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P39457

- PLB1_PENCH

UniProt

P39457 - PLB1_PENCH

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Protein
Lysophospholipase
Gene
N/A
Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase (EC:3.1.1.5)
Alternative name(s):
Phospholipase B
OrganismiPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifieri5076 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 9›91 Publication
Chaini10 – 612603Lysophospholipase
PRO_0000024639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ ? Reviewed prediction
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi81 – 811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi150 – 1501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi223 – 2231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi267 – 2671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi306 – 3061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi335 – 3351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi427 – 4271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi440 – 4401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi446 – 4461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi477 – 4771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi498 – 4981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi526 – 5261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi532 – 5321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi567 – 5671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi571 – 5711N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP39457.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 571548PLA2c
Add
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.
Contains 1 PLA2c domain.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39457-1 [UniParc]FASTAAdd to Basket

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DITFAGVQRA LPNAPDGYVP TSVSCPASRP TVRSAAKLST NETSWLEVRR    50
GKTLSALKDF FGHVKVGDYD VGAYLDKHSG NSSSLPNIGI AVSGGGWRAL 100
MNGAGAVKAF DSRTDNATAT GHLGGLLQSA TYISGLSGGS WLLGSIYINN 150
FTTVDKLQTH EAGSVWQFGN SIIEGPDAGG IQLLDSAGYY KDLADAVDGK 200
KKAGFDTTLT DIWGRALSYQ MFNASNGGLS YTWSSIADTP EFQDGDYPMP 250
FVVADGRNPG ELVIGSNSTV YEFNPWEFGT FDPTIFGFVP LEYLGSKFEG 300
GSLPSNESCI RGFDSAGFVI GTSSSLFNQF LLQINTTSLP SFIKDVFNGI 350
LFDLDKSQND IASYDPNPFY KYNEHSSPYA AQKLLDVVDG GEDGQNVPLH 400
PLIQPERHVD VIFAVDSSAD TDYFWPNGTS LVATYERSLN SSGIANGTAF 450
PAVPDQNTFI NLGLSTRPSF FGCDSSNQTG PSPLVVYIPN APYSYHSNIS 500
TFQLSTDDAE RDNIILNGYE VATMANSTLD DNWTACVACA ILSRSFERTG 550
TTLPDICSQC FDRYCWNGTV NSTRPESYDP AFYLADNSMA SVSLPTMLST 600
VVAAGLAMLI LV 612
Length:612
Mass (Da):65,751
Last modified:February 1, 1995 - v1
Checksum:i7C32F819C3C1ABE5
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60348 mRNA. Translation: CAA42906.1.
PIRiS29318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60348 mRNA. Translation: CAA42906.1 .
PIRi S29318.

3D structure databases

ProteinModelPortali P39457.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of protein moiety of Penicillium notatum phospholipase B deduced from the cDNA."
    Masuda N., Kitamura N., Saito K.
    Eur. J. Biochem. 202:783-787(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 10-20 AND 185-199.
    Strain: ATCC 34514 / NBRC 4640.

Entry informationi

Entry nameiPLB1_PENCH
AccessioniPrimary (citable) accession number: P39457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 13, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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