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Protein

D-alanine--poly(phosphoribitol) ligase subunit 2

Gene

dltC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA.

Catalytic activityi

ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate).

Pathwayi: lipoteichoic acid biosynthesis

This protein is involved in the pathway lipoteichoic acid biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipoteichoic acid biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell wall biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU38520-MONOMER.
UniPathwayiUPA00556.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--poly(phosphoribitol) ligase subunit 2 (EC:6.1.1.13)
Alternative name(s):
D-alanyl carrier protein
Short name:
DCP
Gene namesi
Name:dltC
Ordered Locus Names:BSU38520
ORF Names:ipa-3r
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7878D-alanine--poly(phosphoribitol) ligase subunit 2PRO_0000213087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361O-(pantetheine 4'-phosphoryl)serineBy similarity

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP.By similarity

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDbiP39579.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100020796.

Structurei

Secondary structure

1
78
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1513Combined sources
Helixi19 – 224Combined sources
Turni28 – 325Combined sources
Helixi36 – 5015Combined sources
Helixi56 – 583Combined sources
Turni61 – 633Combined sources
Helixi67 – 7711Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BPFX-ray1.01A1-78[»]
4BPGX-ray2.20A/B1-78[»]
4BPHX-ray1.80A1-78[»]
ProteinModelPortaliP39579.
SMRiP39579. Positions 2-78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.Curated

Phylogenomic databases

eggNOGiCOG0236. LUCA.
HOGENOMiHOG000040491.
KOiK14188.
OMAiDEWNTPN.
PhylomeDBiP39579.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_00565. DltC. 1 hit.
InterProiIPR003230. DltC.
IPR009081. PP-bd_ACP.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01688. dltC. 1 hit.

Sequencei

Sequence statusi: Complete.

P39579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFKQEVLDV LAEVCQDDIV KENPDIEIFE EGLLDSFGTV ELLLAIENRF
60 70
DILVPITEFD RDVWNTPNNI VNQLSELK
Length:78
Mass (Da):9,009
Last modified:February 1, 1995 - v1
Checksum:i4A3F51C4A44CE8F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73124 Genomic DNA. Translation: CAA51559.1.
AL009126 Genomic DNA. Translation: CAB15878.1.
PIRiS39658.
RefSeqiNP_391731.1. NC_000964.3.
WP_003227325.1. NZ_JNCM01000034.1.

Genome annotation databases

EnsemblBacteriaiCAB15878; CAB15878; BSU38520.
GeneIDi11241460.
937361.
KEGGibsu:BSU38520.
PATRICi18979752. VBIBacSub10457_4038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73124 Genomic DNA. Translation: CAA51559.1.
AL009126 Genomic DNA. Translation: CAB15878.1.
PIRiS39658.
RefSeqiNP_391731.1. NC_000964.3.
WP_003227325.1. NZ_JNCM01000034.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BPFX-ray1.01A1-78[»]
4BPGX-ray2.20A/B1-78[»]
4BPHX-ray1.80A1-78[»]
ProteinModelPortaliP39579.
SMRiP39579. Positions 2-78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100020796.

Proteomic databases

PaxDbiP39579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15878; CAB15878; BSU38520.
GeneIDi11241460.
937361.
KEGGibsu:BSU38520.
PATRICi18979752. VBIBacSub10457_4038.

Phylogenomic databases

eggNOGiCOG0236. LUCA.
HOGENOMiHOG000040491.
KOiK14188.
OMAiDEWNTPN.
PhylomeDBiP39579.

Enzyme and pathway databases

UniPathwayiUPA00556.
BioCyciBSUB:BSU38520-MONOMER.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_00565. DltC. 1 hit.
InterProiIPR003230. DltC.
IPR009081. PP-bd_ACP.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01688. dltC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDLTC_BACSU
AccessioniPrimary (citable) accession number: P39579
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.