Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pre-rRNA-processing protein FHL1

Gene

FHL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls the pre-rRNA processing machinery in conjunction with IFH1. Presumably acts as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator.

Miscellaneous

Present with 639 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi460 – 552Fork-headPROSITE-ProRule annotationAdd BLAST93

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34244-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-rRNA-processing protein FHL1
Gene namesi
Name:FHL1
Ordered Locus Names:YPR104C
ORF Names:P8283.15
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR104C
SGDiS000006308 FHL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000919011 – 936Pre-rRNA-processing protein FHL1Add BLAST936

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei230PhosphothreonineCombined sources1
Modified residuei247PhosphothreonineCombined sources1
Modified residuei264PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39521
PaxDbiP39521
PRIDEiP39521

PTM databases

CarbonylDBiP39521
iPTMnetiP39521

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CKB2P389302EBI-6897,EBI-9578

GO - Molecular functioni

  • RNA polymerase II transcription coactivator binding Source: SGD
  • RNA polymerase II transcription corepressor binding Source: SGD

Protein-protein interaction databases

BioGridi36270, 205 interactors
DIPiDIP-3821N
IntActiP39521, 11 interactors
MINTiP39521
STRINGi4932.YPR104C

Structurei

3D structure databases

ProteinModelPortaliP39521
SMRiP39521
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 357FHAPROSITE-ProRule annotationAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi816 – 862Ser-richAdd BLAST47

Phylogenomic databases

GeneTreeiENSGT00910000144055
HOGENOMiHOG000000999
InParanoidiP39521
OMAiICEWIAN
OrthoDBiEOG092C5SQY

Family and domain databases

CDDicd00059 FH, 1 hit
cd00060 FHA, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR001766 Fork_head_dom
IPR008984 SMAD_FHA_dom_sf
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SM00240 FHA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

P39521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGEMAIIES SNHVGTSSPT TETQFTIDSS ALKDQETKES ITNSPTSEVP
60 70 80 90 100
IETKLPKSSD IVTEEKHPQN TTTDIENEVE NPVTDDNGNL KLELPDNLDN
110 120 130 140 150
ADFSKLLEFD AKNDEALFNS NELLSHTMDP VNNIDLTHDH SREVSSKEDI
160 170 180 190 200
NIEPVNPDED EREKTQDNTA AVKTEGIRNS EDTSIQKDEP TADAIYTDVH
210 220 230 240 250
KLSVNKDTET LPTLVDEKNN MLHMRNNSIT PIMFQQHELV GQPPQNTVTE
260 270 280 290 300
NNSTDAETTQ RKLSEPIDAS LPLPNEQPTI FAYARLDFQS FTFYVQTLHA
310 320 330 340 350
IIGRRSENDF SHKVDVNLGP SKSISRRHAQ IFYNFGTGRF ELSIIGKNGA
360 370 380 390 400
FVDDIFVEKG NTVPLRNKTK IQIGQIPFQF ILPEQERNDD SKSPENADIA
410 420 430 440 450
ESEINTRNLK KNEPKSKKKI TTGAKPKKAQ TKPAVKKEKK PPKIPKKVYT
460 470 480 490 500
LEEIPVEYRT KPTVSYSAML TTCIRKYSTA KGMSLSEIYA GIRELFPYYK
510 520 530 540 550
YCPDGWQSSV RHNLSLNKSF RKVSKEGKGW LWGLDEEYIA ERERQKKKQS
560 570 580 590 600
EIAVAKAQAA QLKLEQQQHK LQQVPQRGKK DIVSQRSNVN ARKQNISQTL
610 620 630 640 650
AANRAASNRK NTASDNQRTM KYLQEQLVIL TRDRKGLSKQ VIAAILTQAL
660 670 680 690 700
AMTINQVTQA AKNKGITGNP LTALMDKNPQ HLNLILAAAV NAATAKVTKG
710 720 730 740 750
EVKQLVNPET TAAAALAAKA QHSKPIRQPI VQTPHVPDRP PSQLSASASS
760 770 780 790 800
HPNNYLHDKQ PGSFDPSSLS RFFQPRQNAR ATSSVAATSV PAAASQNVDA
810 820 830 840 850
QPKPKPAQDN DLESESGTSS SSSSSSESGS ESDSGSDDGS ASGSGDNSST
860 870 880 890 900
SSESESESDS GSEVDEKNNK NEKIDSESIK NNESKDDIPS KDENSSNDNR
910 920 930
EISKTDEEGH DSKRRKVSED INEGITEVNV SLEEKL
Length:936
Mass (Da):103,502
Last modified:February 1, 1995 - v1
Checksum:i2FC02DFC0DFFF503
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28348 Genomic DNA Translation: CAA82202.1
U32445 Genomic DNA Translation: AAB68074.1
BK006949 Genomic DNA Translation: DAA11518.1
PIRiS43738
RefSeqiNP_015429.1, NM_001184201.1

Genome annotation databases

EnsemblFungiiYPR104C; YPR104C; YPR104C
GeneIDi856219
KEGGisce:YPR104C

Similar proteinsi

Entry informationi

Entry nameiFHL1_YEAST
AccessioniPrimary (citable) accession number: P39521
Secondary accession number(s): D6W4A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health