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P39616

- ALDH2_BACSU

UniProt

P39616 - ALDH2_BACSU

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Protein

Probable aldehyde dehydrogenase YwdH

Gene

ywdH

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei210 – 2101By similarity
Active sitei244 – 2441By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
  2. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro

GO - Biological processi

  1. cellular aldehyde metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSUB:BSU37960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aldehyde dehydrogenase YwdH (EC:1.2.1.3)
Gene namesi
Name:ywdH
Ordered Locus Names:BSU37960
ORF Names:ipa-58r
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU37960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Probable aldehyde dehydrogenase YwdHPRO_0000056445Add
BLAST

Proteomic databases

PaxDbiP39616.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU37960.

Structurei

3D structure databases

ProteinModelPortaliP39616.
SMRiP39616. Positions 2-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271515.
InParanoidiP39616.
KOiK00128.
OrthoDBiEOG6BS8QW.
PhylomeDBiP39616.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39616 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSIPSIISK HKAYFAAGHT RPLESRLNIL RKLKQAVRTH EADLIAALYQ
60 70 80 90 100
DLHKSEQEAY STEIGIVLEE ISFVMKRLRK WSKPKRVKTP LTHLGSKSII
110 120 130 140 150
IPEPYGTVLV IAPWNYPLQL ALSPLIGAIA AGNTVVLKPS EYTPAVSAIL
160 170 180 190 200
SKLISSVFPT DYVAMAEGGP DVSTALLQQP FDYIFFTGSV AVGKIVMEAA
210 220 230 240 250
AKQLIPVTLE LGGKSPCIVH KDADIQLAAK RIVFGKFTNA GQTCIAPDYL
260 270 280 290 300
FVHEDIKTKL TEEMKRAIRE FYGPQPERNP QYGKIVSERH YQRLLSFLND
310 320 330 340 350
GIPLTGGQSD PNHHKIAPTI LEQVRDDSPV MQEEIFGPIL PLFTYRNIGE
360 370 380 390 400
VIEKVQSRPK PLALYLFTTN KEIERAVLGN LSFGGGCVND TLMHVATPYL
410 420 430 440 450
PFGGVGESGI GSYHGFDSFN TFTHKKSVVK QTNRFDFAFR YPSSKNGLRM

IRKILK
Length:456
Mass (Da):50,679
Last modified:June 16, 2009 - v2
Checksum:i78C8F36E6E6CB43B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21N → NS in CAA51614. (PubMed:7934828)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73124 Genomic DNA. Translation: CAA51614.1.
AL009126 Genomic DNA. Translation: CAB15822.2.
PIRiS39713.
RefSeqiNP_391675.2. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15822; CAB15822; BSU37960.
GeneIDi937252.
KEGGibsu:BSU37960.
PATRICi18979636. VBIBacSub10457_3980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73124 Genomic DNA. Translation: CAA51614.1 .
AL009126 Genomic DNA. Translation: CAB15822.2 .
PIRi S39713.
RefSeqi NP_391675.2. NC_000964.3.

3D structure databases

ProteinModelPortali P39616.
SMRi P39616. Positions 2-431.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU37960.

Proteomic databases

PaxDbi P39616.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15822 ; CAB15822 ; BSU37960 .
GeneIDi 937252.
KEGGi bsu:BSU37960.
PATRICi 18979636. VBIBacSub10457_3980.

Organism-specific databases

GenoListi BSU37960.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271515.
InParanoidi P39616.
KOi K00128.
OrthoDBi EOG6BS8QW.
PhylomeDBi P39616.

Enzyme and pathway databases

BioCyci BSUB:BSU37960-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
PIRSFi PIRSF036492. ALDH. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 2.

Entry informationi

Entry nameiALDH2_BACSU
AccessioniPrimary (citable) accession number: P39616
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3