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P39525

- CEM1_YEAST

UniProt

P39525 - CEM1_YEAST

Protein

3-oxoacyl-[acyl-carrier-protein] synthase homolog

Gene

CEM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Possibly involved in the synthesis of a specialized molecule, probably related to a fatty acid, which is essential for mitochondrial respiration. Is essential for oxygen uptake and the presence of cytochromes A and B.

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei187 – 1871PROSITE-ProRule annotation

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: SGD

    GO - Biological processi

    1. fatty acid biosynthetic process Source: SGD

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciMetaCyc:YER061C-MONOMER.
    YEAST:YER061C-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase homolog (EC:2.3.1.41)
    Alternative name(s):
    Beta-ketoacyl-ACP synthase homolog
    Gene namesi
    Name:CEM1
    Ordered Locus Names:YER061C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    SGDiS000000863. CEM1.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4424423-oxoacyl-[acyl-carrier-protein] synthase homologPRO_0000180356Add
    BLAST

    Proteomic databases

    MaxQBiP39525.
    PaxDbiP39525.
    PeptideAtlasiP39525.

    Expressioni

    Gene expression databases

    GenevestigatoriP39525.

    Interactioni

    Protein-protein interaction databases

    BioGridi36803. 164 interactions.
    DIPiDIP-5342N.
    IntActiP39525. 1 interaction.
    MINTiMINT-515613.
    STRINGi4932.YER061C.

    Structurei

    3D structure databases

    ProteinModelPortaliP39525.
    SMRiP39525. Positions 3-436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG0304.
    GeneTreeiENSGT00530000063309.
    HOGENOMiHOG000060166.
    KOiK09458.
    OMAiHAQKRNA.
    OrthoDBiEOG7T1RN8.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000447. KAS_II. 1 hit.
    SUPFAMiSSF53901. SSF53901. 3 hits.
    PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P39525-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRVVITGL GCVTPLGRSL SESWGNLLSS KNGLTPITSL PNYNEDYKLR    50
    EKSIPSTITV GKIPENFQNE NSAINKLLFT SQDERRTSSF IKLALRTTYE 100
    ALHNAGLLNP NDITINTSLC NLDHFGCLIG SGIGSIQDIY QTSLQFHNDN 150
    KRINPYFVPK ILTNMAAGNV SIKFNLRGLS HSVSTACATG NNSIGDAFNF 200
    IRLGMQDICV AGASETSLHP LSLAGFIRAK SITTNGISRP FDTQRSGFVL 250
    GEGCGMIVME SLEHAQKRNA NIISELVGYG LSSDACHITS PPADGNGAKR 300
    AIEMALKMAR LEPTDVDYVN AHATSTLLGD KAECLAVASA LLPGRSKSKP 350
    LYISSNKGAI GHLLGAAGAV ESIFTICSLK DDKMPHTLNL DNVLTLENNE 400
    ADKLHFIRDK PIVGANPKYA LCNSFGFGGV NTSLLFKKWE GS 442
    Length:442
    Mass (Da):47,555
    Last modified:February 1, 1995 - v1
    Checksum:iDAF2FF358A7AA067
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73488 Genomic DNA. Translation: CAB58180.1.
    U18813 Genomic DNA. Translation: AAB64597.1.
    BK006939 Genomic DNA. Translation: DAA07720.2.
    PIRiS36204.
    RefSeqiNP_010983.2. NM_001178952.2.

    Genome annotation databases

    EnsemblFungiiYER061C; YER061C; YER061C.
    GeneIDi856790.
    KEGGisce:YER061C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73488 Genomic DNA. Translation: CAB58180.1 .
    U18813 Genomic DNA. Translation: AAB64597.1 .
    BK006939 Genomic DNA. Translation: DAA07720.2 .
    PIRi S36204.
    RefSeqi NP_010983.2. NM_001178952.2.

    3D structure databases

    ProteinModelPortali P39525.
    SMRi P39525. Positions 3-436.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36803. 164 interactions.
    DIPi DIP-5342N.
    IntActi P39525. 1 interaction.
    MINTi MINT-515613.
    STRINGi 4932.YER061C.

    Proteomic databases

    MaxQBi P39525.
    PaxDbi P39525.
    PeptideAtlasi P39525.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER061C ; YER061C ; YER061C .
    GeneIDi 856790.
    KEGGi sce:YER061C.

    Organism-specific databases

    SGDi S000000863. CEM1.

    Phylogenomic databases

    eggNOGi COG0304.
    GeneTreei ENSGT00530000063309.
    HOGENOMi HOG000060166.
    KOi K09458.
    OMAi HAQKRNA.
    OrthoDBi EOG7T1RN8.

    Enzyme and pathway databases

    BioCyci MetaCyc:YER061C-MONOMER.
    YEAST:YER061C-MONOMER.

    Miscellaneous databases

    NextBioi 983018.
    PROi P39525.

    Gene expression databases

    Genevestigatori P39525.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000447. KAS_II. 1 hit.
    SUPFAMi SSF53901. SSF53901. 3 hits.
    PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a new nuclear gene (CEM1) encoding a protein homologous to a beta-keto-acyl synthase which is essential for mitochondrial respiration in Saccharomyces cerevisiae."
      Harington A., Herbert C.J., Tung B., Getz G.S., Slonimski P.P.
      Mol. Microbiol. 9:545-555(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CW04.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCEM1_YEAST
    AccessioniPrimary (citable) accession number: P39525
    Secondary accession number(s): D3DLW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1660 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3