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P39464 (GGPS_SULAC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Geranylgeranyl pyrophosphate synthase
Short name=GGPP synthase
Short name=GGPS
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase
EC=2.5.1.1
Farnesyl diphosphate synthase
Farnesyltranstransferase
EC=2.5.1.29
Geranyltranstransferase
EC=2.5.1.10
Gene names
Name:gds
Ordered Locus Names:Saci_0092
OrganismSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) [Complete proteome] [HAMAP]
Taxonomic identifier330779 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids.

Catalytic activity

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Geranylgeranyl pyrophosphate synthase
PRO_0000123973

Sites

Metal binding821Magnesium 1 By similarity
Metal binding821Magnesium 2 By similarity
Metal binding861Magnesium 1 By similarity
Metal binding861Magnesium 2 By similarity
Metal binding2161Magnesium 3 By similarity
Binding site431Isopentenyl diphosphate By similarity
Binding site461Isopentenyl diphosphate By similarity
Binding site751Isopentenyl diphosphate By similarity
Binding site911Dimethylallyl diphosphate By similarity
Binding site921Isopentenyl diphosphate By similarity
Binding site1751Dimethylallyl diphosphate By similarity
Binding site1761Dimethylallyl diphosphate By similarity
Binding site2131Dimethylallyl diphosphate By similarity
Binding site2301Dimethylallyl diphosphate By similarity
Binding site2401Dimethylallyl diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P39464 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 69EEDA7CD4BA1BCB

FASTA33036,874
        10         20         30         40         50         60 
MSYFDNYFNE IVNSVNDIIK SYISGDVPKL YEASYHLFTS GGKRLRPLIL TISSDLFGGQ 

        70         80         90        100        110        120 
RERAYYAGAA IEVLHTFTLV HDDIMDQDNI RRGLPTVHVK YGLPLAILAG DLLHAKAFQL 

       130        140        150        160        170        180 
LTQALRGLPS ETIIKAFDIF TRSIIIISEG QAVDMEFEDR IDIKEQEYLD MISRKTAALF 

       190        200        210        220        230        240 
SASSSIGALI AGANDNDVRL MSDFGTNLGI AFQIVDDILG LTADEKELGK PVFSDIREGK 

       250        260        270        280        290        300 
KTILVIKTLE LCKEDEKKIV LKALGNKSAS KEELMSSADI IKKYSLDYAY NLAEKYYKNA 

       310        320        330 
IDSLNQVSSK SDIPGKALKY LAEFTIRRRK

« Hide

References

« Hide 'large scale' references
[1]"Archaebacterial ether-linked lipid biosynthetic gene. Expression cloning, sequencing, and characterization of geranylgeranyl-diphosphate synthase."
Ohnuma S., Suzuki M., Nishino T.
J. Biol. Chem. 269:14792-14797(1994) [PubMed: 8182085] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.
[2]"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
J. Bacteriol. 187:4992-4999(2005) [PubMed: 15995215] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D28748 Genomic DNA. Translation: BAA43200.1.
CP000077 Genomic DNA. Translation: AAY79519.1.
PIRA54058.
RefSeqYP_254812.1. NC_007181.1.

3D structure databases

ProteinModelPortalP39464.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3473868.
GenomeReviewsGene locus Saci_0092 in contig CP000077_GR.
KEGGsai:Saci_0092.
NMPDRfig|330779.3.peg.2059.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG732667.
OMALLYAKAF.
PhylomeDBP39464.
ProtClustDBCLSK802541.

Enzyme and pathway databases

BioCycSACI330779:SACI_0092-MONOMER.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
KOK13787.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGPS_SULAC
AccessionPrimary (citable) accession number: P39464
Secondary accession number(s): Q4JCG0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 14, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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