Reviewed, UniProtKB/Swiss-Prot P39616 (ALDH2_BACSU)

Names and origin

Protein names

Recommended name:
    Probable aldehyde dehydrogenase ywdH
    EC=1.2.1.3

Gene names

Name:	ywdH
Ordered Locus Names:	BSU37960
ORF Names:	ipa-58r

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular aldehyde metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC aldehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Probable aldehyde dehydrogenase ywdH		PRO_0000056445
Sites
	Active site	210	1	By similarity
	Active site	244	1	By similarity
Experimental info
	Sequence conflict	2	1	N → NS in CAA51614. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P39616-1 [UniParc]. Last modified June 16, 2009. Version 2. Checksum: 78C8F36E6E6CB43B	FASTA	456	50,679
	10 20 30 40 50 60 MNSIPSIISK HKAYFAAGHT RPLESRLNIL RKLKQAVRTH EADLIAALYQ DLHKSEQEAY 70 80 90 100 110 120 STEIGIVLEE ISFVMKRLRK WSKPKRVKTP LTHLGSKSII IPEPYGTVLV IAPWNYPLQL 130 140 150 160 170 180 ALSPLIGAIA AGNTVVLKPS EYTPAVSAIL SKLISSVFPT DYVAMAEGGP DVSTALLQQP 190 200 210 220 230 240 FDYIFFTGSV AVGKIVMEAA AKQLIPVTLE LGGKSPCIVH KDADIQLAAK RIVFGKFTNA 250 260 270 280 290 300 GQTCIAPDYL FVHEDIKTKL TEEMKRAIRE FYGPQPERNP QYGKIVSERH YQRLLSFLND 310 320 330 340 350 360 GIPLTGGQSD PNHHKIAPTI LEQVRDDSPV MQEEIFGPIL PLFTYRNIGE VIEKVQSRPK 370 380 390 400 410 420 PLALYLFTTN KEIERAVLGN LSFGGGCVND TLMHVATPYL PFGGVGESGI GSYHGFDSFN 430 440 450 TFTHKKSVVK QTNRFDFAFR YPSSKNGLRM IRKILK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bacillus subtilis genome project: cloning and sequencing of the 97 kb region from 325 degrees to 333 degrees." Glaser P., Kunst F., Arnaud M., Coudart M.P., Gonzales W., Hullo M.-F., Ionescu M., Lubochinsky B., Marcelino L., Moszer I., Presecan E., Santana M., Schneider E., Schweizer J., Vertes A., Rapoport G., Danchin A. Mol. Microbiol. 10:371-384(1993) [PubMed: 7934828] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[3]	"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later." Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A. Microbiology 0:0-0(2009) [PubMed: 19383706] [Abstract] Cited for: SEQUENCE REVISION TO 2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X73124 Genomic DNA. Translation: CAA51614.1. AL009126 Genomic DNA. Translation: CAB15822.2.
PIR	S39713.
RefSeq	NP_391675.1.
3D structure databases
HSSP	HSSP built from PDB template 1AD3 based on UniProtKB P11883.
ModBase	Search...
Genome annotation databases
GeneID	937252.
GenomeReviews	Gene locus BSU37960 in contig AL009126_GR.
KEGG	bsu:BSU37960.
NMPDR	fig|224308.1.peg.3801.
Organism-specific databases
SubtiList	BG10604. ywdH. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	P39616.
OMA	P39616. PYTERAF.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU3792-MON.
BRENDA	1.2.1.3. 150.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR012394. Aldehyde_DH_NAD(P). [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF15. ALDH. 1 hit.
Pfam	PF00171. Aldedh. 2 hits. [Graphical view]
PIRSF	PIRSF036492. ALDH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH2_BACSU

Accession

Primary (citable) accession number: P39616

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	June 16, 2009
Last modified:	June 16, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)