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P39583

- YWAC_BACSU

UniProt

P39583 - YWAC_BACSU

Protein

GTP pyrophosphokinase YwaC

Gene

ywaC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. activities in response to changes in nutritional abundance. YwaC has probably a minor role in stringent response.1 Publication

    Catalytic activityi

    ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. GTP binding Source: UniProtKB-KW
    3. GTP diphosphokinase activity Source: UniProtKB-EC
    4. kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBSUB:BSU38480-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP pyrophosphokinase YwaC (EC:2.7.6.5)
    Alternative name(s):
    (p)ppGpp synthase YwaC
    Small alarmone synthase 2
    Short name:
    SAS 2
    Gene namesi
    Name:ywaC
    Ordered Locus Names:BSU38480
    ORF Names:ipa-7d
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU38480.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210GTP pyrophosphokinase YwaCPRO_0000049949Add
    BLAST

    Proteomic databases

    PaxDbiP39583.

    Expressioni

    Inductioni

    Expressed during exponential growth with a marked and transient increase at the onset of the stationary phase. Induced by alkaline shock.1 Publication

    Interactioni

    Protein-protein interaction databases

    IntActiP39583. 1 interaction.
    STRINGi224308.BSU38480.

    Structurei

    3D structure databases

    ProteinModelPortaliP39583.
    SMRiP39583. Positions 16-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated

    Phylogenomic databases

    eggNOGiCOG2357.
    HOGENOMiHOG000263234.
    OMAiVRITCSF.
    OrthoDBiEOG6P5ZJ6.
    PhylomeDBiP39583.

    Family and domain databases

    InterProiIPR007685. RelA_SpoT.
    [Graphical view]
    PfamiPF04607. RelA_SpoT. 1 hit.
    [Graphical view]
    SMARTiSM00954. RelA_SpoT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39583-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLSVTHMDD LKTVMEDWKN ELLVYKFALD ALDTKFSIIS QEYNLIHGHN    50
    PIEHTKSRVK SFESIVNKLM RKGCEITTKE MKEHIHDIAG VRIICSFISD 100
    IYNVVNVLKQ HEDLRIVKVK DYIQTPKPNG YRSLHLIIEM PVNLTNRVEY 150
    VKAEIQIRTI AMDFWASLEH KIYYKLNNDV PKQLTDELKE AAEIAHYLDE 200
    KMLGIKKEVD 210
    Length:210
    Mass (Da):24,600
    Last modified:February 1, 1995 - v1
    Checksum:i6F981DF0D31A14FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73124 Genomic DNA. Translation: CAA51563.1.
    AL009126 Genomic DNA. Translation: CAB15874.1.
    PIRiS39662.
    RefSeqiNP_391727.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB15874; CAB15874; BSU38480.
    GeneIDi937355.
    KEGGibsu:BSU38480.
    PATRICi18979742. VBIBacSub10457_4033.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73124 Genomic DNA. Translation: CAA51563.1 .
    AL009126 Genomic DNA. Translation: CAB15874.1 .
    PIRi S39662.
    RefSeqi NP_391727.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali P39583.
    SMRi P39583. Positions 16-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P39583. 1 interaction.
    STRINGi 224308.BSU38480.

    Proteomic databases

    PaxDbi P39583.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB15874 ; CAB15874 ; BSU38480 .
    GeneIDi 937355.
    KEGGi bsu:BSU38480.
    PATRICi 18979742. VBIBacSub10457_4033.

    Organism-specific databases

    GenoListi BSU38480.

    Phylogenomic databases

    eggNOGi COG2357.
    HOGENOMi HOG000263234.
    OMAi VRITCSF.
    OrthoDBi EOG6P5ZJ6.
    PhylomeDBi P39583.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci BSUB:BSU38480-MONOMER.

    Family and domain databases

    InterProi IPR007685. RelA_SpoT.
    [Graphical view ]
    Pfami PF04607. RelA_SpoT. 1 hit.
    [Graphical view ]
    SMARTi SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilis."
      Nanamiya H., Kasai K., Nozawa A., Yun C.S., Narisawa T., Murakami K., Natori Y., Kawamura F., Tozawa Y.
      Mol. Microbiol. 67:291-304(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A (P)PPGPP SYNTHASE, INDUCTION.
      Strain: 168.

    Entry informationi

    Entry nameiYWAC_BACSU
    AccessioniPrimary (citable) accession number: P39583
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis. The synthase activity of YwaC is weaker than that of YjbM.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3