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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.By similarity

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciBSUB:BSU37970-MONOMER
SABIO-RKiP39615

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase (EC:3.2.2.27)
Short name:
UDG
Gene namesi
Name:ung
Synonyms:ywdG
Ordered Locus Names:BSU37970
ORF Names:ipa-57d
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001760671 – 225Uracil-DNA glycosylaseAdd BLAST225

Proteomic databases

PaxDbiP39615
PRIDEiP39615

Interactioni

Subunit structurei

Interacts with bacillus phage phi29 protein p56; this interaction inhibits the uracil-DNA glycosylase.1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100020506

Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 17Combined sources11
Helixi20 – 35Combined sources16
Beta strandi38 – 40Combined sources3
Helixi42 – 44Combined sources3
Helixi47 – 51Combined sources5
Turni54 – 56Combined sources3
Beta strandi59 – 61Combined sources3
Turni70 – 72Combined sources3
Beta strandi75 – 78Combined sources4
Helixi88 – 100Combined sources13
Helixi112 – 116Combined sources5
Beta strandi123 – 125Combined sources3
Turni133 – 138Combined sources6
Helixi141 – 154Combined sources14
Beta strandi160 – 165Combined sources6
Helixi166 – 169Combined sources4
Helixi170 – 174Combined sources5
Turni177 – 179Combined sources3
Beta strandi181 – 185Combined sources5
Turni190 – 192Combined sources3
Helixi193 – 195Combined sources3
Turni196 – 199Combined sources4
Helixi202 – 212Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZOQX-ray1.45A1-225[»]
3ZORX-ray2.95A1-225[»]
ProteinModelPortaliP39615
SMRiP39615
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
InParanoidiP39615
KOiK03648
OMAiQANGLCF
PhylomeDBiP39615

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

P39615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQLLQDSWW NQLKEEFEKP YYQELREMLK REYAEQTIYP DSRDIFNALH
60 70 80 90 100
YTSYDDVKVV ILGQDPYHGP GQAQGLSFSV KPGVKQPPSL KNIFLELQQD
110 120 130 140 150
IGCSIPNHGS LVSWAKQGVL LLNTVLTVRR GQANSHKGKG WERLTDRIID
160 170 180 190 200
VLSERERPVI FILWGRHAQM KKERIDTSKH FIIESTHPSP FSARNGFFGS
210 220
RPFSRANAYL EKMGEAPIDW CIKDL
Length:225
Mass (Da):26,047
Last modified:February 1, 1995 - v1
Checksum:i649052A9C2904F9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73124 Genomic DNA Translation: CAA51613.1
AL009126 Genomic DNA Translation: CAB15823.1
PIRiS39712
RefSeqiNP_391676.1, NC_000964.3
WP_003242965.1, NZ_JNCM01000034.1

Genome annotation databases

EnsemblBacteriaiCAB15823; CAB15823; BSU37970
GeneIDi937265
KEGGibsu:BSU37970
PATRICifig|224308.179.peg.4111

Similar proteinsi

Entry informationi

Entry nameiUNG_BACSU
AccessioniPrimary (citable) accession number: P39615
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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