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P39552

- MST28_YEAST

UniProt

P39552 - MST28_YEAST

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Protein
Multicopy suppressor of SEC21 protein 28
Gene
MST28, YAR033W, FUN59
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in protein trafficking vesicle formation, probably by stabilizing of coatomer at the Golgi membrane and thus allowing the efficient formation of COPI coated vesicles.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. vesicle organization Source: SGD
  3. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28882-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multicopy suppressor of SEC21 protein 28
Alternative name(s):
DUP240 protein MST28
Gene namesi
Name:MST28
Ordered Locus Names:YAR033W
ORF Names:FUN59
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAR033w.
SGDiS000000079. MST28.

Subcellular locationi

Endoplasmic reticulum. Golgi apparatus. Cytoplasmic vesicleCOPI-coated vesicle membrane; Multi-pass membrane protein Reviewed prediction. Cytoplasmic vesicleCOPII-coated vesicle membrane; Multi-pass membrane protein Reviewed prediction 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei48 – 6821Helical; Reviewed prediction
Add
BLAST
Topological domaini69 – 724Extracellular Reviewed prediction
Transmembranei73 – 9321Helical; Reviewed prediction
Add
BLAST
Topological domaini94 – 234141Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. COPI-coated vesicle membrane Source: UniProtKB-SubCell
  2. ER to Golgi transport vesicle membrane Source: UniProtKB-SubCell
  3. Golgi apparatus Source: SGD
  4. endoplasmic reticulum Source: SGD
  5. integral component of membrane Source: SGD
  6. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Multicopy suppressor of SEC21 protein 28
PRO_0000207526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39552.

Expressioni

Gene expression databases

GenevestigatoriP39552.

Interactioni

Subunit structurei

Interacts with MST27. Binds to coatomer proteins of COPI and SEC23/SEC24 of COPII coated vesicles.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MST27P531763EBI-20785,EBI-6205

Protein-protein interaction databases

BioGridi31810. 17 interactions.
DIPiDIP-1853N.
IntActiP39552. 6 interactions.
MINTiMINT-387935.
STRINGi4932.YAR033W.

Structurei

3D structure databases

ProteinModelPortaliP39552.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni231 – 2344COPI binding

Sequence similaritiesi

Belongs to the DUP/COS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017646.
HOGENOMiHOG000000896.
OrthoDBiEOG72JWSS.

Family and domain databases

InterProiIPR001142. DUP.
[Graphical view]
PfamiPF00674. DUP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39552-1 [UniParc]FASTAAdd to Basket

« Hide

MQTPPESTDV KLDTLNEPSA HLIEKNVALP KDIFRSYLSY WIYEIARYTP    50
VMILSLVIGV LVLLIIFFND NEACVFNSAI FAFTSLVGLL IILSDGNPKL 100
VSRRNFRTEL LVDVITRKPA VEGKEWRIIT YNMNQYLFNH GQWHTPYYFY 150
SDEDCYRYFL RLVEGVTPKK QTATSIGNSP VTAKPEDAIE SASPSSRLNY 200
QNFLLKAAEI ERQAQENYWR RRHPNIDALL KKTE 234
Length:234
Mass (Da):27,091
Last modified:February 1, 1995 - v1
Checksum:iB23AAD4D26831319
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28920 Genomic DNA. Translation: AAC09494.1.
BK006935 Genomic DNA. Translation: DAA07003.1.
PIRiS53484.
RefSeqiNP_009419.1. NM_001178225.1.

Genome annotation databases

EnsemblFungiiYAR033W; YAR033W; YAR033W.
GeneIDi851284.
KEGGisce:YAR033W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28920 Genomic DNA. Translation: AAC09494.1 .
BK006935 Genomic DNA. Translation: DAA07003.1 .
PIRi S53484.
RefSeqi NP_009419.1. NM_001178225.1.

3D structure databases

ProteinModelPortali P39552.
ModBasei Search...

Protein-protein interaction databases

BioGridi 31810. 17 interactions.
DIPi DIP-1853N.
IntActi P39552. 6 interactions.
MINTi MINT-387935.
STRINGi 4932.YAR033W.

Proteomic databases

MaxQBi P39552.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAR033W ; YAR033W ; YAR033W .
GeneIDi 851284.
KEGGi sce:YAR033W.

Organism-specific databases

CYGDi YAR033w.
SGDi S000000079. MST28.

Phylogenomic databases

GeneTreei ENSGT00390000017646.
HOGENOMi HOG000000896.
OrthoDBi EOG72JWSS.

Enzyme and pathway databases

BioCyci YEAST:G3O-28882-MONOMER.

Miscellaneous databases

NextBioi 968282.

Gene expression databases

Genevestigatori P39552.

Family and domain databases

InterProi IPR001142. DUP.
[Graphical view ]
Pfami PF00674. DUP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region."
    Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability."
    Poirey R., Despons L., Leh V., Lafuente M.-J., Potier S., Souciet J.-L., Jauniaux J.-C.
    Microbiology 148:2111-2123(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. "Suppression of coatomer mutants by a new protein family with COPI and COPII binding motifs in Saccharomyces cerevisiae."
    Sandmann T., Herrmann J.M., Dengjel J., Schwarz H., Spang A.
    Mol. Biol. Cell 14:3097-3113(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MST27.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMST28_YEAST
AccessioniPrimary (citable) accession number: P39552
Secondary accession number(s): D6VPN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

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