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P39543 (SOP4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein SOP4
Alternative name(s):
Suppressor of PMA1-7 protein 4
Gene names
Name:SOP4
Ordered Locus Names:YJL192C
ORF Names:J0351
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the export of PMA1, possibly through the monitoring or assisting of PMA1 folding and acquisition of competence to enter vesicles. Ref.5 Ref.6

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein Ref.6 Ref.7.

Miscellaneous

Present with 11700 molecules/cell in log phase SD medium. Ref.8

Sequence similarities

Belongs to the SOP4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 234216Protein SOP4
PRO_0000014332

Regions

Topological domain19 – 188170Lumenal Potential
Transmembrane189 – 20921Helical; Potential
Topological domain210 – 23425Cytoplasmic Potential

Amino acid modifications

Glycosylation351N-linked (GlcNAc...) Potential
Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation851N-linked (GlcNAc...) Potential
Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation1701N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P39543 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: A29CA99FA3741A41

FASTA23426,598
        10         20         30         40         50         60 
MFSQIVLLLS AFIYVASATA RRGTIKGRLD LAASNITGFV STRTSFKLYQ IGNFSTEYPY 

        70         80         90        100        110        120 
TSTTMFQDDE GNFEFANLPL NDGVNETTYY VMYPASMDFN LKPNRILIEF KNLENGTLQL 

       130        140        150        160        170        180 
NAFKNFFGRE YFPSKDITYP EKLQSMKVHP YITVELLHKA PIRSYLQARN VSIFSTGIVG 

       190        200        210        220        230 
NILNSRWKLA GVITLIALVV FPIIVEKLDP ETARAIREEA KRKQREKYAA VASK

« Hide

References

« Hide 'large scale' references
[1]"The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes."
Purnelle B., Coster F., Goffeau A.
Yeast 10:1235-1249(1994) [PubMed: 7754713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Novel genes involved in endosomal traffic in yeast revealed by suppression of a targeting-defective plasma membrane ATPase mutant."
Luo W.-J., Chang A.
J. Cell Biol. 138:731-746(1997) [PubMed: 9265642] [Abstract]
Cited for: FUNCTION.
[6]"An ER membrane protein, Sop4, facilitates ER export of the yeast plasma membrane [H+]ATPase, Pma1."
Luo W.J., Gong X.H., Chang A.
Traffic 3:730-739(2002) [PubMed: 12230471] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X77688 Genomic DNA. Translation: CAA54768.1.
Z49467 Genomic DNA. Translation: CAA89487.1.
AY693041 Genomic DNA. Translation: AAT93060.1.
BK006943 Genomic DNA. Translation: DAA08615.1.
PIRS46642.
RefSeqNP_012343.1. NM_001181625.1.

3D structure databases

ProteinModelPortalP39543.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5094N.
IntActP39543. 25 interactions.
MINTMINT-571759.
STRINGP39543.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL192C; YJL192C; YJL192C.
GeneID853247.
KEGGsce:YJL192C.
NMPDRfig|4932.3.peg.3307.

Organism-specific databases

CYGDYJL192c.
SGDS000003728. SOP4.

Phylogenomic databases

eggNOGfuNOG10054.
HOGENOMHBG202246.
OMAGREYFPS.
OrthoDBEOG41K2NS.

Gene expression databases

ArrayExpressP39543.
GenevestigatorP39543.
GermOnlineYJL192C. Saccharomyces cerevisiae.

Family and domain databases

ProtoNetSearch...

Other

NextBio973484.

Entry information

Entry nameSOP4_YEAST
AccessionPrimary (citable) accession number: P39543
Secondary accession number(s): D6VVZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 14, 2011
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents