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P39615

- UNG_BACSU

UniProt

P39615 - UNG_BACSU

Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.By similarity

    Catalytic activityi

    Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Proton acceptorBy similarity

    GO - Molecular functioni

    1. uracil DNA N-glycosylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciBSUB:BSU37970-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil-DNA glycosylase (EC:3.2.2.27)
    Short name:
    UDG
    Gene namesi
    Name:ung
    Synonyms:ywdG
    Ordered Locus Names:BSU37970
    ORF Names:ipa-57d
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU37970. [Micado]

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 225225Uracil-DNA glycosylasePRO_0000176067Add
    BLAST

    Proteomic databases

    PaxDbiP39615.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU37970.

    Structurei

    Secondary structure

    1
    225
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 1711
    Helixi20 – 3516
    Beta strandi38 – 403
    Helixi42 – 443
    Helixi47 – 515
    Turni54 – 563
    Beta strandi59 – 613
    Turni70 – 723
    Beta strandi75 – 784
    Helixi88 – 10013
    Helixi112 – 1165
    Beta strandi123 – 1253
    Turni133 – 1386
    Helixi141 – 15414
    Beta strandi160 – 1656
    Helixi166 – 1694
    Helixi170 – 1745
    Turni177 – 1793
    Beta strandi181 – 1855
    Turni190 – 1923
    Helixi193 – 1953
    Turni196 – 1994
    Helixi202 – 21211

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZOQX-ray1.45A1-225[»]
    3ZORX-ray2.95A1-225[»]
    ProteinModelPortaliP39615.
    SMRiP39615. Positions 1-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the uracil-DNA glycosylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0692.
    HOGENOMiHOG000229528.
    KOiK03648.
    OMAiWARQGVM.
    OrthoDBiEOG6MSS63.
    PhylomeDBiP39615.

    Family and domain databases

    Gene3Di3.40.470.10. 1 hit.
    HAMAPiMF_00148. UDG.
    InterProiIPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view]
    PANTHERiPTHR11264. PTHR11264. 1 hit.
    PfamiPF03167. UDG. 1 hit.
    [Graphical view]
    SMARTiSM00986. UDG. 1 hit.
    [Graphical view]
    SUPFAMiSSF52141. SSF52141. 1 hit.
    TIGRFAMsiTIGR00628. ung. 1 hit.
    PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39615-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQLLQDSWW NQLKEEFEKP YYQELREMLK REYAEQTIYP DSRDIFNALH    50
    YTSYDDVKVV ILGQDPYHGP GQAQGLSFSV KPGVKQPPSL KNIFLELQQD 100
    IGCSIPNHGS LVSWAKQGVL LLNTVLTVRR GQANSHKGKG WERLTDRIID 150
    VLSERERPVI FILWGRHAQM KKERIDTSKH FIIESTHPSP FSARNGFFGS 200
    RPFSRANAYL EKMGEAPIDW CIKDL 225
    Length:225
    Mass (Da):26,047
    Last modified:February 1, 1995 - v1
    Checksum:i649052A9C2904F9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73124 Genomic DNA. Translation: CAA51613.1.
    AL009126 Genomic DNA. Translation: CAB15823.1.
    PIRiS39712.
    RefSeqiNP_391676.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB15823; CAB15823; BSU37970.
    GeneIDi937265.
    KEGGibsu:BSU37970.
    PATRICi18979638. VBIBacSub10457_3981.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73124 Genomic DNA. Translation: CAA51613.1 .
    AL009126 Genomic DNA. Translation: CAB15823.1 .
    PIRi S39712.
    RefSeqi NP_391676.1. NC_000964.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZOQ X-ray 1.45 A 1-225 [» ]
    3ZOR X-ray 2.95 A 1-225 [» ]
    ProteinModelPortali P39615.
    SMRi P39615. Positions 1-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU37970.

    Proteomic databases

    PaxDbi P39615.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15823 ; CAB15823 ; BSU37970 .
    GeneIDi 937265.
    KEGGi bsu:BSU37970.
    PATRICi 18979638. VBIBacSub10457_3981.

    Organism-specific databases

    GenoListi BSU37970. [Micado ]

    Phylogenomic databases

    eggNOGi COG0692.
    HOGENOMi HOG000229528.
    KOi K03648.
    OMAi WARQGVM.
    OrthoDBi EOG6MSS63.
    PhylomeDBi P39615.

    Enzyme and pathway databases

    BioCyci BSUB:BSU37970-MONOMER.

    Family and domain databases

    Gene3Di 3.40.470.10. 1 hit.
    HAMAPi MF_00148. UDG.
    InterProi IPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view ]
    PANTHERi PTHR11264. PTHR11264. 1 hit.
    Pfami PF03167. UDG. 1 hit.
    [Graphical view ]
    SMARTi SM00986. UDG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52141. SSF52141. 1 hit.
    TIGRFAMsi TIGR00628. ung. 1 hit.
    PROSITEi PS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiUNG_BACSU
    AccessioniPrimary (citable) accession number: P39615
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3