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Protein

3-oxoacyl-[acyl-carrier-protein] synthase homolog

Gene

CEM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possibly involved in the synthesis of a specialized molecule, probably related to a fatty acid, which is essential for mitochondrial respiration. Is essential for oxygen uptake and the presence of cytochromes A and B.

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei187PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YER061C-MONOMER
YEAST:YER061C-MONOMER
ReactomeiR-SCE-163765 ChREBP activates metabolic gene expression
R-SCE-75105 Fatty acyl-CoA biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase homolog (EC:2.3.1.41)
Alternative name(s):
Beta-ketoacyl-ACP synthase homolog
Gene namesi
Name:CEM1
Ordered Locus Names:YER061C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER061C
SGDiS000000863 CEM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001803561 – 4423-oxoacyl-[acyl-carrier-protein] synthase homologAdd BLAST442

Proteomic databases

MaxQBiP39525
PaxDbiP39525
PRIDEiP39525

Interactioni

Protein-protein interaction databases

BioGridi36803, 445 interactors
DIPiDIP-5342N
IntActiP39525, 2 interactors
MINTiP39525
STRINGi4932.YER061C

Structurei

3D structure databases

ProteinModelPortaliP39525
SMRiP39525
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000063309
HOGENOMiHOG000060166
InParanoidiP39525
KOiK09458
OMAiPFFVPKI
OrthoDBiEOG092C32MV

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
SMARTiView protein in SMART
SM00825 PKS_KS, 1 hit
SUPFAMiSSF53901 SSF53901, 3 hits
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

P39525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRVVITGL GCVTPLGRSL SESWGNLLSS KNGLTPITSL PNYNEDYKLR
60 70 80 90 100
EKSIPSTITV GKIPENFQNE NSAINKLLFT SQDERRTSSF IKLALRTTYE
110 120 130 140 150
ALHNAGLLNP NDITINTSLC NLDHFGCLIG SGIGSIQDIY QTSLQFHNDN
160 170 180 190 200
KRINPYFVPK ILTNMAAGNV SIKFNLRGLS HSVSTACATG NNSIGDAFNF
210 220 230 240 250
IRLGMQDICV AGASETSLHP LSLAGFIRAK SITTNGISRP FDTQRSGFVL
260 270 280 290 300
GEGCGMIVME SLEHAQKRNA NIISELVGYG LSSDACHITS PPADGNGAKR
310 320 330 340 350
AIEMALKMAR LEPTDVDYVN AHATSTLLGD KAECLAVASA LLPGRSKSKP
360 370 380 390 400
LYISSNKGAI GHLLGAAGAV ESIFTICSLK DDKMPHTLNL DNVLTLENNE
410 420 430 440
ADKLHFIRDK PIVGANPKYA LCNSFGFGGV NTSLLFKKWE GS
Length:442
Mass (Da):47,555
Last modified:February 1, 1995 - v1
Checksum:iDAF2FF358A7AA067
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73488 Genomic DNA Translation: CAB58180.1
U18813 Genomic DNA Translation: AAB64597.1
BK006939 Genomic DNA Translation: DAA07720.2
PIRiS36204
RefSeqiNP_010983.2, NM_001178952.2

Genome annotation databases

EnsemblFungiiYER061C; YER061C; YER061C
GeneIDi856790
KEGGisce:YER061C

Similar proteinsi

Entry informationi

Entry nameiCEM1_YEAST
AccessioniPrimary (citable) accession number: P39525
Secondary accession number(s): D3DLW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health