Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P39567

- IMDH1_YEAST

UniProt

P39567 - IMDH1_YEAST

Protein

Putative inosine-5'-monophosphate dehydrogenase 1

Gene

IMD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.

    Cofactori

    Potassium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi330 – 3301Potassium; via carbonyl oxygenBy similarity
    Metal bindingi332 – 3321Potassium; via carbonyl oxygenBy similarity
    Binding sitei333 – 3331IMPBy similarity
    Active sitei335 – 3351Thioimidate intermediateBy similarity
    Metal bindingi335 – 3351Potassium; via carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi278 – 2803NADBy similarity
    Nucleotide bindingi328 – 3303NADBy similarity

    GO - Molecular functioni

    1. adenyl nucleotide binding Source: InterPro
    2. metal ion binding Source: UniProtKB-KW
    3. oxidoreductase activity Source: UniProtKB-KW

    GO - Biological processi

    1. GMP biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    GMP biosynthesis, Purine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Potassium

    Enzyme and pathway databases

    UniPathwayiUPA00601; UER00295.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative inosine-5'-monophosphate dehydrogenase 1 (EC:1.1.1.205)
    Short name:
    IMP dehydrogenase 1
    Short name:
    IMPD 1
    Short name:
    IMPDH 1
    Gene namesi
    Name:IMD1
    Ordered Locus Names:YAR073W
    ORF Names:FUN63
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAR073w.
    SGDiS000000095. IMD1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Putative inosine-5'-monophosphate dehydrogenase 1PRO_0000093681Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP39567.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    DIPiDIP-6455N.
    IntActiP39567. 6 interactions.
    MINTiMINT-705270.
    STRINGi4932.YAR073W.

    Structurei

    3D structure databases

    ProteinModelPortaliP39567.
    SMRiP39567. Positions 2-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini121 – 18363CBS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini184 – 24057CBS 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni368 – 3703IMP bindingBy similarity

    Sequence similaritiesi

    Belongs to the IMPDH/GMPR family.Curated
    Contains 2 CBS domains.PROSITE-ProRule annotation

    Keywords - Domaini

    CBS domain, Repeat

    Phylogenomic databases

    GeneTreeiENSGT00530000062923.
    HOGENOMiHOG000165752.
    OMAiSICITQK.
    OrthoDBiEOG793BHK.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view]
    PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
    PfamiPF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view]
    SMARTiSM00116. CBS. 2 hits.
    [Graphical view]
    PROSITEiPS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39567-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAIRDYKTA LDLTKSLPRP DGLSVQELMD SKIRGGLAYN DFLILPGLVD    50
    FASSEVSLQT KLTRNITLNI PLVSSPMDTV TESEMATFMA LLDGIGFIHH 100
    NCTPEDQADM VRRVKNYENG FINNPIVISP TTTVGEAKSM KEKYGFAGFP 150
    VTADGKRNAK LVGAITSRDI QFVEDNSLLV QDVMTKNPVT GAQGITLSEG 200
    NEILKKIKKG RLLVVDEKGN LVSMLSRTDL MKNQKYPLAS KSANTKQLLW 250
    GASIGTMDAD KERLRLLVKA GLDVVILDSS QGNSIFQLNM IKWIKETFPD 300
    LEIIAGNVVT KEQAANLIAA GADGLRIGMG TGSICITQKV MACGRPQGTA 350
    VYNVCEFANQ FGVPCMADGG VQKHWSYYYQ SFGSWFFYCY DGWYVGRYYR 400
    ITR 403
    Length:403
    Mass (Da):44,386
    Last modified:February 1, 1995 - v1
    Checksum:iFEBC13E46D5D1ECD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28920 Genomic DNA. Translation: AAC09509.1.
    BK006935 Genomic DNA. No translation available.
    PIRiS53477.

    Genome annotation databases

    EnsemblFungiiYAR073W; YAR073W; YAR073W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28920 Genomic DNA. Translation: AAC09509.1 .
    BK006935 Genomic DNA. No translation available.
    PIRi S53477.

    3D structure databases

    ProteinModelPortali P39567.
    SMRi P39567. Positions 2-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-6455N.
    IntActi P39567. 6 interactions.
    MINTi MINT-705270.
    STRINGi 4932.YAR073W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAR073W ; YAR073W ; YAR073W .

    Organism-specific databases

    CYGDi YAR073w.
    SGDi S000000095. IMD1.

    Phylogenomic databases

    GeneTreei ENSGT00530000062923.
    HOGENOMi HOG000165752.
    OMAi SICITQK.
    OrthoDBi EOG793BHK.

    Enzyme and pathway databases

    UniPathwayi UPA00601 ; UER00295 .

    Gene expression databases

    Genevestigatori P39567.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view ]
    PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
    Pfami PF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view ]
    SMARTi SM00116. CBS. 2 hits.
    [Graphical view ]
    PROSITEi PS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region."
      Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W.
      Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast."
      Hyle J.W., Shaw R.J., Reines D.
      J. Biol. Chem. 278:28470-28478(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS PSEUDOGENE, LACK OF TRANSCRIPT.
    5. "Telomeric silencing of an open reading frame in Saccharomyces cerevisiae."
      Barton A.B., Kaback D.B.
      Genetics 173:1169-1173(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF TRANSCRIPT.

    Entry informationi

    Entry nameiIMDH1_YEAST
    AccessioniPrimary (citable) accession number: P39567
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. In strain S288c, this gene has a frameshift compared to the other IMD alleles, producing 2 ORFs YAR073W and YAR075W. Additionally, YAR073W is not transcribed and lacks the biological functions of the other IMD genes even when artificially expressed.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3