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P39540

- ELO1_YEAST

UniProt

P39540 - ELO1_YEAST

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Protein
Elongation of fatty acids protein 1
Gene
ELO1, YJL196C, J0343
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be a membrane bound enzyme involved in the highly specific elongation of saturated 14-carbon fatty acids (14:0) to 16-carbon species (16:0).

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.

GO - Molecular functioni

  1. fatty acid elongase activity Source: SGD

GO - Biological processi

  1. fatty acid elongation, unsaturated fatty acid Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-31627-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation of fatty acids protein 1 (EC:2.3.1.199)
Alternative name(s):
3-keto acyl-CoA synthase ELO1
Very-long-chain 3-oxoacyl-CoA synthase 1
Gene namesi
Name:ELO1
Ordered Locus Names:YJL196C
ORF Names:J0343
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL196c.
SGDiS000003732. ELO1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363Extracellular Reviewed prediction
Add
BLAST
Transmembranei64 – 8421Helical; Reviewed prediction
Add
BLAST
Topological domaini85 – 10016Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Reviewed prediction
Add
BLAST
Topological domaini122 – 18665Extracellular Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST
Topological domaini208 – 23427Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei235 – 25521Helical; Reviewed prediction
Add
BLAST
Topological domaini256 – 27116Extracellular Reviewed prediction
Add
BLAST
Transmembranei272 – 29221Helical; Reviewed prediction
Add
BLAST
Topological domaini293 – 31018Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Elongation of fatty acids protein 1
PRO_0000207548Add
BLAST

Proteomic databases

MaxQBiP39540.
PaxDbiP39540.

Expressioni

Inductioni

Induced in wild-type cells supplemented with 14:0 fatty acids and repressed when cells are supplied with 16- and 18-carbon fatty acids.

Gene expression databases

GenevestigatoriP39540.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CHO1P084561EBI-2049096,EBI-14055
CHO2P053741EBI-2049096,EBI-2049142
DAL5P153651EBI-2049096,EBI-5527
ERG11P106141EBI-2049096,EBI-5127
ERG25P530451EBI-2049096,EBI-6506
ERG5P547811EBI-2049096,EBI-6563
ERP1Q053591EBI-2049096,EBI-6581
ERV25P548371EBI-2049096,EBI-6642
GAP1P191451EBI-2049096,EBI-7314
ORM2Q061441EBI-2049096,EBI-34916
PHO88P382641EBI-2049096,EBI-13350
PIS1P061971EBI-2049096,EBI-13458
SAC1P323681EBI-2049096,EBI-16210
SCS7Q035291EBI-2049096,EBI-16747
SPC1P469651EBI-2049096,EBI-17823
SPC2Q049691EBI-2049096,EBI-27827
SPF1P399861EBI-2049096,EBI-3128
SWP1Q027951EBI-2049096,EBI-12666
VHS3Q084381EBI-2049096,EBI-30482
WBP1P337671EBI-2049096,EBI-12658

Protein-protein interaction databases

BioGridi33568. 72 interactions.
DIPiDIP-8755N.
IntActiP39540. 5 interactions.
MINTiMINT-1357650.
STRINGi4932.YJL196C.

Structurei

3D structure databases

ProteinModelPortaliP39540.

Family & Domainsi

Sequence similaritiesi

Belongs to the ELO family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305096.
GeneTreeiENSGT00740000115027.
HOGENOMiHOG000160635.
KOiK10245.
OMAiLLMHICI.
OrthoDBiEOG7F51CG.

Family and domain databases

InterProiIPR002076. GNS1_SUR4.
[Graphical view]
PANTHERiPTHR11157. PTHR11157. 1 hit.
PfamiPF01151. ELO. 1 hit.
[Graphical view]
PROSITEiPS01188. ELO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39540-1 [UniParc]FASTAAdd to Basket

« Hide

MVSDWKNFCL EKASRFRPTI DRPFFNIYLW DYFNRAVGWA TAGRFQPKDF    50
EFTVGKQPLS EPRPVLLFIA MYYVVIFGGR SLVKSCKPLK LRFISQVHNL 100
MLTSVSFLWL ILMVEQMLPI VYRHGLYFAV CNVESWTQPM ETLYYLNYMT 150
KFVEFADTVL MVLKHRKLTF LHTYHHGATA LLCYNQLVGY TAVTWVPVTL 200
NLAVHVLMYW YYFLSASGIR VWWKAWVTRL QIVQFMLDLI VVYYVLYQKI 250
VAAYFKNACT PQCEDCLGSM TAIAAGAAIL TSYLFLFISF YIEVYKRGSA 300
SGKKKINKNN 310
Length:310
Mass (Da):36,234
Last modified:February 1, 1995 - v1
Checksum:i051D5369976BF48F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77688 Genomic DNA. Translation: CAA54764.1.
Z49471 Genomic DNA. Translation: CAA89491.1.
BK006943 Genomic DNA. Translation: DAA08612.1.
PIRiS46638.
RefSeqiNP_012339.1. NM_001181629.1.

Genome annotation databases

EnsemblFungiiYJL196C; YJL196C; YJL196C.
GeneIDi853243.
KEGGisce:YJL196C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77688 Genomic DNA. Translation: CAA54764.1 .
Z49471 Genomic DNA. Translation: CAA89491.1 .
BK006943 Genomic DNA. Translation: DAA08612.1 .
PIRi S46638.
RefSeqi NP_012339.1. NM_001181629.1.

3D structure databases

ProteinModelPortali P39540.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33568. 72 interactions.
DIPi DIP-8755N.
IntActi P39540. 5 interactions.
MINTi MINT-1357650.
STRINGi 4932.YJL196C.

Proteomic databases

MaxQBi P39540.
PaxDbi P39540.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL196C ; YJL196C ; YJL196C .
GeneIDi 853243.
KEGGi sce:YJL196C.

Organism-specific databases

CYGDi YJL196c.
SGDi S000003732. ELO1.

Phylogenomic databases

eggNOGi NOG305096.
GeneTreei ENSGT00740000115027.
HOGENOMi HOG000160635.
KOi K10245.
OMAi LLMHICI.
OrthoDBi EOG7F51CG.

Enzyme and pathway databases

BioCyci YEAST:G3O-31627-MONOMER.

Miscellaneous databases

NextBioi 973475.
PROi P39540.

Gene expression databases

Genevestigatori P39540.

Family and domain databases

InterProi IPR002076. GNS1_SUR4.
[Graphical view ]
PANTHERi PTHR11157. PTHR11157. 1 hit.
Pfami PF01151. ELO. 1 hit.
[Graphical view ]
PROSITEi PS01188. ELO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae."
    Toke D.A., Martin C.E.
    J. Biol. Chem. 271:18413-18422(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
  2. "The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes."
    Purnelle B., Coster F., Goffeau A.
    Yeast 10:1235-1249(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiELO1_YEAST
AccessioniPrimary (citable) accession number: P39540
Secondary accession number(s): D6VVZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 937 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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