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Protein

Multicopy suppressor of SEC21 protein 28

Gene

MST28

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in protein trafficking vesicle formation, probably by stabilizing of coatomer at the Golgi membrane and thus allowing the efficient formation of COPI coated vesicles.1 Publication

Miscellaneous

Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • vesicle-mediated transport Source: UniProtKB-KW
  • vesicle organization Source: SGD

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28882-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Multicopy suppressor of SEC21 protein 28
Alternative name(s):
DUP240 protein MST28
Gene namesi
Name:MST28
Ordered Locus Names:YAR033W
ORF Names:FUN59
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAR033W
SGDiS000000079 MST28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 72ExtracellularSequence analysis4
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 234CytoplasmicSequence analysisAdd BLAST141

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075261 – 234Multicopy suppressor of SEC21 protein 28Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39552
PaxDbiP39552
PRIDEiP39552

PTM databases

iPTMnetiP39552

Interactioni

Subunit structurei

Interacts with MST27. Binds to coatomer proteins of COPI and SEC23/SEC24 of COPII coated vesicles.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MST27P531763EBI-20785,EBI-6205

Protein-protein interaction databases

BioGridi31810, 54 interactors
DIPiDIP-1853N
IntActiP39552, 6 interactors
MINTiP39552
STRINGi4932.YAR033W

Structurei

3D structure databases

ProteinModelPortaliP39552
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni231 – 234COPI binding4

Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017646
HOGENOMiHOG000000896
InParanoidiP39552
OrthoDBiEOG092C44UO

Family and domain databases

InterProiView protein in InterPro
IPR001142 DUP/COS
PfamiView protein in Pfam
PF00674 DUP, 1 hit

Sequencei

Sequence statusi: Complete.

P39552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTPPESTDV KLDTLNEPSA HLIEKNVALP KDIFRSYLSY WIYEIARYTP
60 70 80 90 100
VMILSLVIGV LVLLIIFFND NEACVFNSAI FAFTSLVGLL IILSDGNPKL
110 120 130 140 150
VSRRNFRTEL LVDVITRKPA VEGKEWRIIT YNMNQYLFNH GQWHTPYYFY
160 170 180 190 200
SDEDCYRYFL RLVEGVTPKK QTATSIGNSP VTAKPEDAIE SASPSSRLNY
210 220 230
QNFLLKAAEI ERQAQENYWR RRHPNIDALL KKTE
Length:234
Mass (Da):27,091
Last modified:February 1, 1995 - v1
Checksum:iB23AAD4D26831319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28920 Genomic DNA Translation: AAC09494.1
BK006935 Genomic DNA Translation: DAA07003.1
PIRiS53484
RefSeqiNP_009419.1, NM_001178225.1

Genome annotation databases

EnsemblFungiiYAR033W; YAR033W; YAR033W
GeneIDi851284
KEGGisce:YAR033W

Similar proteinsi

Entry informationi

Entry nameiMST28_YEAST
AccessioniPrimary (citable) accession number: P39552
Secondary accession number(s): D6VPN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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