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Protein

Anti-restriction endonuclease

Gene

arn

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Pays a role in the inhibition of the host restriction-modification system. Strongly inhibits the host mcrA endonuclease that cleaves 5-methyl and 5-hydroxymethylcytosines at the specific DNA sequence C(me)CGG.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processHost-virus interaction, Restriction-modification system evasion by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-restriction endonuclease
Alternative name(s):
Anti-rgl nuclease
Gene namesi
Name:arn
Synonyms:asiA.1, motA.-6
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001649181 – 92Anti-restriction endonucleaseAdd BLAST92

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 14Combined sources4
Helixi16 – 24Combined sources9
Helixi26 – 43Combined sources18
Beta strandi45 – 51Combined sources7
Helixi55 – 57Combined sources3
Beta strandi60 – 65Combined sources6
Helixi71 – 84Combined sources14
Helixi88 – 91Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WX4X-ray1.90A1-92[»]
SMRiP39510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

OrthoDBiVOG090001N5.

Sequencei

Sequence statusi: Complete.

P39510-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIDSQSVVQ YTFKIDILEK LYKFLPNLYH SIVNELVEEL HLENNDFLIG
60 70 80 90
TYKDLSKAGY FYVIPAPGKN IDDVLKTIMI YVHDYEIEDY FE
Length:92
Mass (Da):10,900
Last modified:February 1, 1995 - v1
Checksum:i6CFE8EB1711C657D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37801 Genomic DNA. Translation: AAA86440.1.
AF158101 Genomic DNA. Translation: AAD42538.1.
RefSeqiNP_049868.1. NC_000866.4.

Genome annotation databases

GeneIDi1258794.
KEGGivg:1258794.

Similar proteinsi

Entry informationi

Entry nameiARN_BPT4
AccessioniPrimary (citable) accession number: P39510
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 10, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references