ RLGNFEAVGP ILQGLNMPVN 310 320 DLSRGCNAED VYNLALITAA QAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bacillus subtilis genome project: cloning and sequencing of the 97 kb region from 325 degrees to 333 degrees." Glaser P., Kunst F., Arnaud M., Coudart M.P., Gonzales W., Hullo M.-F., Ionescu M., Lubochinsky B., Marcelino L., Moszer I., Presecan E., Santana M., Schneider E., Schweizer J., Vertes A., Rapoport G., Danchin A. Mol. Microbiol. 10:371-384(1993) [PubMed: 7934828] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[3]	"First steps from a two-dimensional protein index towards a response-regulation map for Bacillus subtilis." Antelmann H., Bernhardt J., Schmid R., Mach H., Voelker U., Hecker M. Electrophoresis 18:1451-1463(1997) [PubMed: 9298659] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-11. Strain: 168 / IS58.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X73124 Genomic DNA. Translation: CAA51644.1.
AL009126 Genomic DNA. Translation: CAB15793.1.

PIR

S39743.

RefSeq

NP_391646.1. NC_000964.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1TD9	X-ray	2.75	A/B/C/D/E/F	2-322	[»]
1XCO	X-ray	2.85	A/B/C/D/E/F	2-322	[»]

ProteinModelPortal

P39646.

SMR

P39646. Positions 1-323.

ModBase

Search...

PTM databases

PhosSite

P39646.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBBACT00000003865; EBBACP00000003865; EBBACG00000003857.

GeneID

936581.

GenomeReviews

Gene locus BSU37660 in contig AL009126_GR.

KEGG

bsu:BSU37660.

NMPDR

fig|224308.1.peg.3772.

PATRIC

18979570. VBIBacSub10457_3947.

Organism-specific databases

GenoList

BSU37660. [Micado]

Phylogenomic databases

GeneTree

EBGT00070000032020.

HOGENOM

HBG576804.

OMA

LMFADCA.

PhylomeDB

P39646.

ProtClustDB

PRK09653.

Enzyme and pathway databases

BioCyc

BSUB:BSU37660-MONOMER.

Family and domain databases

InterPro

IPR012147. P_Ac_Bu_trans.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]

KO

K00625.

Pfam

PF01515. PTA_PTB. 1 hit.
[Graphical view]

PIRSF

PIRSF000428. P_Ac_trans. 1 hit.

TIGRFAMs

TIGR00651. Pta. 1 hit.

ProtoNet

Search...

Entry information

Entry name

PTAS_BACSU

Accession

Primary (citable) accession number: P39646

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 92 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program