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Protein

NAD-dependent alcohol dehydrogenase

Gene

adh

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Metal bindingi154Zinc 1; catalytic1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1. 6163.
SABIO-RKP39462.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:adh
Ordered Locus Names:SSO2536
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607531 – 347NAD-dependent alcohol dehydrogenaseAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11N6-methyllysine; partial1 Publication1
Modified residuei213N6-methyllysine; partial1 Publication1

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Homodimer and homotetramer.

Protein-protein interaction databases

STRINGi273057.SSO2536.

Structurei

Secondary structure

1347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Beta strandi8 – 11Combined sources4
Beta strandi14 – 17Combined sources4
Beta strandi28 – 37Combined sources10
Helixi40 – 44Combined sources5
Turni45 – 47Combined sources3
Beta strandi49 – 52Combined sources4
Turni54 – 58Combined sources5
Beta strandi62 – 65Combined sources4
Beta strandi69 – 77Combined sources9
Beta strandi89 – 92Combined sources4
Beta strandi99 – 101Combined sources3
Helixi102 – 105Combined sources4
Helixi109 – 111Combined sources3
Turni118 – 120Combined sources3
Beta strandi125 – 133Combined sources9
Helixi135 – 137Combined sources3
Beta strandi138 – 140Combined sources3
Beta strandi142 – 144Combined sources3
Helixi146 – 149Combined sources4
Helixi150 – 153Combined sources4
Helixi155 – 165Combined sources11
Beta strandi173 – 177Combined sources5
Turni178 – 180Combined sources3
Helixi182 – 194Combined sources13
Beta strandi198 – 205Combined sources8
Helixi206 – 215Combined sources10
Beta strandi218 – 222Combined sources5
Turni223 – 225Combined sources3
Helixi228 – 235Combined sources8
Turni236 – 238Combined sources3
Beta strandi241 – 247Combined sources7
Helixi251 – 254Combined sources4
Helixi257 – 260Combined sources4
Beta strandi261 – 269Combined sources9
Beta strandi276 – 280Combined sources5
Helixi281 – 287Combined sources7
Beta strandi290 – 293Combined sources4
Helixi299 – 310Combined sources12
Beta strandi319 – 323Combined sources5
Helixi324 – 326Combined sources3
Helixi327 – 335Combined sources9
Beta strandi341 – 346Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JVBX-ray1.85A1-347[»]
1NTOX-ray1.94A/B/C/D/E/H1-347[»]
1NVGX-ray2.50A1-347[»]
1R37X-ray2.30A/B1-347[»]
3I4CX-ray2.00A/B/C/D/E/H1-347[»]
ProteinModelPortaliP39462.
SMRiP39462.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39462.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01455. Archaea.
COG1064. LUCA.
HOGENOMiHOG000294685.
InParanoidiP39462.
KOiK13953.
OMAiDPDRVQK.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVRLVEIG KPLSLQEIGV PKPKGPQVLI KVEAAGVCHS DVHMRQGRFG
60 70 80 90 100
NLRIVEDLGV KLPVTLGHEI AGKIEEVGDE VVGYSKGDLV AVNPWQGEGN
110 120 130 140 150
CYYCRIGEEH LCDSPRWLGI NFDGAYAEYV IVPHYKYMYK LRRLNAVEAA
160 170 180 190 200
PLTCSGITTY RAVRKASLDP TKTLLVVGAG GGLGTMAVQI AKAVSGATII
210 220 230 240 250
GVDVREEAVE AAKRAGADYV INASMQDPLA EIRRITESKG VDAVIDLNNS
260 270 280 290 300
EKTLSVYPKA LAKQGKYVMV GLFGADLHYH APLITLSEIQ FVGSLVGNQS
310 320 330 340
DFLGIMRLAE AGKVKPMITK TMKLEEANEA IDNLENFKAI GRQVLIP
Length:347
Mass (Da):37,569
Last modified:February 1, 1995 - v1
Checksum:i755848A249D4F4A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51211 Genomic DNA. Translation: AAB24546.1.
AJ010590 Genomic DNA. Translation: CAA09258.1.
AE006641 Genomic DNA. Translation: AAK42665.1.
PIRiA44245.
RefSeqiWP_009990984.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK42665; AAK42665; SSO2536.
GeneIDi27428834.
KEGGisso:SSO2536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51211 Genomic DNA. Translation: AAB24546.1.
AJ010590 Genomic DNA. Translation: CAA09258.1.
AE006641 Genomic DNA. Translation: AAK42665.1.
PIRiA44245.
RefSeqiWP_009990984.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JVBX-ray1.85A1-347[»]
1NTOX-ray1.94A/B/C/D/E/H1-347[»]
1NVGX-ray2.50A1-347[»]
1R37X-ray2.30A/B1-347[»]
3I4CX-ray2.00A/B/C/D/E/H1-347[»]
ProteinModelPortaliP39462.
SMRiP39462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO2536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK42665; AAK42665; SSO2536.
GeneIDi27428834.
KEGGisso:SSO2536.

Phylogenomic databases

eggNOGiarCOG01455. Archaea.
COG1064. LUCA.
HOGENOMiHOG000294685.
InParanoidiP39462.
KOiK13953.
OMAiDPDRVQK.

Enzyme and pathway databases

BRENDAi1.1.1.1. 6163.
SABIO-RKP39462.

Miscellaneous databases

EvolutionaryTraceiP39462.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH_SULSO
AccessioniPrimary (citable) accession number: P39462
Secondary accession number(s): O74076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.