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P39567

- IMDH1_YEAST

UniProt

P39567 - IMDH1_YEAST

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Protein

Putative inosine-5'-monophosphate dehydrogenase 1

Gene
IMD1, YAR073W, FUN63
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein uncertaini

Functioni

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.

Cofactori

Potassium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi330 – 3301Potassium; via carbonyl oxygen By similarity
Metal bindingi332 – 3321Potassium; via carbonyl oxygen By similarity
Binding sitei333 – 3331IMP By similarity
Active sitei335 – 3351Thioimidate intermediate By similarity
Metal bindingi335 – 3351Potassium; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi278 – 2803NAD By similarity
Nucleotide bindingi328 – 3303NAD By similarity

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inosine-5'-monophosphate dehydrogenase 1 (EC:1.1.1.205)
Short name:
IMP dehydrogenase 1
Short name:
IMPD 1
Short name:
IMPDH 1
Gene namesi
Name:IMD1
Ordered Locus Names:YAR073W
ORF Names:FUN63
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAR073w.
SGDiS000000095. IMD1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Putative inosine-5'-monophosphate dehydrogenase 1PRO_0000093681Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP39567.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

DIPiDIP-6455N.
IntActiP39567. 6 interactions.
MINTiMINT-705270.
STRINGi4932.YAR073W.

Structurei

3D structure databases

ProteinModelPortaliP39567.
SMRiP39567. Positions 2-403.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 18363CBS 1Add
BLAST
Domaini184 – 24057CBS 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 3703IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000062923.
HOGENOMiHOG000165752.
OMAiSICITQK.
OrthoDBiEOG793BHK.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39567-1 [UniParc]FASTAAdd to Basket

« Hide

MAAIRDYKTA LDLTKSLPRP DGLSVQELMD SKIRGGLAYN DFLILPGLVD    50
FASSEVSLQT KLTRNITLNI PLVSSPMDTV TESEMATFMA LLDGIGFIHH 100
NCTPEDQADM VRRVKNYENG FINNPIVISP TTTVGEAKSM KEKYGFAGFP 150
VTADGKRNAK LVGAITSRDI QFVEDNSLLV QDVMTKNPVT GAQGITLSEG 200
NEILKKIKKG RLLVVDEKGN LVSMLSRTDL MKNQKYPLAS KSANTKQLLW 250
GASIGTMDAD KERLRLLVKA GLDVVILDSS QGNSIFQLNM IKWIKETFPD 300
LEIIAGNVVT KEQAANLIAA GADGLRIGMG TGSICITQKV MACGRPQGTA 350
VYNVCEFANQ FGVPCMADGG VQKHWSYYYQ SFGSWFFYCY DGWYVGRYYR 400
ITR 403
Length:403
Mass (Da):44,386
Last modified:February 1, 1995 - v1
Checksum:iFEBC13E46D5D1ECD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28920 Genomic DNA. Translation: AAC09509.1.
BK006935 Genomic DNA. No translation available.
PIRiS53477.

Genome annotation databases

EnsemblFungiiYAR073W; YAR073W; YAR073W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28920 Genomic DNA. Translation: AAC09509.1 .
BK006935 Genomic DNA. No translation available.
PIRi S53477.

3D structure databases

ProteinModelPortali P39567.
SMRi P39567. Positions 2-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-6455N.
IntActi P39567. 6 interactions.
MINTi MINT-705270.
STRINGi 4932.YAR073W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAR073W ; YAR073W ; YAR073W .

Organism-specific databases

CYGDi YAR073w.
SGDi S000000095. IMD1.

Phylogenomic databases

GeneTreei ENSGT00530000062923.
HOGENOMi HOG000165752.
OMAi SICITQK.
OrthoDBi EOG793BHK.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .

Gene expression databases

Genevestigatori P39567.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region."
    Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast."
    Hyle J.W., Shaw R.J., Reines D.
    J. Biol. Chem. 278:28470-28478(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS PSEUDOGENE, LACK OF TRANSCRIPT.
  5. "Telomeric silencing of an open reading frame in Saccharomyces cerevisiae."
    Barton A.B., Kaback D.B.
    Genetics 173:1169-1173(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF TRANSCRIPT.

Entry informationi

Entry nameiIMDH1_YEAST
AccessioniPrimary (citable) accession number: P39567
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. In strain S288c, this gene has a frameshift compared to the other IMD alleles, producing 2 ORFs YAR073W and YAR075W. Additionally, YAR073W is not transcribed and lacks the biological functions of the other IMD genes even when artificially expressed.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3