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P39475 (DHE4_SULSH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADP-specific glutamate dehydrogenase

Short name=NADP-GDH
EC=1.4.1.4
Gene names
Name:gdhA
OrganismSulfolobus shibatae
Taxonomic identifier2286 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length390 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Subunit structure

Homohexamer.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutamate dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 390›390NADP-specific glutamate dehydrogenase
PRO_0000182781

Sites

Active site811 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P39475 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: BCB9ACFE6AC9CEB2

FASTA39042,091
        10         20         30         40         50         60 
LDTLEALSQP ERVIQVKIQI RGSDGKLKTF MGWRSQHNSA LGPYKGGVRY SPNVTQDEVI 

        70         80         90        100        110        120 
ALSMIMTWKN SLLLLPYGGG KGGIRVDPKK LTLKELEDLS RKYVQLIHNY LGSDVDIPAP 

       130        140        150        160        170        180 
DINTNPQTMA WFLDEYIKIT GEVDFAVFTG KPSELGGIGV RLYSTGLGVA TIAREAANKF 

       190        200        210        220        230        240 
IGGIEGSRVI IQGFGNVGSF TAKFLNEMGA KIIGVSDIGG GVISDDGIDV NKALEVVQST 

       250        260        270        280        290        300 
GSVVNYPEGK KVTNEELLTS DCDILIPAAV ENVINKFNAP KVKAKLIVEG ANGPLAADAD 

       310        320        330        340        350        360 
EIIKQRGIVV IPDILANAGG VVGSYVEWAN NKSGGIISDE EAKKLIIDRM TNAFNALYEF 

       370        380        390 
HKRKFADQDL RTVAMALRVD RVVGMKARAI 

« Hide

References

[1]"PCR-mediated cloning and sequencing of the gene encoding glutamate dehydrogenase from the archaeon Sulfolobus shibatae: identification of putative amino-acid signatures for extremophilic adaptation."
Benachenhou-Lahfa N., Labedan B., Forterre P.
Gene 140:17-24(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X73990 Genomic DNA. Translation: CAA52168.1.
PIRS37407.

3D structure databases

ProteinModelPortalP39475.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA1.4.1.4. 6162.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE4_SULSH
AccessionPrimary (citable) accession number: P39475
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 16, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families