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Protein

Putative inosine-5'-monophosphate dehydrogenase 1

Gene

IMD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.By similarity

Cofactori

K+By similarity

Pathwayi: XMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from IMP.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Inosine-5'-monophosphate dehydrogenase 2 (IMD2), Inosine-5'-monophosphate dehydrogenase 3 (IMD3), Inosine-5'-monophosphate dehydrogenase 4 (IMD4), Putative inosine-5'-monophosphate dehydrogenase 1 (IMD1)
This subpathway is part of the pathway XMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from IMP, the pathway XMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi330Potassium; via carbonyl oxygenBy similarity1
Metal bindingi332Potassium; via carbonyl oxygenBy similarity1
Binding sitei333IMPBy similarity1
Active sitei335Thioimidate intermediateBy similarity1
Metal bindingi335Potassium; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi278 – 280NADBy similarity3
Nucleotide bindingi328 – 330NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inosine-5'-monophosphate dehydrogenase 11 Publication (EC:1.1.1.205By similarity)
Short name:
IMP dehydrogenase 11 Publication
Short name:
IMPD 1
Short name:
IMPDH 1
Gene namesi
Name:IMD1
Ordered Locus Names:YAR073W
ORF Names:FUN63
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

SGDiS000000095. IMD1.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000936811 – 403Putative inosine-5'-monophosphate dehydrogenase 1Add BLAST403

Proteomic databases

MaxQBiP39567.
PRIDEiP39567.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

DIPiDIP-6455N.
IntActiP39567. 6 interactors.
MINTiMINT-705270.

Structurei

3D structure databases

ProteinModelPortaliP39567.
SMRiP39567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 183CBS 1PROSITE-ProRule annotationAdd BLAST63
Domaini184 – 240CBS 2PROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni368 – 370IMP bindingBy similarity3

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00840000131185.
HOGENOMiHOG000165752.
OMAiESANCIL.
OrthoDBiEOG092C1U8P.

Family and domain databases

CDDicd00381. IMPDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 2 hits.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIRDYKTA LDLTKSLPRP DGLSVQELMD SKIRGGLAYN DFLILPGLVD
60 70 80 90 100
FASSEVSLQT KLTRNITLNI PLVSSPMDTV TESEMATFMA LLDGIGFIHH
110 120 130 140 150
NCTPEDQADM VRRVKNYENG FINNPIVISP TTTVGEAKSM KEKYGFAGFP
160 170 180 190 200
VTADGKRNAK LVGAITSRDI QFVEDNSLLV QDVMTKNPVT GAQGITLSEG
210 220 230 240 250
NEILKKIKKG RLLVVDEKGN LVSMLSRTDL MKNQKYPLAS KSANTKQLLW
260 270 280 290 300
GASIGTMDAD KERLRLLVKA GLDVVILDSS QGNSIFQLNM IKWIKETFPD
310 320 330 340 350
LEIIAGNVVT KEQAANLIAA GADGLRIGMG TGSICITQKV MACGRPQGTA
360 370 380 390 400
VYNVCEFANQ FGVPCMADGG VQKHWSYYYQ SFGSWFFYCY DGWYVGRYYR

ITR
Length:403
Mass (Da):44,386
Last modified:February 1, 1995 - v1
Checksum:iFEBC13E46D5D1ECD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28920 Genomic DNA. Translation: AAC09509.1.
BK006935 Genomic DNA. No translation available.
PIRiS53477.

Genome annotation databases

EnsemblFungiiYAR073W; YAR073W; YAR073W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28920 Genomic DNA. Translation: AAC09509.1.
BK006935 Genomic DNA. No translation available.
PIRiS53477.

3D structure databases

ProteinModelPortaliP39567.
SMRiP39567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6455N.
IntActiP39567. 6 interactors.
MINTiMINT-705270.

Proteomic databases

MaxQBiP39567.
PRIDEiP39567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAR073W; YAR073W; YAR073W.

Organism-specific databases

SGDiS000000095. IMD1.

Phylogenomic databases

GeneTreeiENSGT00840000131185.
HOGENOMiHOG000165752.
OMAiESANCIL.
OrthoDBiEOG092C1U8P.

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Family and domain databases

CDDicd00381. IMPDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 2 hits.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMDH1_YEAST
AccessioniPrimary (citable) accession number: P39567
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. In strain S288c, this gene has a frameshift compared to the other IMD alleles, producing 2 ORFs YAR073W and YAR075W. Additionally, YAR073W is not transcribed and lacks the biological functions of the other IMD genes even when artificially expressed.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.