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P39540

- ELO1_YEAST

UniProt

P39540 - ELO1_YEAST

Protein

Elongation of fatty acids protein 1

Gene

ELO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    May be a membrane bound enzyme involved in the highly specific elongation of saturated 14-carbon fatty acids (14:0) to 16-carbon species (16:0).

    Catalytic activityi

    A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.

    GO - Molecular functioni

    1. fatty acid elongase activity Source: SGD

    GO - Biological processi

    1. fatty acid elongation, unsaturated fatty acid Source: SGD

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31627-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation of fatty acids protein 1 (EC:2.3.1.199)
    Alternative name(s):
    3-keto acyl-CoA synthase ELO1
    Very-long-chain 3-oxoacyl-CoA synthase 1
    Gene namesi
    Name:ELO1
    Ordered Locus Names:YJL196C
    ORF Names:J0343
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL196c.
    SGDiS000003732. ELO1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Elongation of fatty acids protein 1PRO_0000207548Add
    BLAST

    Proteomic databases

    MaxQBiP39540.
    PaxDbiP39540.

    Expressioni

    Inductioni

    Induced in wild-type cells supplemented with 14:0 fatty acids and repressed when cells are supplied with 16- and 18-carbon fatty acids.

    Gene expression databases

    GenevestigatoriP39540.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CHO1P084561EBI-2049096,EBI-14055
    CHO2P053741EBI-2049096,EBI-2049142
    DAL5P153651EBI-2049096,EBI-5527
    ERG11P106141EBI-2049096,EBI-5127
    ERG25P530451EBI-2049096,EBI-6506
    ERG5P547811EBI-2049096,EBI-6563
    ERP1Q053591EBI-2049096,EBI-6581
    ERV25P548371EBI-2049096,EBI-6642
    GAP1P191451EBI-2049096,EBI-7314
    ORM2Q061441EBI-2049096,EBI-34916
    PHO88P382641EBI-2049096,EBI-13350
    PIS1P061971EBI-2049096,EBI-13458
    SAC1P323681EBI-2049096,EBI-16210
    SCS7Q035291EBI-2049096,EBI-16747
    SPC1P469651EBI-2049096,EBI-17823
    SPC2Q049691EBI-2049096,EBI-27827
    SPF1P399861EBI-2049096,EBI-3128
    SWP1Q027951EBI-2049096,EBI-12666
    VHS3Q084381EBI-2049096,EBI-30482
    WBP1P337671EBI-2049096,EBI-12658

    Protein-protein interaction databases

    BioGridi33568. 72 interactions.
    DIPiDIP-8755N.
    IntActiP39540. 5 interactions.
    MINTiMINT-1357650.
    STRINGi4932.YJL196C.

    Structurei

    3D structure databases

    ProteinModelPortaliP39540.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6363ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini85 – 10016CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini122 – 18665ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 23427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 27116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31018CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ELO family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305096.
    GeneTreeiENSGT00740000115027.
    HOGENOMiHOG000160635.
    KOiK10245.
    OMAiLLMHICI.
    OrthoDBiEOG7F51CG.

    Family and domain databases

    InterProiIPR002076. GNS1_SUR4.
    [Graphical view]
    PANTHERiPTHR11157. PTHR11157. 1 hit.
    PfamiPF01151. ELO. 1 hit.
    [Graphical view]
    PROSITEiPS01188. ELO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39540-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSDWKNFCL EKASRFRPTI DRPFFNIYLW DYFNRAVGWA TAGRFQPKDF    50
    EFTVGKQPLS EPRPVLLFIA MYYVVIFGGR SLVKSCKPLK LRFISQVHNL 100
    MLTSVSFLWL ILMVEQMLPI VYRHGLYFAV CNVESWTQPM ETLYYLNYMT 150
    KFVEFADTVL MVLKHRKLTF LHTYHHGATA LLCYNQLVGY TAVTWVPVTL 200
    NLAVHVLMYW YYFLSASGIR VWWKAWVTRL QIVQFMLDLI VVYYVLYQKI 250
    VAAYFKNACT PQCEDCLGSM TAIAAGAAIL TSYLFLFISF YIEVYKRGSA 300
    SGKKKINKNN 310
    Length:310
    Mass (Da):36,234
    Last modified:February 1, 1995 - v1
    Checksum:i051D5369976BF48F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77688 Genomic DNA. Translation: CAA54764.1.
    Z49471 Genomic DNA. Translation: CAA89491.1.
    BK006943 Genomic DNA. Translation: DAA08612.1.
    PIRiS46638.
    RefSeqiNP_012339.1. NM_001181629.1.

    Genome annotation databases

    EnsemblFungiiYJL196C; YJL196C; YJL196C.
    GeneIDi853243.
    KEGGisce:YJL196C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77688 Genomic DNA. Translation: CAA54764.1 .
    Z49471 Genomic DNA. Translation: CAA89491.1 .
    BK006943 Genomic DNA. Translation: DAA08612.1 .
    PIRi S46638.
    RefSeqi NP_012339.1. NM_001181629.1.

    3D structure databases

    ProteinModelPortali P39540.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33568. 72 interactions.
    DIPi DIP-8755N.
    IntActi P39540. 5 interactions.
    MINTi MINT-1357650.
    STRINGi 4932.YJL196C.

    Proteomic databases

    MaxQBi P39540.
    PaxDbi P39540.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL196C ; YJL196C ; YJL196C .
    GeneIDi 853243.
    KEGGi sce:YJL196C.

    Organism-specific databases

    CYGDi YJL196c.
    SGDi S000003732. ELO1.

    Phylogenomic databases

    eggNOGi NOG305096.
    GeneTreei ENSGT00740000115027.
    HOGENOMi HOG000160635.
    KOi K10245.
    OMAi LLMHICI.
    OrthoDBi EOG7F51CG.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31627-MONOMER.

    Miscellaneous databases

    NextBioi 973475.
    PROi P39540.

    Gene expression databases

    Genevestigatori P39540.

    Family and domain databases

    InterProi IPR002076. GNS1_SUR4.
    [Graphical view ]
    PANTHERi PTHR11157. PTHR11157. 1 hit.
    Pfami PF01151. ELO. 1 hit.
    [Graphical view ]
    PROSITEi PS01188. ELO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae."
      Toke D.A., Martin C.E.
      J. Biol. Chem. 271:18413-18422(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    2. "The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes."
      Purnelle B., Coster F., Goffeau A.
      Yeast 10:1235-1249(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiELO1_YEAST
    AccessioniPrimary (citable) accession number: P39540
    Secondary accession number(s): D6VVZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 937 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3