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P39567 (IMDH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative inosine-5'-monophosphate dehydrogenase 1

Short name=IMP dehydrogenase 1
Short name=IMPD 1
Short name=IMPDH 1
EC=1.1.1.205
Gene names
Name:IMD1
Ordered Locus Names:YAR073W
ORF Names:FUN63
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Catalytic activity

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.

Cofactor

Potassium By similarity.

Pathway

Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the IMPDH/GMPR family.

Contains 2 CBS domains.

Caution

Could be the product of a pseudogene. In strain S288c, this gene has a frameshift compared to the other IMD alleles, producing 2 ORFs YAR073W and YAR075W. Additionally, YAR073W is not transcribed and lacks the biological functions of the other IMD genes even when artificially expressed.

Ontologies

Keywords
   Biological processGMP biosynthesis
Purine biosynthesis
   Cellular componentCytoplasm
   DomainCBS domain
Repeat
   LigandMetal-binding
NAD
Potassium
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionadenyl nucleotide binding

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

oxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Putative inosine-5'-monophosphate dehydrogenase 1
PRO_0000093681

Regions

Domain121 – 18363CBS 1
Domain184 – 24057CBS 2
Nucleotide binding278 – 2803NAD By similarity
Nucleotide binding328 – 3303NAD By similarity
Region368 – 3703IMP binding By similarity

Sites

Active site3351Thioimidate intermediate By similarity
Metal binding3301Potassium; via carbonyl oxygen By similarity
Metal binding3321Potassium; via carbonyl oxygen By similarity
Metal binding3351Potassium; via carbonyl oxygen By similarity
Binding site3331IMP By similarity

Sequences

Sequence LengthMass (Da)Tools
P39567 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: FEBC13E46D5D1ECD

FASTA40344,386
        10         20         30         40         50         60 
MAAIRDYKTA LDLTKSLPRP DGLSVQELMD SKIRGGLAYN DFLILPGLVD FASSEVSLQT 

        70         80         90        100        110        120 
KLTRNITLNI PLVSSPMDTV TESEMATFMA LLDGIGFIHH NCTPEDQADM VRRVKNYENG 

       130        140        150        160        170        180 
FINNPIVISP TTTVGEAKSM KEKYGFAGFP VTADGKRNAK LVGAITSRDI QFVEDNSLLV 

       190        200        210        220        230        240 
QDVMTKNPVT GAQGITLSEG NEILKKIKKG RLLVVDEKGN LVSMLSRTDL MKNQKYPLAS 

       250        260        270        280        290        300 
KSANTKQLLW GASIGTMDAD KERLRLLVKA GLDVVILDSS QGNSIFQLNM IKWIKETFPD 

       310        320        330        340        350        360 
LEIIAGNVVT KEQAANLIAA GADGLRIGMG TGSICITQKV MACGRPQGTA VYNVCEFANQ 

       370        380        390        400 
FGVPCMADGG VQKHWSYYYQ SFGSWFFYCY DGWYVGRYYR ITR 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region."
Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W.
Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast."
Hyle J.W., Shaw R.J., Reines D.
J. Biol. Chem. 278:28470-28478(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS PSEUDOGENE, LACK OF TRANSCRIPT.
[5]"Telomeric silencing of an open reading frame in Saccharomyces cerevisiae."
Barton A.B., Kaback D.B.
Genetics 173:1169-1173(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: LACK OF TRANSCRIPT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L28920 Genomic DNA. Translation: AAC09509.1.
BK006935 Genomic DNA. No translation available.
PIRS53477.

3D structure databases

ProteinModelPortalP39567.
SMRP39567. Positions 10-372.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-6455N.
IntActP39567. 6 interactions.
MINTMINT-705270.
STRING4932.YAR073W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAR073W; YAR073W; YAR073W.

Organism-specific databases

CYGDYAR073w.
SGDS000000095. IMD1.

Phylogenomic databases

GeneTreeENSGT00530000062923.
HOGENOMHOG000165752.
OMASICITQK.
OrthoDBEOG793BHK.

Enzyme and pathway databases

UniPathwayUPA00601; UER00295.

Gene expression databases

GenevestigatorP39567.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
SMARTSM00116. CBS. 2 hits.
[Graphical view]
PROSITEPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIMDH1_YEAST
AccessionPrimary (citable) accession number: P39567
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways