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Protein

3-oxoacyl-[acyl-carrier-protein] synthase homolog

Gene

CEM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possibly involved in the synthesis of a specialized molecule, probably related to a fatty acid, which is essential for mitochondrial respiration. Is essential for oxygen uptake and the presence of cytochromes A and B.

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei187 – 1871PROSITE-ProRule annotation

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: SGD

GO - Biological processi

  1. fatty acid biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YER061C-MONOMER.
YEAST:YER061C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase homolog (EC:2.3.1.41)
Alternative name(s):
Beta-ketoacyl-ACP synthase homolog
Gene namesi
Name:CEM1
Ordered Locus Names:YER061C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER061C.
SGDiS000000863. CEM1.

Subcellular locationi

  1. Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4424423-oxoacyl-[acyl-carrier-protein] synthase homologPRO_0000180356Add
BLAST

Proteomic databases

MaxQBiP39525.
PaxDbiP39525.
PeptideAtlasiP39525.

Expressioni

Gene expression databases

GenevestigatoriP39525.

Interactioni

Protein-protein interaction databases

BioGridi36803. 164 interactions.
DIPiDIP-5342N.
IntActiP39525. 1 interaction.
MINTiMINT-515613.
STRINGi4932.YER061C.

Structurei

3D structure databases

ProteinModelPortaliP39525.
SMRiP39525. Positions 3-436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiCOG0304.
GeneTreeiENSGT00530000063309.
HOGENOMiHOG000060166.
InParanoidiP39525.
KOiK09458.
OMAiMEIAIAQ.
OrthoDBiEOG7T1RN8.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 3 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRVVITGL GCVTPLGRSL SESWGNLLSS KNGLTPITSL PNYNEDYKLR
60 70 80 90 100
EKSIPSTITV GKIPENFQNE NSAINKLLFT SQDERRTSSF IKLALRTTYE
110 120 130 140 150
ALHNAGLLNP NDITINTSLC NLDHFGCLIG SGIGSIQDIY QTSLQFHNDN
160 170 180 190 200
KRINPYFVPK ILTNMAAGNV SIKFNLRGLS HSVSTACATG NNSIGDAFNF
210 220 230 240 250
IRLGMQDICV AGASETSLHP LSLAGFIRAK SITTNGISRP FDTQRSGFVL
260 270 280 290 300
GEGCGMIVME SLEHAQKRNA NIISELVGYG LSSDACHITS PPADGNGAKR
310 320 330 340 350
AIEMALKMAR LEPTDVDYVN AHATSTLLGD KAECLAVASA LLPGRSKSKP
360 370 380 390 400
LYISSNKGAI GHLLGAAGAV ESIFTICSLK DDKMPHTLNL DNVLTLENNE
410 420 430 440
ADKLHFIRDK PIVGANPKYA LCNSFGFGGV NTSLLFKKWE GS
Length:442
Mass (Da):47,555
Last modified:February 1, 1995 - v1
Checksum:iDAF2FF358A7AA067
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73488 Genomic DNA. Translation: CAB58180.1.
U18813 Genomic DNA. Translation: AAB64597.1.
BK006939 Genomic DNA. Translation: DAA07720.2.
PIRiS36204.
RefSeqiNP_010983.2. NM_001178952.2.

Genome annotation databases

EnsemblFungiiYER061C; YER061C; YER061C.
GeneIDi856790.
KEGGisce:YER061C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73488 Genomic DNA. Translation: CAB58180.1.
U18813 Genomic DNA. Translation: AAB64597.1.
BK006939 Genomic DNA. Translation: DAA07720.2.
PIRiS36204.
RefSeqiNP_010983.2. NM_001178952.2.

3D structure databases

ProteinModelPortaliP39525.
SMRiP39525. Positions 3-436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36803. 164 interactions.
DIPiDIP-5342N.
IntActiP39525. 1 interaction.
MINTiMINT-515613.
STRINGi4932.YER061C.

Proteomic databases

MaxQBiP39525.
PaxDbiP39525.
PeptideAtlasiP39525.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER061C; YER061C; YER061C.
GeneIDi856790.
KEGGisce:YER061C.

Organism-specific databases

EuPathDBiFungiDB:YER061C.
SGDiS000000863. CEM1.

Phylogenomic databases

eggNOGiCOG0304.
GeneTreeiENSGT00530000063309.
HOGENOMiHOG000060166.
InParanoidiP39525.
KOiK09458.
OMAiMEIAIAQ.
OrthoDBiEOG7T1RN8.

Enzyme and pathway databases

BioCyciMetaCyc:YER061C-MONOMER.
YEAST:YER061C-MONOMER.

Miscellaneous databases

NextBioi983018.
PROiP39525.

Gene expression databases

GenevestigatoriP39525.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 3 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new nuclear gene (CEM1) encoding a protein homologous to a beta-keto-acyl synthase which is essential for mitochondrial respiration in Saccharomyces cerevisiae."
    Harington A., Herbert C.J., Tung B., Getz G.S., Slonimski P.P.
    Mol. Microbiol. 9:545-555(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CW04.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCEM1_YEAST
AccessioniPrimary (citable) accession number: P39525
Secondary accession number(s): D3DLW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 29, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.