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Reviewed, UniProtKB/Swiss-Prot P39634 (ROCA_BACSU)

Last modified November 25, 2008. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    1-pyrroline-5-carboxylate dehydrogenase
      Short name=P5C dehydrogenase
    EC=1.5.1.12
Gene names
Name: rocA
Ordered Locus Names: BSU37780
ORF Names: ipa-76d
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H.

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.

Induction

Expression is sigma L dependent and induced by arginine.

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RocA subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5155151-pyrroline-5-carboxylate dehydrogenase
PRO_0000056511

Sites

Active site2861 By similarity
Active site3201 By similarity

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Sequences

Sequence LengthMass (Da)Tools
P39634-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: C8115B4AEB4C979F

FASTA51556,320
        10         20         30         40         50         60 
MTVTYAHEPF TDFTEAKNKT AFGESLAFVN TQLGKHYPLV INGEKIETDR KIISINPANK 

        70         80         90        100        110        120 
EEIIGYASTA DQELAEKAMQ AALQAFDSWK KQRPEHRANI LFKAAAILRR RKHEFSSYLV 

       130        140        150        160        170        180 
KEAGKPWKEA DADTAEAIDF LEFYARQMLK LKEGAPVKSR AGEVNQYHYE ALGVGIVISP 

       190        200        210        220        230        240 
FNFPLAIMAG TAVAAIVTGN TILLKPADAA PVVAAKFVEV MEEAGLPNGV LNYIPGDGAE 

       250        260        270        280        290        300 
IGDFLVEHPK TRFVSFTGSR AVGCRIYERA AKVQPGQKWL KRVIAEMGGK DTVLVDKDAD 

       310        320        330        340        350        360 
LDLAASSIVY SAFGYSGQKC SAGSRAVIHQ DVYDEVVEKA VALTKTLTVG NPEDPDTYMG 

       370        380        390        400        410        420 
PVIHEASYNK VMKYIEIGKS EGKLLAGGEG DDSKGYFIQP TIFADVDENA RLMQEEIFGP 

       430        440        450        460        470        480 
VVAICKARDF DHMLEIANNT EYGLTGALLT KNRAHIERAR EDFHVGNLYF NRGCTGAIVG 

       490        500        510 
YQPFGGFNMS GTDSKAGGPD YLILHMQAKT TSEAF

« Hide

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References

« Hide 'large scale' references
[1]"Bacillus subtilis genome project: cloning and sequencing of the 97 kb region from 325 degrees to 333 degrees."
Glaser P., Kunst F., Arnaud M., Coudart M.P., Gonzales W., Hullo M.-F., Ionescu M., Lubochinsky B., Marcelino L., Moszer I., Presecan E., Santana M., Schneider E., Schweizer J., Vertes A., Rapoport G., Danchin A.
Mol. Microbiol. 10:371-384(1993) [PubMed: 7934828] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

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Cross-references

Sequence databases

X73124 Genomic DNA. Translation: CAA51632.1.
Z99123 Genomic DNA. Translation: CAB15805.1.
PIRS39731.
RefSeqNP_391658.1.

3D structure databases

HSSPHSSP built from PDB template 1AG8 based on UniProtKB P20000.
ModBaseSearch...

Genome annotation databases

GeneID937222.
GenomeReviewsGene locus BSU37780 in contig AL009126_GR.
KEGGbsu:BSU37780.
NMPDRfig|224308.1.peg.3784.

Organism-specific databases

SubtiListBG10622. rocA. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMP39634.

Enzyme and pathway databases

BioCycBSUB224308:BSU3775-MON.

Family and domain databases

HAMAPMF_00733.
[Tree]
InterProIPR016160. Ald_DHase_CS.
IPR016162. Ald_DHase_N.
IPR015590. Aldehyde_DHase.
IPR005932. d-1-pyrroline-5-COlate_DHase-2.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameROCA_BACSU
AccessionPrimary (citable) accession number: P39634
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 25, 2008
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents