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P39540 (ELO1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation of fatty acids protein 1

EC=2.3.1.199
Alternative name(s):
3-keto acyl-CoA synthase ELO1
Very-long-chain 3-oxoacyl-CoA synthase 1
Gene names
Name:ELO1
Ordered Locus Names:YJL196C
ORF Names:J0343
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a membrane bound enzyme involved in the highly specific elongation of saturated 14-carbon fatty acids (14:0) to 16-carbon species (16:0).

Catalytic activity

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Induction

Induced in wild-type cells supplemented with 14:0 fatty acids and repressed when cells are supplied with 16- and 18-carbon fatty acids.

Miscellaneous

Present with 937 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the ELO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Elongation of fatty acids protein 1
PRO_0000207548

Regions

Topological domain1 – 6363Extracellular Potential
Transmembrane64 – 8421Helical; Potential
Topological domain85 – 10016Cytoplasmic Potential
Transmembrane101 – 12121Helical; Potential
Topological domain122 – 18665Extracellular Potential
Transmembrane187 – 20721Helical; Potential
Topological domain208 – 23427Cytoplasmic Potential
Transmembrane235 – 25521Helical; Potential
Topological domain256 – 27116Extracellular Potential
Transmembrane272 – 29221Helical; Potential
Topological domain293 – 31018Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P39540 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 051D5369976BF48F

FASTA31036,234
        10         20         30         40         50         60 
MVSDWKNFCL EKASRFRPTI DRPFFNIYLW DYFNRAVGWA TAGRFQPKDF EFTVGKQPLS 

        70         80         90        100        110        120 
EPRPVLLFIA MYYVVIFGGR SLVKSCKPLK LRFISQVHNL MLTSVSFLWL ILMVEQMLPI 

       130        140        150        160        170        180 
VYRHGLYFAV CNVESWTQPM ETLYYLNYMT KFVEFADTVL MVLKHRKLTF LHTYHHGATA 

       190        200        210        220        230        240 
LLCYNQLVGY TAVTWVPVTL NLAVHVLMYW YYFLSASGIR VWWKAWVTRL QIVQFMLDLI 

       250        260        270        280        290        300 
VVYYVLYQKI VAAYFKNACT PQCEDCLGSM TAIAAGAAIL TSYLFLFISF YIEVYKRGSA 

       310 
SGKKKINKNN 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae."
Toke D.A., Martin C.E.
J. Biol. Chem. 271:18413-18422(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[2]"The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes."
Purnelle B., Coster F., Goffeau A.
Yeast 10:1235-1249(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X77688 Genomic DNA. Translation: CAA54764.1.
Z49471 Genomic DNA. Translation: CAA89491.1.
BK006943 Genomic DNA. Translation: DAA08612.1.
PIRS46638.
RefSeqNP_012339.1. NM_001181629.1.

3D structure databases

ProteinModelPortalP39540.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33568. 72 interactions.
DIPDIP-8755N.
IntActP39540. 5 interactions.
MINTMINT-1357650.
STRING4932.YJL196C.

Proteomic databases

MaxQBP39540.
PaxDbP39540.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL196C; YJL196C; YJL196C.
GeneID853243.
KEGGsce:YJL196C.

Organism-specific databases

CYGDYJL196c.
SGDS000003732. ELO1.

Phylogenomic databases

eggNOGNOG305096.
GeneTreeENSGT00740000115027.
HOGENOMHOG000160635.
KOK10245.
OMALLMHICI.
OrthoDBEOG7F51CG.

Enzyme and pathway databases

BioCycYEAST:G3O-31627-MONOMER.

Gene expression databases

GenevestigatorP39540.

Family and domain databases

InterProIPR002076. GNS1_SUR4.
[Graphical view]
PANTHERPTHR11157. PTHR11157. 1 hit.
PfamPF01151. ELO. 1 hit.
[Graphical view]
PROSITEPS01188. ELO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973475.
PROP39540.

Entry information

Entry nameELO1_YEAST
AccessionPrimary (citable) accession number: P39540
Secondary accession number(s): D6VVZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families