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Protein

Spanin, outer lipoprotein subunit

Gene

y13J

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the spanin complex that disrupts the host outer membrane and participates in cell lysis during virus exit. The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans. Host outer membrane disruption is possibly due to local fusion between the inner and outer membrane performed by the spanin complex (By similarity).By similarity1 Publication

GO - Biological processi

  • cytolysis Source: UniProtKB-KW
  • cytolysis by virus of host cell Source: CACAO

Keywordsi

Biological processCytolysis, Host cell lysis by virus, Viral release from host cell

Protein family/group databases

TCDBi9.B.7.1.1. the spanin3 (spanin3) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Spanin, outer lipoprotein subunit
Short name:
o-spanin
Gene namesi
Name:y13J
Synonyms:pseT.2
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 99PeriplasmicSequence analysisAdd BLAST82

GO - Cellular componenti

Keywords - Cellular componenti

Host cell outer membrane, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000016518317 – 99Spanin, outer lipoprotein subunitAdd BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi17N-palmitoyl cysteine; by hostBy similarity1
Lipidationi17S-diacylglycerol cysteine; by hostBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts (via C-terminus) with the spanin inner membrane subunit (via C-terminus). Part of the spanin complex which spans the entire periplasmic space. The spanin complex is composed of spanin inner membrane subunit and spanin outer membrane subunit (By similarity).By similarity

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiVOG090001CG.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLSAVILS IGLLVGCSTK PLEVKKETVH PNWPVQIKSY DEAKLSWQVK
60 70 80 90
VIDGKAWVGM PFEDSQEFRI WLNDVKRYVH DQKTMXCYYR QELKEDKCK
Length:99
Mass (Da):11,628
Last modified:August 15, 2003 - v3
Checksum:i4E710D17320DE34F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158101 Genomic DNA. Translation: AAD42644.2.
RefSeqiNP_049836.2. NC_000866.4.

Genome annotation databases

GeneIDi1258607.
KEGGivg:1258607.

Similar proteinsi

Entry informationi

Entry nameiSPAN2_BPT4
AccessioniPrimary (citable) accession number: P39503
Secondary accession number(s): Q9T0T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: August 15, 2003
Last modified: October 25, 2017
This is version 56 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome