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P39616

- ALDH2_BACSU

UniProt

P39616 - ALDH2_BACSU

Protein

Probable aldehyde dehydrogenase YwdH

Gene

ywdH

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei210 – 2101By similarity
    Active sitei244 – 2441By similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
    2. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro

    GO - Biological processi

    1. cellular aldehyde metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBSUB:BSU37960-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable aldehyde dehydrogenase YwdH (EC:1.2.1.3)
    Gene namesi
    Name:ywdH
    Ordered Locus Names:BSU37960
    ORF Names:ipa-58r
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU37960.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Probable aldehyde dehydrogenase YwdHPRO_0000056445Add
    BLAST

    Proteomic databases

    PaxDbiP39616.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU37960.

    Structurei

    3D structure databases

    ProteinModelPortaliP39616.
    SMRiP39616. Positions 2-431.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271515.
    KOiK00128.
    OrthoDBiEOG6BS8QW.
    PhylomeDBiP39616.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036492. ALDH. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39616-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSIPSIISK HKAYFAAGHT RPLESRLNIL RKLKQAVRTH EADLIAALYQ    50
    DLHKSEQEAY STEIGIVLEE ISFVMKRLRK WSKPKRVKTP LTHLGSKSII 100
    IPEPYGTVLV IAPWNYPLQL ALSPLIGAIA AGNTVVLKPS EYTPAVSAIL 150
    SKLISSVFPT DYVAMAEGGP DVSTALLQQP FDYIFFTGSV AVGKIVMEAA 200
    AKQLIPVTLE LGGKSPCIVH KDADIQLAAK RIVFGKFTNA GQTCIAPDYL 250
    FVHEDIKTKL TEEMKRAIRE FYGPQPERNP QYGKIVSERH YQRLLSFLND 300
    GIPLTGGQSD PNHHKIAPTI LEQVRDDSPV MQEEIFGPIL PLFTYRNIGE 350
    VIEKVQSRPK PLALYLFTTN KEIERAVLGN LSFGGGCVND TLMHVATPYL 400
    PFGGVGESGI GSYHGFDSFN TFTHKKSVVK QTNRFDFAFR YPSSKNGLRM 450
    IRKILK 456
    Length:456
    Mass (Da):50,679
    Last modified:June 16, 2009 - v2
    Checksum:i78C8F36E6E6CB43B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21N → NS in CAA51614. (PubMed:7934828)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73124 Genomic DNA. Translation: CAA51614.1.
    AL009126 Genomic DNA. Translation: CAB15822.2.
    PIRiS39713.
    RefSeqiNP_391675.2. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB15822; CAB15822; BSU37960.
    GeneIDi937252.
    KEGGibsu:BSU37960.
    PATRICi18979636. VBIBacSub10457_3980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73124 Genomic DNA. Translation: CAA51614.1 .
    AL009126 Genomic DNA. Translation: CAB15822.2 .
    PIRi S39713.
    RefSeqi NP_391675.2. NC_000964.3.

    3D structure databases

    ProteinModelPortali P39616.
    SMRi P39616. Positions 2-431.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU37960.

    Proteomic databases

    PaxDbi P39616.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15822 ; CAB15822 ; BSU37960 .
    GeneIDi 937252.
    KEGGi bsu:BSU37960.
    PATRICi 18979636. VBIBacSub10457_3980.

    Organism-specific databases

    GenoListi BSU37960.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271515.
    KOi K00128.
    OrthoDBi EOG6BS8QW.
    PhylomeDBi P39616.

    Enzyme and pathway databases

    BioCyci BSUB:BSU37960-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036492. ALDH. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
      Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
      Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 2.

    Entry informationi

    Entry nameiALDH2_BACSU
    AccessioniPrimary (citable) accession number: P39616
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3