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Protein

Mitochondrial import inner membrane translocase subunit TIM17

Gene

TIM17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial genome maintenance Source: SGD
  • protein import into mitochondrial matrix Source: SGD
  • protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31587-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Protein family/group databases

TCDBi3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM17
Alternative name(s):
Mitochondrial inner membrane protein MIM17
Mitochondrial protein import protein 2
Gene namesi
Name:TIM17
Synonyms:MIM17, MPI2, SMS1
Ordered Locus Names:YJL143W
ORF Names:J0648
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL143W.
SGDiS000003679. TIM17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11Mitochondrial intermembraneSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 58Mitochondrial matrixSequence analysisAdd BLAST26
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 87Mitochondrial intermembraneSequence analysis8
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 112Mitochondrial matrixSequence analysis4
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 158Mitochondrial intermembraneSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4D → R: Induces abolition of mitochondrial import of transit peptide-containing proteins; when associated with K-8. 1 Publication1
Mutagenesisi8D → K: Induces abolition of mitochondrial import of transit peptide-containing proteins; when associated with K-4. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102961 – 158Mitochondrial import inner membrane translocase subunit TIM17Add BLAST158

Proteomic databases

MaxQBiP39515.
PRIDEiP39515.

Interactioni

Subunit structurei

Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. The complex interacts with the TIM44 component of the PAM complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PAM16P429494EBI-9127,EBI-26019
PAM18Q079143EBI-9127,EBI-31963
TIM23P3289713EBI-9127,EBI-9136
TIM44Q018522EBI-9127,EBI-9141

Protein-protein interaction databases

BioGridi33615. 28 interactors.
DIPiDIP-2108N.
IntActiP39515. 11 interactors.
MINTiMINT-510240.

Structurei

3D structure databases

ProteinModelPortaliP39515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017780.
HOGENOMiHOG000183190.
InParanoidiP39515.
KOiK17795.
OMAiWKHTRNS.
OrthoDBiEOG092C5C6F.

Family and domain databases

InterProiIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PANTHERiPTHR10485. PTHR10485. 1 hit.
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.

Sequencei

Sequence statusi: Complete.

P39515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADHSRDPC PIVILNDFGG AFAMGAIGGV VWHGIKGFRN SPLGERGSGA
60 70 80 90 100
MSAIKARAPV LGGNFGVWGG LFSTFDCAVK AVRKREDPWN AIIAGFFTGG
110 120 130 140 150
ALAVRGGWRH TRNSSITCAC LLGVIEGVGL MFQRYAAWQA KPMAPPLPEA

PSSQPLQA
Length:158
Mass (Da):16,584
Last modified:February 1, 1995 - v1
Checksum:i1760B08F3B60D378
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33H → T in AAB32164 (PubMed:7919535).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77796 Genomic DNA. Translation: CAA54823.1.
S74018 Genomic DNA. Translation: AAB32164.1.
X87371 Genomic DNA. Translation: CAA60812.1.
Z49418 Genomic DNA. Translation: CAA89438.1.
AY557852 Genomic DNA. Translation: AAS56178.1.
BK006943 Genomic DNA. Translation: DAA08658.1.
PIRiS46257.
RefSeqiNP_012392.1. NM_001181576.1.

Genome annotation databases

EnsemblFungiiYJL143W; YJL143W; YJL143W.
GeneIDi853298.
KEGGisce:YJL143W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77796 Genomic DNA. Translation: CAA54823.1.
S74018 Genomic DNA. Translation: AAB32164.1.
X87371 Genomic DNA. Translation: CAA60812.1.
Z49418 Genomic DNA. Translation: CAA89438.1.
AY557852 Genomic DNA. Translation: AAS56178.1.
BK006943 Genomic DNA. Translation: DAA08658.1.
PIRiS46257.
RefSeqiNP_012392.1. NM_001181576.1.

3D structure databases

ProteinModelPortaliP39515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33615. 28 interactors.
DIPiDIP-2108N.
IntActiP39515. 11 interactors.
MINTiMINT-510240.

Protein family/group databases

TCDBi3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Proteomic databases

MaxQBiP39515.
PRIDEiP39515.

Protocols and materials databases

DNASUi853298.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL143W; YJL143W; YJL143W.
GeneIDi853298.
KEGGisce:YJL143W.

Organism-specific databases

EuPathDBiFungiDB:YJL143W.
SGDiS000003679. TIM17.

Phylogenomic databases

GeneTreeiENSGT00390000017780.
HOGENOMiHOG000183190.
InParanoidiP39515.
KOiK17795.
OMAiWKHTRNS.
OrthoDBiEOG092C5C6F.

Enzyme and pathway databases

BioCyciYEAST:G3O-31587-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Miscellaneous databases

PROiP39515.

Family and domain databases

InterProiIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PANTHERiPTHR10485. PTHR10485. 1 hit.
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTIM17_YEAST
AccessioniPrimary (citable) accession number: P39515
Secondary accession number(s): D6VW42, Q02310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1210 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.