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P39521

- FHL1_YEAST

UniProt

P39521 - FHL1_YEAST

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Protein
Pre-rRNA-processing protein FHL1
Gene
FHL1, YPR104C, P8283.15
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Controls the pre-rRNA processing machinery in conjunction with IFH1. Presumably acts as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi460 – 55293Fork-head
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II transcription coactivator binding Source: SGD
  2. RNA polymerase II transcription corepressor binding Source: SGD
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter Source: SGD
  2. positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter Source: SGD
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34244-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-rRNA-processing protein FHL1
Gene namesi
Name:FHL1
Ordered Locus Names:YPR104C
ORF Names:P8283.15
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR104c.
SGDiS000006308. FHL1.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nuclear chromatin Source: SGD
  2. nucleolus Source: SGD
  3. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 936936Pre-rRNA-processing protein FHL1
PRO_0000091901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441Phosphoserine2 Publications
Modified residuei228 – 2281Phosphoserine1 Publication
Modified residuei230 – 2301Phosphothreonine1 Publication
Modified residuei247 – 2471Phosphothreonine1 Publication
Modified residuei264 – 2641Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39521.
PaxDbiP39521.
PeptideAtlasiP39521.

Expressioni

Gene expression databases

GenevestigatoriP39521.

Interactioni

Protein-protein interaction databases

BioGridi36270. 42 interactions.
DIPiDIP-3821N.
IntActiP39521. 1 interaction.
MINTiMINT-495767.
STRINGi4932.YPR104C.

Structurei

3D structure databases

ProteinModelPortaliP39521.
SMRiP39521. Positions 292-385, 461-534.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini300 – 35758FHA
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi816 – 86247Ser-rich
Add
BLAST

Sequence similaritiesi

Contains 1 FHA domain.

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00750000117242.
HOGENOMiHOG000000999.
OrthoDBiEOG7J70RS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39521-1 [UniParc]FASTAAdd to Basket

« Hide

MDGEMAIIES SNHVGTSSPT TETQFTIDSS ALKDQETKES ITNSPTSEVP    50
IETKLPKSSD IVTEEKHPQN TTTDIENEVE NPVTDDNGNL KLELPDNLDN 100
ADFSKLLEFD AKNDEALFNS NELLSHTMDP VNNIDLTHDH SREVSSKEDI 150
NIEPVNPDED EREKTQDNTA AVKTEGIRNS EDTSIQKDEP TADAIYTDVH 200
KLSVNKDTET LPTLVDEKNN MLHMRNNSIT PIMFQQHELV GQPPQNTVTE 250
NNSTDAETTQ RKLSEPIDAS LPLPNEQPTI FAYARLDFQS FTFYVQTLHA 300
IIGRRSENDF SHKVDVNLGP SKSISRRHAQ IFYNFGTGRF ELSIIGKNGA 350
FVDDIFVEKG NTVPLRNKTK IQIGQIPFQF ILPEQERNDD SKSPENADIA 400
ESEINTRNLK KNEPKSKKKI TTGAKPKKAQ TKPAVKKEKK PPKIPKKVYT 450
LEEIPVEYRT KPTVSYSAML TTCIRKYSTA KGMSLSEIYA GIRELFPYYK 500
YCPDGWQSSV RHNLSLNKSF RKVSKEGKGW LWGLDEEYIA ERERQKKKQS 550
EIAVAKAQAA QLKLEQQQHK LQQVPQRGKK DIVSQRSNVN ARKQNISQTL 600
AANRAASNRK NTASDNQRTM KYLQEQLVIL TRDRKGLSKQ VIAAILTQAL 650
AMTINQVTQA AKNKGITGNP LTALMDKNPQ HLNLILAAAV NAATAKVTKG 700
EVKQLVNPET TAAAALAAKA QHSKPIRQPI VQTPHVPDRP PSQLSASASS 750
HPNNYLHDKQ PGSFDPSSLS RFFQPRQNAR ATSSVAATSV PAAASQNVDA 800
QPKPKPAQDN DLESESGTSS SSSSSSESGS ESDSGSDDGS ASGSGDNSST 850
SSESESESDS GSEVDEKNNK NEKIDSESIK NNESKDDIPS KDENSSNDNR 900
EISKTDEEGH DSKRRKVSED INEGITEVNV SLEEKL 936
Length:936
Mass (Da):103,502
Last modified:February 1, 1995 - v1
Checksum:i2FC02DFC0DFFF503
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28348 Genomic DNA. Translation: CAA82202.1.
U32445 Genomic DNA. Translation: AAB68074.1.
BK006949 Genomic DNA. Translation: DAA11518.1.
PIRiS43738.
RefSeqiNP_015429.1. NM_001184201.1.

Genome annotation databases

EnsemblFungiiYPR104C; YPR104C; YPR104C.
GeneIDi856219.
KEGGisce:YPR104C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28348 Genomic DNA. Translation: CAA82202.1 .
U32445 Genomic DNA. Translation: AAB68074.1 .
BK006949 Genomic DNA. Translation: DAA11518.1 .
PIRi S43738.
RefSeqi NP_015429.1. NM_001184201.1.

3D structure databases

ProteinModelPortali P39521.
SMRi P39521. Positions 292-385, 461-534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36270. 42 interactions.
DIPi DIP-3821N.
IntActi P39521. 1 interaction.
MINTi MINT-495767.
STRINGi 4932.YPR104C.

Proteomic databases

MaxQBi P39521.
PaxDbi P39521.
PeptideAtlasi P39521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR104C ; YPR104C ; YPR104C .
GeneIDi 856219.
KEGGi sce:YPR104C.

Organism-specific databases

CYGDi YPR104c.
SGDi S000006308. FHL1.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00750000117242.
HOGENOMi HOG000000999.
OrthoDBi EOG7J70RS.

Enzyme and pathway databases

BioCyci YEAST:G3O-34244-MONOMER.

Miscellaneous databases

NextBioi 981444.

Gene expression databases

Genevestigatori P39521.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.200.20. 1 hit.
InterProi IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00498. FHA. 1 hit.
PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
SM00240. FHA. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
PROSITEi PS50006. FHA_DOMAIN. 1 hit.
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Suppression of yeast RNA polymerase III mutations by FHL1, a gene coding for a fork head protein involved in rRNA processing."
    Hermann-Ledenmat S., Werner M., Sentenac A., Thuriaux P.
    Mol. Cell. Biol. 14:2905-2913(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 28383 / FL100 / VTT C-80102.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-228; THR-230; THR-247 AND SER-264, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFHL1_YEAST
AccessioniPrimary (citable) accession number: P39521
Secondary accession number(s): D6W4A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 639 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

Similar proteinsi