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Protein

Bacilysin biosynthesis protein BacB

Gene

bacB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the bacABCDE operon responsible for the biosynthesis of bacilysin.

Pathwayi: bacilysin biosynthesis

This protein is involved in the pathway bacilysin biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacilysin biosynthesis and in Antibiotic biosynthesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU37730-MONOMER.
UniPathwayiUPA00100.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacilysin biosynthesis protein BacB
Gene namesi
Name:bacB
Synonyms:ywfC
Ordered Locus Names:BSU37730
ORF Names:ipa-81d
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Bacilysin biosynthesis protein BacBPRO_0000064801Add
BLAST

Proteomic databases

PaxDbiP39639.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100020381.

Structurei

Secondary structure

1
235
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 118Combined sources
Beta strandi16 – 194Combined sources
Beta strandi25 – 317Combined sources
Beta strandi34 – 418Combined sources
Beta strandi45 – 506Combined sources
Beta strandi53 – 6917Combined sources
Beta strandi72 – 776Combined sources
Turni78 – 803Combined sources
Beta strandi82 – 854Combined sources
Beta strandi91 – 955Combined sources
Beta strandi97 – 993Combined sources
Beta strandi101 – 1088Combined sources
Beta strandi121 – 1233Combined sources
Beta strandi127 – 1326Combined sources
Beta strandi137 – 1426Combined sources
Beta strandi145 – 1528Combined sources
Turni154 – 1563Combined sources
Beta strandi157 – 1626Combined sources
Beta strandi165 – 1728Combined sources
Beta strandi177 – 1815Combined sources
Beta strandi184 – 1885Combined sources
Beta strandi193 – 1964Combined sources
Beta strandi202 – 2065Combined sources
Beta strandi208 – 2103Combined sources
Beta strandi212 – 2209Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H7JX-ray1.87A/B1-235[»]
3H7YX-ray2.22A/B1-235[»]
3H9AX-ray2.04A/B1-235[»]
ProteinModelPortaliP39639.
SMRiP39639. Positions 2-225.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39639.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4106CHD. Bacteria.
ENOG410ZIZ7. LUCA.
HOGENOMiHOG000009192.
KOiK19547.
OMAiGYDMTIE.
OrthoDBiEOG63JR7G.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR013096. Cupin_2.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF07883. Cupin_2. 2 hits.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

P39639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKEDMQEL YFPTPKLIEW ENGVRQYSTV RGDTEVLMSY VPPHTNVEPH
60 70 80 90 100
QHKEVQIGMV VSGELMMTVG DVTRKMTALE SAYIAPPHVP HGARNDTDQE
110 120 130 140 150
VIAIDIKRLK ADETYTSPED YFLDIFKTRD LLPGMEVTFF VEDWVEIMLA
160 170 180 190 200
KIPGNGGEMP FHKHRNEQIG ICIGGGYDMT VEGCTVEMKF GTAYFCEPRE
210 220 230
DHGAINRSEK ESKSINIFFP PRYNRAKAKK MKADE
Length:235
Mass (Da):26,840
Last modified:February 1, 1995 - v1
Checksum:i9A9A1608148D0FA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73124 Genomic DNA. Translation: CAA51637.1.
AL009126 Genomic DNA. Translation: CAB15800.1.
PIRiS39736.
RefSeqiNP_391653.1. NC_000964.3.
WP_003244300.1. NZ_JNCM01000034.1.

Genome annotation databases

EnsemblBacteriaiCAB15800; CAB15800; BSU37730.
GeneIDi937084.
KEGGibsu:BSU37730.
PATRICi18979584. VBIBacSub10457_3954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73124 Genomic DNA. Translation: CAA51637.1.
AL009126 Genomic DNA. Translation: CAB15800.1.
PIRiS39736.
RefSeqiNP_391653.1. NC_000964.3.
WP_003244300.1. NZ_JNCM01000034.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H7JX-ray1.87A/B1-235[»]
3H7YX-ray2.22A/B1-235[»]
3H9AX-ray2.04A/B1-235[»]
ProteinModelPortaliP39639.
SMRiP39639. Positions 2-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100020381.

Proteomic databases

PaxDbiP39639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15800; CAB15800; BSU37730.
GeneIDi937084.
KEGGibsu:BSU37730.
PATRICi18979584. VBIBacSub10457_3954.

Phylogenomic databases

eggNOGiENOG4106CHD. Bacteria.
ENOG410ZIZ7. LUCA.
HOGENOMiHOG000009192.
KOiK19547.
OMAiGYDMTIE.
OrthoDBiEOG63JR7G.

Enzyme and pathway databases

UniPathwayiUPA00100.
BioCyciBSUB:BSU37730-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP39639.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR013096. Cupin_2.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF07883. Cupin_2. 2 hits.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Guanine nucleotides guanosine 5'-diphosphate 3'-diphosphate and GTP co-operatively regulate the production of an antibiotic bacilysin in Bacillus subtilis."
    Inaoka T., Takahashi K., Ohnishi-Kameyama M., Yoshida M., Ochi K.
    J. Biol. Chem. 278:2169-2176(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION.
    Strain: 168 / 61884.
  4. "bac genes for recombinant bacilysin and anticapsin production in Bacillus host strains."
    Steinborn G., Hajirezaei M.-R., Hofemeister J.
    Arch. Microbiol. 183:71-79(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN BACILYSIN PRODUCTION, GENE NAME.

Entry informationi

Entry nameiBACB_BACSU
AccessioniPrimary (citable) accession number: P39639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 17, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The compound ppGpp is essential for the transcription of the bacABCDE operon and GTP regulates the transcription of both this operon and ywfH via the CodY-mediated regulation system.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.