Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P39547

- UIP3_YEAST

UniProt

P39547 - UIP3_YEAST

Protein

ULP1-interacting protein 3

Gene

UIP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28878-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ULP1-interacting protein 3
    Alternative name(s):
    DUP240 protein UIP3
    Gene namesi
    Name:UIP3
    Ordered Locus Names:YAR027W
    ORF Names:FUN55
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAR027w.
    SGDiS000000075. UIP3.

    Subcellular locationi

    Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. nuclear envelope Source: SGD
    3. nuclear membrane Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235ULP1-interacting protein 3PRO_0000207528Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki218 – 218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiP39547.
    PaxDbiP39547.

    Expressioni

    Gene expression databases

    GenevestigatoriP39547.

    Interactioni

    Subunit structurei

    Interacts with ULP1.1 Publication

    Protein-protein interaction databases

    BioGridi31806. 74 interactions.
    DIPiDIP-2031N.
    IntActiP39547. 52 interactions.
    MINTiMINT-516292.
    STRINGi4932.YAR027W.

    Structurei

    3D structure databases

    ProteinModelPortaliP39547.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DUP/COS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00390000017646.
    HOGENOMiHOG000000896.
    OrthoDBiEOG72JWSS.

    Family and domain databases

    InterProiIPR001142. DUP.
    [Graphical view]
    PfamiPF00674. DUP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39547-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTPSENTDV KLDTLDEPSA HLIEENVALP EDTFNSYWSY ILNEIARCKP    50
    LMIMFLIPVC LVLLITFFHD IKGILVFLVI SLILSIIILL IGITAFVSET 100
    LNKGFIIKLL VEVITRKPAV GGKEWRIIAY NMNQYLFDHG IWHTPYYFFC 150
    EHRCHKFFKS LIKQTRSNAH LSSPTNGAEN TQSNTPAKEV SNEMVKPYIF 200
    SSDPVLEAYL IKAAEIHKEA EFEYWRKQYP EVDLP 235
    Length:235
    Mass (Da):27,117
    Last modified:February 1, 1995 - v1
    Checksum:i9DBF29F9C2395AB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28920 Genomic DNA. Translation: AAC09489.1.
    BK006935 Genomic DNA. Translation: DAA06999.1.
    PIRiS53479.
    RefSeqiNP_009414.1. NM_001178221.1.

    Genome annotation databases

    EnsemblFungiiYAR027W; YAR027W; YAR027W.
    GeneIDi851279.
    KEGGisce:YAR027W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28920 Genomic DNA. Translation: AAC09489.1 .
    BK006935 Genomic DNA. Translation: DAA06999.1 .
    PIRi S53479.
    RefSeqi NP_009414.1. NM_001178221.1.

    3D structure databases

    ProteinModelPortali P39547.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31806. 74 interactions.
    DIPi DIP-2031N.
    IntActi P39547. 52 interactions.
    MINTi MINT-516292.
    STRINGi 4932.YAR027W.

    Proteomic databases

    MaxQBi P39547.
    PaxDbi P39547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAR027W ; YAR027W ; YAR027W .
    GeneIDi 851279.
    KEGGi sce:YAR027W.

    Organism-specific databases

    CYGDi YAR027w.
    SGDi S000000075. UIP3.

    Phylogenomic databases

    GeneTreei ENSGT00390000017646.
    HOGENOMi HOG000000896.
    OrthoDBi EOG72JWSS.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28878-MONOMER.

    Miscellaneous databases

    NextBioi 968270.

    Gene expression databases

    Genevestigatori P39547.

    Family and domain databases

    InterProi IPR001142. DUP.
    [Graphical view ]
    Pfami PF00674. DUP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region."
      Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W.
      Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins."
      Takahashi Y., Mizoi J., Toh-e A., Kikuchi Y.
      J. Biochem. 128:723-725(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ULP1.
    5. "Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability."
      Poirey R., Despons L., Leh V., Lafuente M.-J., Potier S., Souciet J.-L., Jauniaux J.-C.
      Microbiology 148:2111-2123(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-11 AND LYS-218.
      Strain: SUB592.
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUIP3_YEAST
    AccessioniPrimary (citable) accession number: P39547
    Secondary accession number(s): D6VPM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1695 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3