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P39581

- DLTA_BACSU

UniProt

P39581 - DLTA_BACSU

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Protein
D-alanine--poly(phosphoribitol) ligase subunit 1
Gene
dltA, dae, BSU38500, ipa-5r
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp.UniRule annotation

Catalytic activityi

ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate).UniRule annotation

Pathwayi

GO - Molecular functioni

  1. AMP binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. D-alanine-poly(phosphoribitol) ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipoteichoic acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU38500-MONOMER.
UniPathwayiUPA00556.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--poly(phosphoribitol) ligase subunit 1 (EC:6.1.1.13)
Alternative name(s):
D-alanine-D-alanyl carrier protein ligase
Short name:
DCL
D-alanine-activating enzyme
Short name:
DAE
Gene namesi
Name:dltA
Synonyms:dae
Ordered Locus Names:BSU38500
ORF Names:ipa-5r
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU38500. [Micado]

Subcellular locationi

Cytoplasm Inferred UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503D-alanine--poly(phosphoribitol) ligase subunit 1UniRule annotation
PRO_0000213142Add
BLAST

Proteomic databases

PaxDbiP39581.

Interactioni

Protein-protein interaction databases

IntActiP39581. 1 interaction.
MINTiMINT-8366705.
STRINGi224308.BSU38500.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1311
Beta strandi17 – 226
Beta strandi25 – 284
Helixi29 – 4315
Turni44 – 463
Beta strandi49 – 513
Beta strandi55 – 617
Helixi63 – 7513
Beta strandi79 – 835
Helixi88 – 9811
Beta strandi102 – 1087
Beta strandi120 – 1223
Helixi123 – 1275
Helixi136 – 1383
Beta strandi144 – 1518
Beta strandi159 – 1646
Helixi165 – 17814
Turni180 – 1845
Beta strandi186 – 1894
Helixi197 – 20711
Beta strandi211 – 2144
Helixi217 – 2215
Helixi223 – 23311
Beta strandi236 – 2405
Helixi242 – 2498
Turni256 – 2583
Beta strandi264 – 2674
Helixi274 – 28310
Beta strandi288 – 2914
Helixi296 – 2983
Beta strandi302 – 3076
Helixi309 – 3124
Beta strandi321 – 3233
Beta strandi328 – 3325
Beta strandi345 – 3517
Helixi362 – 3687
Beta strandi369 – 38719
Beta strandi390 – 40314
Beta strandi406 – 4094
Helixi410 – 41910
Beta strandi423 – 4319
Beta strandi433 – 4364
Beta strandi439 – 4468
Helixi454 – 46815
Helixi471 – 4733
Beta strandi476 – 4805
Helixi488 – 4903
Helixi494 – 50310

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E7WX-ray2.28A1-503[»]
3E7XX-ray2.60A1-503[»]
ProteinModelPortaliP39581.
SMRiP39581. Positions 1-503.

Miscellaneous databases

EvolutionaryTraceiP39581.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1020.
HOGENOMiHOG000229995.
KOiK03367.
OMAiPLVCIEK.
OrthoDBiEOG6QP0WP.
PhylomeDBiP39581.

Family and domain databases

HAMAPiMF_00593. DltA.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR010072. DltA.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR01734. D-ala-DACP-lig. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39581-1 [UniParc]FASTAAdd to Basket

« Hide

MKLLHAIQTH AETYPQTDAF RSQGQSLTYQ ELWEQSDRAA AAIQKRISGE    50
KKSPILVYGH MEPHMIVSFL GSVKAGHPYI PVDLSIPSER IAKIIESSGA 100
ELLIHAAGLS IDAVGQQIQT VSAEELLENE GGSVSQDQWV KEHETFYIIY 150
TSGSTGNPKG VQISAANLQS FTDWICADFP VSGGKIFLNQ APFSFDLSVM 200
DLYPCLQSGG TLHCVTKDAV NKPKVLFEEL KKSGLNVWTS TPSFVQMCLM 250
DPGFSQDLLP HADTFMFCGE VLPVSVAKAL LERFPKAKIF NTYGPTEATV 300
AVTSVEITND VISRSESLPV GFAKPDMNIF IMDEEGQPLP EGEKGEIVIA 350
GPSVSRGYLG EPELTEKAFF SHEGQWAYRT GDAGFIQDGQ IFCQGRLDFQ 400
IKLHGYRMEL EEIEFHVRQS QYVRSAVVIP YQPNGTVEYL IAAIVPEEHE 450
FEKEFQLTSA IKKELAASLP AYMIPRKFIY QDHIQMTANG KIDRKRIGEE 500
VLV 503
Length:503
Mass (Da):55,809
Last modified:February 1, 1995 - v1
Checksum:i76604AA90C812644
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73124 Genomic DNA. Translation: CAA51561.1.
AL009126 Genomic DNA. Translation: CAB15876.1.
PIRiS39660.
RefSeqiNP_391729.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15876; CAB15876; BSU38500.
GeneIDi937358.
KEGGibsu:BSU38500.
PATRICi18979748. VBIBacSub10457_4036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73124 Genomic DNA. Translation: CAA51561.1 .
AL009126 Genomic DNA. Translation: CAB15876.1 .
PIRi S39660.
RefSeqi NP_391729.1. NC_000964.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3E7W X-ray 2.28 A 1-503 [» ]
3E7X X-ray 2.60 A 1-503 [» ]
ProteinModelPortali P39581.
SMRi P39581. Positions 1-503.
ModBasei Search...

Protein-protein interaction databases

IntActi P39581. 1 interaction.
MINTi MINT-8366705.
STRINGi 224308.BSU38500.

Proteomic databases

PaxDbi P39581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15876 ; CAB15876 ; BSU38500 .
GeneIDi 937358.
KEGGi bsu:BSU38500.
PATRICi 18979748. VBIBacSub10457_4036.

Organism-specific databases

GenoListi BSU38500. [Micado ]

Phylogenomic databases

eggNOGi COG1020.
HOGENOMi HOG000229995.
KOi K03367.
OMAi PLVCIEK.
OrthoDBi EOG6QP0WP.
PhylomeDBi P39581.

Enzyme and pathway databases

UniPathwayi UPA00556 .
BioCyci BSUB:BSU38500-MONOMER.

Miscellaneous databases

EvolutionaryTracei P39581.

Family and domain databases

HAMAPi MF_00593. DltA.
InterProi IPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR010072. DltA.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01733. AA-adenyl-dom. 1 hit.
TIGR01734. D-ala-DACP-lig. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation."
    Perego M., Glaser P., Minutello A., Strauch M.A., Leopold K., Fischer W.
    J. Biol. Chem. 270:15598-15606(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiDLTA_BACSU
AccessioniPrimary (citable) accession number: P39581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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