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P39547

- UIP3_YEAST

UniProt

P39547 - UIP3_YEAST

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Protein

ULP1-interacting protein 3

Gene

UIP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-28878-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ULP1-interacting protein 3
Alternative name(s):
DUP240 protein UIP3
Gene namesi
Name:UIP3
Ordered Locus Names:YAR027W
ORF Names:FUN55
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAR027w.
SGDiS000000075. UIP3.

Subcellular locationi

Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nuclear envelope Source: SGD
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235ULP1-interacting protein 3PRO_0000207528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki218 – 218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP39547.
PaxDbiP39547.

Expressioni

Gene expression databases

GenevestigatoriP39547.

Interactioni

Subunit structurei

Interacts with ULP1.1 Publication

Protein-protein interaction databases

BioGridi31806. 74 interactions.
DIPiDIP-2031N.
IntActiP39547. 52 interactions.
MINTiMINT-516292.
STRINGi4932.YAR027W.

Structurei

3D structure databases

ProteinModelPortaliP39547.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017646.
HOGENOMiHOG000000896.
InParanoidiP39547.
OrthoDBiEOG72JWSS.

Family and domain databases

InterProiIPR001142. DUP.
[Graphical view]
PfamiPF00674. DUP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39547-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTPSENTDV KLDTLDEPSA HLIEENVALP EDTFNSYWSY ILNEIARCKP
60 70 80 90 100
LMIMFLIPVC LVLLITFFHD IKGILVFLVI SLILSIIILL IGITAFVSET
110 120 130 140 150
LNKGFIIKLL VEVITRKPAV GGKEWRIIAY NMNQYLFDHG IWHTPYYFFC
160 170 180 190 200
EHRCHKFFKS LIKQTRSNAH LSSPTNGAEN TQSNTPAKEV SNEMVKPYIF
210 220 230
SSDPVLEAYL IKAAEIHKEA EFEYWRKQYP EVDLP
Length:235
Mass (Da):27,117
Last modified:February 1, 1995 - v1
Checksum:i9DBF29F9C2395AB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28920 Genomic DNA. Translation: AAC09489.1.
BK006935 Genomic DNA. Translation: DAA06999.1.
PIRiS53479.
RefSeqiNP_009414.1. NM_001178221.1.

Genome annotation databases

EnsemblFungiiYAR027W; YAR027W; YAR027W.
GeneIDi851279.
KEGGisce:YAR027W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28920 Genomic DNA. Translation: AAC09489.1 .
BK006935 Genomic DNA. Translation: DAA06999.1 .
PIRi S53479.
RefSeqi NP_009414.1. NM_001178221.1.

3D structure databases

ProteinModelPortali P39547.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31806. 74 interactions.
DIPi DIP-2031N.
IntActi P39547. 52 interactions.
MINTi MINT-516292.
STRINGi 4932.YAR027W.

Proteomic databases

MaxQBi P39547.
PaxDbi P39547.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAR027W ; YAR027W ; YAR027W .
GeneIDi 851279.
KEGGi sce:YAR027W.

Organism-specific databases

CYGDi YAR027w.
SGDi S000000075. UIP3.

Phylogenomic databases

GeneTreei ENSGT00390000017646.
HOGENOMi HOG000000896.
InParanoidi P39547.
OrthoDBi EOG72JWSS.

Enzyme and pathway databases

BioCyci YEAST:G3O-28878-MONOMER.

Miscellaneous databases

NextBioi 968270.

Gene expression databases

Genevestigatori P39547.

Family and domain databases

InterProi IPR001142. DUP.
[Graphical view ]
Pfami PF00674. DUP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region."
    Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins."
    Takahashi Y., Mizoi J., Toh-e A., Kikuchi Y.
    J. Biochem. 128:723-725(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ULP1.
  5. "Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability."
    Poirey R., Despons L., Leh V., Lafuente M.-J., Potier S., Souciet J.-L., Jauniaux J.-C.
    Microbiology 148:2111-2123(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-11 AND LYS-218.
    Strain: SUB592.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUIP3_YEAST
AccessioniPrimary (citable) accession number: P39547
Secondary accession number(s): D6VPM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1695 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3