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Reviewed, UniProtKB/Swiss-Prot P39451 (ADHP_ECOLI)

Last modified June 16, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase, propanol-preferring
    EC=1.1.1.1
Gene names
Name: adhP
Synonyms: yddN
Ordered Locus Names: b1478, JW1474
OrganismEscherichia coli (strain K12) [Complete proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

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Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Preferred specificity is towards 1-propanol.

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionalcohol dehydrogenase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336Alcohol dehydrogenase, propanol-preferring
PRO_0000160740

Sites

Metal binding371Zinc 1; catalytic By similarity
Metal binding581Zinc 1; catalytic By similarity
Metal binding891Zinc 2 By similarity
Metal binding921Zinc 2 By similarity
Metal binding951Zinc 2 By similarity
Metal binding1031Zinc 2 By similarity
Metal binding1451Zinc 1; catalytic By similarity

Experimental info

Sequence conflict341C → P AA sequence Ref.4
Sequence conflict901G → R Ref.5
Sequence conflict1041R → P Ref.5
Sequence conflict1081N → K Ref.5
Sequence conflict1121S → G Ref.5
Sequence conflict117 – 1182MA → RV Ref.5

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Sequences

Sequence LengthMass (Da)Tools
P39451-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 8A9080F273866947

FASTA33635,380
        10         20         30         40         50         60 
MKAAVVTKDH HVDVTYKTLR SLKHGEALLK MECCGVCHTD LHVKNGDFGD KTGVILGHEG 

        70         80         90        100        110        120 
IGVVAEVGPG VTSLKPGDRA SVAWFYEGCG HCEYCNSGNE TLCRSVKNAG YSVDGGMAEE 

       130        140        150        160        170        180 
CIVVADYAVK VPDGLDSAAA SSITCAGVTT YKAVKLSKIR PGQWIAIYGL GGLGNLALQY 

       190        200        210        220        230        240 
AKNVFNAKVI AIDVNDEQLK LATEMGADLA INSHTEDAAK IVQEKTGGAH AAVVTAVAKA 

       250        260        270        280        290        300 
AFNSAVDAVR AGGRVVAVGL PPESMSLDIP RLVLDGIEVV GSLVGTRQDL TEAFQFAAEG 

       310        320        330 
KVVPKVALRP LADINTIFTE MEEGKIRGRM VIDFRH

« Hide

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References

« Hide 'large scale' references
[1]"A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map."
Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K. expand/collapse author list , Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.
DNA Res. 3:363-377(1996) [PubMed: 9097039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]Harayama S.
Submitted (OCT-1994) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1-35, CHARACTERIZATION.
[5]"Bacterial transposon Tn7 utilizes two different classes of target sites."
Kubo K.M., Craig N.L.
J. Bacteriol. 172:2774-2778(1990) [PubMed: 2158980] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 87-118.

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Cross-references

Sequence databases

U00096 Genomic DNA. Translation: AAC74551.1. Different initiation.
AP009048 Genomic DNA. Translation: BAA15126.1.
M31532 Genomic DNA. No translation available.
PIRA64901.
RefSeqAP_002101.1.
NP_415995.4.

3D structure databases

HSSPHSSP built from PDB template 1JVB based on UniProtKB P39462.
ModBaseSearch...

Genome annotation databases

GeneID946036.
GenomeReviewsGene locus JW1474 in contig AP009048_GR.
Gene locus b1478 in contig U00096_GR.
KEGGecj:JW1474.
eco:b1478.

Organism-specific databases

EchoBASEEB2506.
EcoGeneEG12622. adhP.
CMRSearch...

Phylogenomic databases

HOGENOMP39451.
OMAP39451. VRPGQWI.

Enzyme and pathway databases

BioCycEcoCyc:ADHP-MON.
MetaCyc:ADHP-MON.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADHP_ECOLI
AccessionPrimary (citable) accession number: P39451
Secondary accession number(s): P76126, P78157, P78268
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents