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Protein

NAD-dependent alcohol dehydrogenase

Gene

adh

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Zinc 1; catalytic
Metal bindingi68 – 681Zinc 1; catalytic
Metal bindingi98 – 981Zinc 2
Metal bindingi101 – 1011Zinc 2
Metal bindingi104 – 1041Zinc 2
Metal bindingi112 – 1121Zinc 2
Metal bindingi154 – 1541Zinc 1; catalytic

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-2351-MONOMER.
BRENDAi1.1.1.1. 6163.
SABIO-RKP39462.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:adh
Ordered Locus Names:SSO2536
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347NAD-dependent alcohol dehydrogenasePRO_0000160753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111N6-methyllysine; partial1 Publication
Modified residuei213 – 2131N6-methyllysine; partial1 Publication

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Homodimer and homotetramer.

Protein-protein interaction databases

STRINGi273057.SSO2536.

Structurei

Secondary structure

1
347
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65Combined sources
Beta strandi8 – 114Combined sources
Beta strandi14 – 174Combined sources
Beta strandi28 – 3710Combined sources
Helixi40 – 445Combined sources
Turni45 – 473Combined sources
Beta strandi49 – 524Combined sources
Turni54 – 585Combined sources
Beta strandi62 – 654Combined sources
Beta strandi69 – 779Combined sources
Beta strandi89 – 924Combined sources
Beta strandi99 – 1013Combined sources
Helixi102 – 1054Combined sources
Helixi109 – 1113Combined sources
Turni118 – 1203Combined sources
Beta strandi125 – 1339Combined sources
Helixi135 – 1373Combined sources
Beta strandi138 – 1403Combined sources
Beta strandi142 – 1443Combined sources
Helixi146 – 1494Combined sources
Helixi150 – 1534Combined sources
Helixi155 – 16511Combined sources
Beta strandi173 – 1775Combined sources
Turni178 – 1803Combined sources
Helixi182 – 19413Combined sources
Beta strandi198 – 2058Combined sources
Helixi206 – 21510Combined sources
Beta strandi218 – 2225Combined sources
Turni223 – 2253Combined sources
Helixi228 – 2358Combined sources
Turni236 – 2383Combined sources
Beta strandi241 – 2477Combined sources
Helixi251 – 2544Combined sources
Helixi257 – 2604Combined sources
Beta strandi261 – 2699Combined sources
Beta strandi276 – 2805Combined sources
Helixi281 – 2877Combined sources
Beta strandi290 – 2934Combined sources
Helixi299 – 31012Combined sources
Beta strandi319 – 3235Combined sources
Helixi324 – 3263Combined sources
Helixi327 – 3359Combined sources
Beta strandi341 – 3466Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JVBX-ray1.85A1-347[»]
1NTOX-ray1.94A/B/C/D/E/H1-347[»]
1NVGX-ray2.50A1-347[»]
1R37X-ray2.30A/B1-347[»]
3I4CX-ray2.00A/B/C/D/E/H1-347[»]
ProteinModelPortaliP39462.
SMRiP39462. Positions 1-347.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39462.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01455. Archaea.
COG1064. LUCA.
HOGENOMiHOG000294685.
InParanoidiP39462.
KOiK13953.
OMAiDPDRVQK.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVRLVEIG KPLSLQEIGV PKPKGPQVLI KVEAAGVCHS DVHMRQGRFG
60 70 80 90 100
NLRIVEDLGV KLPVTLGHEI AGKIEEVGDE VVGYSKGDLV AVNPWQGEGN
110 120 130 140 150
CYYCRIGEEH LCDSPRWLGI NFDGAYAEYV IVPHYKYMYK LRRLNAVEAA
160 170 180 190 200
PLTCSGITTY RAVRKASLDP TKTLLVVGAG GGLGTMAVQI AKAVSGATII
210 220 230 240 250
GVDVREEAVE AAKRAGADYV INASMQDPLA EIRRITESKG VDAVIDLNNS
260 270 280 290 300
EKTLSVYPKA LAKQGKYVMV GLFGADLHYH APLITLSEIQ FVGSLVGNQS
310 320 330 340
DFLGIMRLAE AGKVKPMITK TMKLEEANEA IDNLENFKAI GRQVLIP
Length:347
Mass (Da):37,569
Last modified:February 1, 1995 - v1
Checksum:i755848A249D4F4A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51211 Genomic DNA. Translation: AAB24546.1.
AJ010590 Genomic DNA. Translation: CAA09258.1.
AE006641 Genomic DNA. Translation: AAK42665.1.
PIRiA44245.
RefSeqiWP_009990984.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK42665; AAK42665; SSO2536.
GeneIDi27428834.
KEGGisso:SSO2536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51211 Genomic DNA. Translation: AAB24546.1.
AJ010590 Genomic DNA. Translation: CAA09258.1.
AE006641 Genomic DNA. Translation: AAK42665.1.
PIRiA44245.
RefSeqiWP_009990984.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JVBX-ray1.85A1-347[»]
1NTOX-ray1.94A/B/C/D/E/H1-347[»]
1NVGX-ray2.50A1-347[»]
1R37X-ray2.30A/B1-347[»]
3I4CX-ray2.00A/B/C/D/E/H1-347[»]
ProteinModelPortaliP39462.
SMRiP39462. Positions 1-347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO2536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK42665; AAK42665; SSO2536.
GeneIDi27428834.
KEGGisso:SSO2536.

Phylogenomic databases

eggNOGiarCOG01455. Archaea.
COG1064. LUCA.
HOGENOMiHOG000294685.
InParanoidiP39462.
KOiK13953.
OMAiDPDRVQK.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-2351-MONOMER.
BRENDAi1.1.1.1. 6163.
SABIO-RKP39462.

Miscellaneous databases

EvolutionaryTraceiP39462.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH_SULSO
AccessioniPrimary (citable) accession number: P39462
Secondary accession number(s): O74076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.