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P39525 (CEM1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase homolog

EC=2.3.1.41
Alternative name(s):
Beta-ketoacyl-ACP synthase homolog
Gene names
Name:CEM1
Ordered Locus Names:YER061C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possibly involved in the synthesis of a specialized molecule, probably related to a fatty acid, which is essential for mitochondrial respiration. Is essential for oxygen uptake and the presence of cytochromes A and B.

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Subcellular location

Mitochondrion Ref.4.

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4424423-oxoacyl-[acyl-carrier-protein] synthase homolog
PRO_0000180356

Sites

Active site1871 By similarity

Sequences

Sequence LengthMass (Da)Tools
P39525 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: DAF2FF358A7AA067

FASTA44247,555
        10         20         30         40         50         60 
MSRRVVITGL GCVTPLGRSL SESWGNLLSS KNGLTPITSL PNYNEDYKLR EKSIPSTITV 

        70         80         90        100        110        120 
GKIPENFQNE NSAINKLLFT SQDERRTSSF IKLALRTTYE ALHNAGLLNP NDITINTSLC 

       130        140        150        160        170        180 
NLDHFGCLIG SGIGSIQDIY QTSLQFHNDN KRINPYFVPK ILTNMAAGNV SIKFNLRGLS 

       190        200        210        220        230        240 
HSVSTACATG NNSIGDAFNF IRLGMQDICV AGASETSLHP LSLAGFIRAK SITTNGISRP 

       250        260        270        280        290        300 
FDTQRSGFVL GEGCGMIVME SLEHAQKRNA NIISELVGYG LSSDACHITS PPADGNGAKR 

       310        320        330        340        350        360 
AIEMALKMAR LEPTDVDYVN AHATSTLLGD KAECLAVASA LLPGRSKSKP LYISSNKGAI 

       370        380        390        400        410        420 
GHLLGAAGAV ESIFTICSLK DDKMPHTLNL DNVLTLENNE ADKLHFIRDK PIVGANPKYA 

       430        440 
LCNSFGFGGV NTSLLFKKWE GS 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a new nuclear gene (CEM1) encoding a protein homologous to a beta-keto-acyl synthase which is essential for mitochondrial respiration in Saccharomyces cerevisiae."
Harington A., Herbert C.J., Tung B., Getz G.S., Slonimski P.P.
Mol. Microbiol. 9:545-555(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CW04.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X73488 Genomic DNA. Translation: CAB58180.1.
U18813 Genomic DNA. Translation: AAB64597.1.
BK006939 Genomic DNA. Translation: DAA07720.2.
PIRS36204.
RefSeqNP_010983.2. NM_001178952.2.

3D structure databases

ProteinModelPortalP39525.
SMRP39525. Positions 3-436.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36803. 164 interactions.
DIPDIP-5342N.
IntActP39525. 1 interaction.
MINTMINT-515613.
STRING4932.YER061C.

Proteomic databases

PaxDbP39525.
PeptideAtlasP39525.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER061C; YER061C; YER061C.
GeneID856790.
KEGGsce:YER061C.

Organism-specific databases

SGDS000000863. CEM1.

Phylogenomic databases

eggNOGCOG0304.
GeneTreeENSGT00530000063309.
HOGENOMHOG000060166.
KOK09458.
OMAWMEPKEQ.
OrthoDBEOG7T1RN8.

Enzyme and pathway databases

BioCycMetaCyc:YER061C-MONOMER.
YEAST:YER061C-MONOMER.

Gene expression databases

GenevestigatorP39525.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PIRSFPIRSF000447. KAS_II. 1 hit.
SUPFAMSSF53901. SSF53901. 3 hits.
PROSITEPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio983018.
PROP39525.

Entry information

Entry nameCEM1_YEAST
AccessionPrimary (citable) accession number: P39525
Secondary accession number(s): D3DLW6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families