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Protein

Putative inosine-5'-monophosphate dehydrogenase 1

Gene

IMD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.

Cofactori

K(+)By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi330 – 3301Potassium; via carbonyl oxygenBy similarity
Metal bindingi332 – 3321Potassium; via carbonyl oxygenBy similarity
Binding sitei333 – 3331IMPBy similarity
Active sitei335 – 3351Thioimidate intermediateBy similarity
Metal bindingi335 – 3351Potassium; via carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi278 – 2803NADBy similarity
Nucleotide bindingi328 – 3303NADBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

ReactomeiREACT_235398. Purine ribonucleoside monophosphate biosynthesis.
UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inosine-5'-monophosphate dehydrogenase 1 (EC:1.1.1.205)
Short name:
IMP dehydrogenase 1
Short name:
IMPD 1
Short name:
IMPDH 1
Gene namesi
Name:IMD1
Ordered Locus Names:YAR073W
ORF Names:FUN63
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAR073w.
SGDiS000000095. IMD1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Putative inosine-5'-monophosphate dehydrogenase 1PRO_0000093681Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP39567.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

DIPiDIP-6455N.
IntActiP39567. 6 interactions.
MINTiMINT-705270.
STRINGi4932.YAR073W.

Structurei

3D structure databases

ProteinModelPortaliP39567.
SMRiP39567. Positions 10-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 18363CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini184 – 24057CBS 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 3703IMP bindingBy similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000062923.
HOGENOMiHOG000165752.
OMAiSICITQK.
OrthoDBiEOG793BHK.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIRDYKTA LDLTKSLPRP DGLSVQELMD SKIRGGLAYN DFLILPGLVD
60 70 80 90 100
FASSEVSLQT KLTRNITLNI PLVSSPMDTV TESEMATFMA LLDGIGFIHH
110 120 130 140 150
NCTPEDQADM VRRVKNYENG FINNPIVISP TTTVGEAKSM KEKYGFAGFP
160 170 180 190 200
VTADGKRNAK LVGAITSRDI QFVEDNSLLV QDVMTKNPVT GAQGITLSEG
210 220 230 240 250
NEILKKIKKG RLLVVDEKGN LVSMLSRTDL MKNQKYPLAS KSANTKQLLW
260 270 280 290 300
GASIGTMDAD KERLRLLVKA GLDVVILDSS QGNSIFQLNM IKWIKETFPD
310 320 330 340 350
LEIIAGNVVT KEQAANLIAA GADGLRIGMG TGSICITQKV MACGRPQGTA
360 370 380 390 400
VYNVCEFANQ FGVPCMADGG VQKHWSYYYQ SFGSWFFYCY DGWYVGRYYR

ITR
Length:403
Mass (Da):44,386
Last modified:February 1, 1995 - v1
Checksum:iFEBC13E46D5D1ECD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28920 Genomic DNA. Translation: AAC09509.1.
BK006935 Genomic DNA. No translation available.
PIRiS53477.

Genome annotation databases

EnsemblFungiiYAR073W; YAR073W; YAR073W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28920 Genomic DNA. Translation: AAC09509.1.
BK006935 Genomic DNA. No translation available.
PIRiS53477.

3D structure databases

ProteinModelPortaliP39567.
SMRiP39567. Positions 10-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6455N.
IntActiP39567. 6 interactions.
MINTiMINT-705270.
STRINGi4932.YAR073W.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAR073W; YAR073W; YAR073W.

Organism-specific databases

CYGDiYAR073w.
SGDiS000000095. IMD1.

Phylogenomic databases

GeneTreeiENSGT00530000062923.
HOGENOMiHOG000165752.
OMAiSICITQK.
OrthoDBiEOG793BHK.

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.
ReactomeiREACT_235398. Purine ribonucleoside monophosphate biosynthesis.

Gene expression databases

GenevestigatoriP39567.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region."
    Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast."
    Hyle J.W., Shaw R.J., Reines D.
    J. Biol. Chem. 278:28470-28478(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS PSEUDOGENE, LACK OF TRANSCRIPT.
  5. "Telomeric silencing of an open reading frame in Saccharomyces cerevisiae."
    Barton A.B., Kaback D.B.
    Genetics 173:1169-1173(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF TRANSCRIPT.

Entry informationi

Entry nameiIMDH1_YEAST
AccessioniPrimary (citable) accession number: P39567
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 4, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. In strain S288c, this gene has a frameshift compared to the other IMD alleles, producing 2 ORFs YAR073W and YAR075W. Additionally, YAR073W is not transcribed and lacks the biological functions of the other IMD genes even when artificially expressed.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.