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Protein

Mitochondrial import inner membrane translocase subunit TIM17

Gene

TIM17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.1 Publication

Miscellaneous

Present with 1210 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • mitochondrial genome maintenance Source: SGD
  • protein import into mitochondrial matrix Source: SGD

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31587-MONOMER

Protein family/group databases

TCDBi3.A.8.1.1 the mitochondrial protein translocase (mpt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM17
Alternative name(s):
Mitochondrial inner membrane protein MIM17
Mitochondrial protein import protein 2
Gene namesi
Name:TIM17
Synonyms:MIM17, MPI2, SMS1
Ordered Locus Names:YJL143W
ORF Names:J0648
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL143W
SGDiS000003679 TIM17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11Mitochondrial intermembrane1 PublicationAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 58Mitochondrial matrixSequence analysisAdd BLAST26
Transmembranei59 – 75HelicalSequence analysisAdd BLAST17
Topological domaini76 – 87Mitochondrial intermembrane1 PublicationAdd BLAST12
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 112Mitochondrial matrixSequence analysis4
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 158Mitochondrial intermembraneSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4D → R: Induces abolition of mitochondrial import of transit peptide-containing proteins; when associated with K-8. 1 Publication1
Mutagenesisi8D → K: Induces abolition of mitochondrial import of transit peptide-containing proteins; when associated with K-4. 1 Publication1
Mutagenesisi10C → S: Abolishes disulfide bond, leading to destabilization of the TIM23 complex. 1 Publication1
Mutagenesisi77C → S: Abolishes disulfide bond, leading to destabilization of the TIM23 complex. 1 Publication1
Mutagenesisi118C → S: Does not affect oxidation state. 1 Publication1
Mutagenesisi120C → S: Does not affect oxidation state. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102961 – 158Mitochondrial import inner membrane translocase subunit TIM17Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi10 ↔ 771 Publication

Post-translational modificationi

The disulfide bond is required for stabilization of the TIM23 complex.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP39515
PaxDbiP39515
PRIDEiP39515

Interactioni

Subunit structurei

Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21 (PubMed:15797382, PubMed:27265872). The complex interacts with the TIM44 component of the PAM complex (PubMed:15797382).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33615, 36 interactors
DIPiDIP-2108N
IntActiP39515, 11 interactors
MINTiP39515
STRINGi4932.YJL143W

Structurei

3D structure databases

ProteinModelPortaliP39515
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017780
HOGENOMiHOG000183190
InParanoidiP39515
KOiK17795
OMAiPIIAGNF
OrthoDBiEOG092C5C6F

Family and domain databases

InterProiView protein in InterPro
IPR005678 Tim17
TIGRFAMsiTIGR00980 3a0801so1tim17, 1 hit

Sequencei

Sequence statusi: Complete.

P39515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADHSRDPC PIVILNDFGG AFAMGAIGGV VWHGIKGFRN SPLGERGSGA
60 70 80 90 100
MSAIKARAPV LGGNFGVWGG LFSTFDCAVK AVRKREDPWN AIIAGFFTGG
110 120 130 140 150
ALAVRGGWRH TRNSSITCAC LLGVIEGVGL MFQRYAAWQA KPMAPPLPEA

PSSQPLQA
Length:158
Mass (Da):16,584
Last modified:February 1, 1995 - v1
Checksum:i1760B08F3B60D378
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33H → T in AAB32164 (PubMed:7919535).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77796 Genomic DNA Translation: CAA54823.1
S74018 Genomic DNA Translation: AAB32164.1
X87371 Genomic DNA Translation: CAA60812.1
Z49418 Genomic DNA Translation: CAA89438.1
AY557852 Genomic DNA Translation: AAS56178.1
BK006943 Genomic DNA Translation: DAA08658.1
PIRiS46257
RefSeqiNP_012392.1, NM_001181576.1

Genome annotation databases

EnsemblFungiiYJL143W; YJL143W; YJL143W
GeneIDi853298
KEGGisce:YJL143W

Similar proteinsi

Entry informationi

Entry nameiTIM17_YEAST
AccessioniPrimary (citable) accession number: P39515
Secondary accession number(s): D6VW42, Q02310
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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