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P39475

- DHE4_SULSH

UniProt

P39475 - DHE4_SULSH

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Protein

NADP-specific glutamate dehydrogenase

Gene

gdhA

Organism
Sulfolobus shibatae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei81 – 811PROSITE-ProRule annotation

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.4.1.4. 6162.

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
OrganismiSulfolobus shibatae
Taxonomic identifieri2286 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 390›390NADP-specific glutamate dehydrogenasePRO_0000182781Add
BLAST

Interactioni

Subunit structurei

Homohexamer.

Structurei

3D structure databases

ProteinModelPortaliP39475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P39475-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LDTLEALSQP ERVIQVKIQI RGSDGKLKTF MGWRSQHNSA LGPYKGGVRY
60 70 80 90 100
SPNVTQDEVI ALSMIMTWKN SLLLLPYGGG KGGIRVDPKK LTLKELEDLS
110 120 130 140 150
RKYVQLIHNY LGSDVDIPAP DINTNPQTMA WFLDEYIKIT GEVDFAVFTG
160 170 180 190 200
KPSELGGIGV RLYSTGLGVA TIAREAANKF IGGIEGSRVI IQGFGNVGSF
210 220 230 240 250
TAKFLNEMGA KIIGVSDIGG GVISDDGIDV NKALEVVQST GSVVNYPEGK
260 270 280 290 300
KVTNEELLTS DCDILIPAAV ENVINKFNAP KVKAKLIVEG ANGPLAADAD
310 320 330 340 350
EIIKQRGIVV IPDILANAGG VVGSYVEWAN NKSGGIISDE EAKKLIIDRM
360 370 380 390
TNAFNALYEF HKRKFADQDL RTVAMALRVD RVVGMKARAI
Length:390
Mass (Da):42,091
Last modified:February 1, 1995 - v1
Checksum:iBCB9ACFE6AC9CEB2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73990 Genomic DNA. Translation: CAA52168.1.
PIRiS37407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73990 Genomic DNA. Translation: CAA52168.1 .
PIRi S37407.

3D structure databases

ProteinModelPortali P39475.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 1.4.1.4. 6162.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "PCR-mediated cloning and sequencing of the gene encoding glutamate dehydrogenase from the archaeon Sulfolobus shibatae: identification of putative amino-acid signatures for extremophilic adaptation."
    Benachenhou-Lahfa N., Labedan B., Forterre P.
    Gene 140:17-24(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDHE4_SULSH
AccessioniPrimary (citable) accession number: P39475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3