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Protein

ULP1-interacting protein 3

Gene

UIP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1695 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

Enzyme and pathway databases

BioCyciYEAST:G3O-28878-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ULP1-interacting protein 3
Alternative name(s):
DUP240 protein UIP3
Gene namesi
Name:UIP3
Ordered Locus Names:YAR027W
ORF Names:FUN55
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAR027W.
SGDiS000000075. UIP3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075281 – 235ULP1-interacting protein 3Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP39547.
PRIDEiP39547.

PTM databases

iPTMnetiP39547.

Interactioni

Subunit structurei

Interacts with ULP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TMEM79Q9BSE23EBI-20760,EBI-8649725From Homo sapiens.

Protein-protein interaction databases

BioGridi31806. 98 interactors.
DIPiDIP-2031N.
IntActiP39547. 56 interactors.
MINTiMINT-516292.
STRINGi4932.YAR027W.

Structurei

3D structure databases

ProteinModelPortaliP39547.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017646.
HOGENOMiHOG000000896.
InParanoidiP39547.
OrthoDBiEOG092C44UO.

Family and domain databases

InterProiView protein in InterPro
IPR001142. DUP/COS.
PfamiView protein in Pfam
PF00674. DUP. 1 hit.

Sequencei

Sequence statusi: Complete.

P39547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTPSENTDV KLDTLDEPSA HLIEENVALP EDTFNSYWSY ILNEIARCKP
60 70 80 90 100
LMIMFLIPVC LVLLITFFHD IKGILVFLVI SLILSIIILL IGITAFVSET
110 120 130 140 150
LNKGFIIKLL VEVITRKPAV GGKEWRIIAY NMNQYLFDHG IWHTPYYFFC
160 170 180 190 200
EHRCHKFFKS LIKQTRSNAH LSSPTNGAEN TQSNTPAKEV SNEMVKPYIF
210 220 230
SSDPVLEAYL IKAAEIHKEA EFEYWRKQYP EVDLP
Length:235
Mass (Da):27,117
Last modified:February 1, 1995 - v1
Checksum:i9DBF29F9C2395AB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28920 Genomic DNA. Translation: AAC09489.1.
BK006935 Genomic DNA. Translation: DAA06999.1.
PIRiS53479.
RefSeqiNP_009414.1. NM_001178221.1.

Genome annotation databases

EnsemblFungiiYAR027W; YAR027W; YAR027W.
GeneIDi851279.
KEGGisce:YAR027W.

Similar proteinsi

Entry informationi

Entry nameiUIP3_YEAST
AccessioniPrimary (citable) accession number: P39547
Secondary accession number(s): D6VPM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 27, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names