Reviewed, UniProtKB/Swiss-Prot P39542 (YJT3_YEAST)

Names and origin

Protein names

Recommended name:
    Uncharacterized transporter YJL193W

Gene names

Ordered Locus Names:	YJL193W
ORF Names:	J0349

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the TPT transporter family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Uncharacterized transporter YJL193W		PRO_0000206786
Regions
	Topological domain	1 – 12	12	Cytoplasmic Potential
	Transmembrane	13 – 33	21	Potential
	Topological domain	34 – 50	17	Extracellular Potential
	Transmembrane	51 – 71	21	Potential
	Topological domain	72 – 103	32	Cytoplasmic Potential
	Transmembrane	104 – 124	21	Potential
	Topological domain	125 – 134	10	Extracellular Potential
	Transmembrane	135 – 155	21	Potential
	Topological domain	156 – 165	10	Cytoplasmic Potential
	Transmembrane	166 – 186	21	Potential
	Topological domain	187 – 206	20	Extracellular Potential
	Transmembrane	207 – 227	21	Potential
	Topological domain	228 – 271	44	Cytoplasmic Potential
	Transmembrane	272 – 292	21	Potential
	Topological domain	293 – 353	61	Extracellular Potential
	Transmembrane	354 – 374	21	Potential
	Topological domain	375 – 402	28	Cytoplasmic Potential
Amino acid modifications
	Modified residue	247	1	Phosphoserine Ref.4 Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P39542-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 3C8A1C2BFEB70F2A	FASTA	402	45,937
	10 20 30 40 50 60 MFQQLSASIR HNAHIIFLCI SWYFISSLAS QVTKQVLTVC PLPLFLGEFQ FIYTAVLAWF 70 80 90 100 110 120 TCYIAYSFPG FYRIFPNGTF PEYYIDDRET SRAARKESKL SSLIIPPSKP ILQTVLPLGL 130 140 150 160 170 180 FQFVGKYFGH TATSLVPVST VASIKTLSPM FILLLQKILK ISTLKITLTL IFSLCTLVLG 190 200 210 220 230 240 VWIIVQEDNR SPASSNELRE FSKYGVICAM ISMFIFVLQN IYGKTVFTYR SQTDESQSNS 250 260 270 280 290 300 GFSRQESPLP LYEKLDEKLV AKKKPKSYDK LTLMIYISLV GFCLSFGWFI TLEFPVLFRY 310 320 330 340 350 360 FFQINSSSTV IKAFPVSLFL LNGTFHFIQA MITFHLLGEV STLTYSIANL MKRFAIIAVS 370 380 390 400 WVFIGRRITW LQVFGLVLNT LGLFLYERCT SQSKIKAKIR PE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes." Purnelle B., Coster F., Goffeau A. Yeast 10:1235-1249(1994) [PubMed: 7754713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
[4]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, MASS SPECTROMETRY.
[5]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X77688 Genomic DNA. Translation: CAA54767.1. Z49468 Genomic DNA. Translation: CAA89488.1.
PIR	S46641.
RefSeq	NP_012342.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:7379N.
STRING	P39542.
Proteomic databases
PRIDE	P39542.
Genome annotation databases
Ensembl	YJL193W; YJL193W; YJL193W; Saccharomyces cerevisiae. [Genome view]
GeneID	853246.
KEGG	sce:YJL193W.
NMPDR	fig|4932.3.peg.3306.
Organism-specific databases
CYGD	YJL193w.
SGD	S000003729. YJL193W.
Phylogenomic databases
HOGENOM	P39542.
OMA	VAVCHAI
OrthoDB	EOG9SBGFG
Gene expression databases
ArrayExpress	P39542.
Genevestigator	P39542.
GermOnline	YJL193W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR004853. DUF250. IPR004696. Tpt_PEP_transl. [Graphical view]
Pfam	PF03151. TPT. 1 hit. [Graphical view]
TIGRFAMs	TIGR00817. tpt. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	973481.

Entry information

Entry name

YJT3_YEAST

Accession

Primary (citable) accession number: P39542

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 24, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)