P39535 (PHO90_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 97.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Low-affinity phosphate transporter PHO90 | ||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome] | ||||||
| Taxonomic identifier | 559292 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › ![]() |
Protein attributes
| Sequence length | 881 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Low-affinity phosphate transporter involved in the control of cellular phosphate levels. Ref.4 Ref.7 |
| Subcellular location | Membrane; Multi-pass membrane protein Potential. |
| Induction | Expression is constitutive and independent of inorganic phosphate concentration and PHO4 activity. Ref.5 |
| Miscellaneous | Present with 3430 molecules/cell in log phase SD medium. |
| Sequence similarities | Belongs to the CitM (TC 2.A.11) transporter family. [View classification] Contains 1 SPX domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phosphate transport Transport |
| Cellular component | Membrane |
| Domain | Transmembrane Transmembrane helix |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | sodium ion transport Inferred from electronic annotation. Source: InterPro |
| Cellular_component | integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD |
| Molecular_function | phosphate ion transmembrane transporter activity Inferred from genetic interaction Ref.4. Source: SGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 881 | 881 | Low-affinity phosphate transporter PHO90 | PRO_0000172518 | |||||
Regions | |||||||||
| Transmembrane | 417 – 437 | 21 | Helical; Potential | ||||||
| Transmembrane | 456 – 476 | 21 | Helical; Potential | ||||||
| Transmembrane | 493 – 513 | 21 | Helical; Potential | ||||||
| Transmembrane | 514 – 534 | 21 | Helical; Potential | ||||||
| Transmembrane | 539 – 559 | 21 | Helical; Potential | ||||||
| Transmembrane | 581 – 601 | 21 | Helical; Potential | ||||||
| Transmembrane | 663 – 683 | 21 | Helical; Potential | ||||||
| Transmembrane | 691 – 711 | 21 | Helical; Potential | ||||||
| Transmembrane | 718 – 738 | 21 | Helical; Potential | ||||||
| Transmembrane | 758 – 778 | 21 | Helical; Potential | ||||||
| Transmembrane | 805 – 825 | 21 | Helical; Potential | ||||||
| Transmembrane | 854 – 874 | 21 | Helical; Potential | ||||||
| Domain | 1 – 288 | 288 | SPX | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes." Purnelle B., Coster F., Goffeau A. Yeast 10:1235-1249(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [2] | "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. Karpfinger-Hartl L.EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [3] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [4] | "Phosphate transport and sensing in Saccharomyces cerevisiae." Wykoff D.D., O'Shea E.K. Genetics 159:1491-1499(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. |
| [5] | "Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae." Auesukaree C., Homma T., Kaneko Y., Harashima S. Biochem. Biophys. Res. Commun. 306:843-850(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION. |
| [6] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [7] | "Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor." Popova Y., Thayumanavan P., Lonati E., Agrochao M., Thevelein J.M. Proc. Natl. Acad. Sci. U.S.A. 107:2890-2895(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X77688 Genomic DNA. Translation: CAA54759.1. Z49473 Genomic DNA. Translation: CAA89493.1. BK006943 Genomic DNA. Translation: DAA08610.1. |
| PIR | S46633. |
| RefSeq | NP_012337.1. NM_001181631.1. |
3D structure databases | |
| ProteinModelPortal | P39535. |
| SMR | P39535. Positions 411-871. |
| ModBase | Search... |
Protein-protein interaction databases | |
| MINT | MINT-4491371. |
| STRING | 4932.YJL198W. |
Proteomic databases | |
| PaxDb | P39535. |
| PRIDE | P39535. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YJL198W; YJL198W; YJL198W. |
| GeneID | 853241. |
| KEGG | sce:YJL198W. |
Organism-specific databases | |
| CYGD | YJL198w. |
| SGD | S000003734. PHO90. |
Phylogenomic databases | |
| eggNOG | COG5408. |
| GeneTree | ENSGT00550000074480. |
| KO | K14430. |
| OrthoDB | EOG437VP2. |
Gene expression databases | |
| Genevestigator | P39535. |
| GermOnline | YJL198W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR001898. Na/sul_symport. IPR004331. SPX_N. [Graphical view] |
| Pfam | PF00939. Na_sulph_symp. 1 hit. PF03105. SPX. 1 hit. [Graphical view] |
| PROSITE | PS51382. SPX. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 973469. |
Entry information
| Entry name | PHO90_YEAST | ||||||||
| Accession | Primary (citable) accession number: P39535 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome X Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with
