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Protein

S-(hydroxymethyl)glutathione dehydrogenase

Gene

frmA

Organism
Photobacterium damsela subsp. piscicida (Pasteurella piscicida)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.
An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Zinc 1; catalyticBy similarity1
Metal bindingi62Zinc 1; catalyticBy similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi169Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
Alternative name(s):
Alcohol dehydrogenase class-3 (EC:1.1.1.1)
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
Gene namesi
Name:frmA
Encoded oniPlasmid R1 Publication
OrganismiPhotobacterium damsela subsp. piscicida (Pasteurella piscicida)
Taxonomic identifieri38294 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607771 – 369S-(hydroxymethyl)glutathione dehydrogenaseAdd BLAST369

Proteomic databases

PRIDEiP39450.

Structurei

3D structure databases

ProteinModelPortaliP39450.
SMRiP39450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd08300. alcohol_DH_class_III. 1 hit.
Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P39450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSRAAVAFG PGLPLEIVEI DVAPPKKGEV LVKISHTGVC HTDAYTLSGD
60 70 80 90 100
DPEGLFPVVL GHEGAGVVVE VGEGVTSVKP GDHVIPLYTA ECGECDFCTS
110 120 130 140 150
GKTNLCVAVR ETQGKGVMPD ATSRFFVNGQ PLYHYMGCST FSEYTVVAEV
160 170 180 190 200
SLAKINPQAN AEQVCLLGCG VTTGIGAVHN TAKVQEGDSV AVFGLGGIGL
210 220 230 240 250
AVVQGARQAK AGRIFAIDTN PSKFELAKQF GATDCINPND YDKPVQQVLV
260 270 280 290 300
EMTKWGVDHT FECIGNVNVM RSALESAHRG WGQSVIIGVA GAGKEISTRP
310 320 330 340 350
FQLVTGRVWK GTAFGGVKGR TQLPGMVEDA MSGKIELAPF VTHTMELDKI
360
NEAFDLMHDG KSIRTVIHY
Length:369
Mass (Da):39,094
Last modified:February 1, 1995 - v1
Checksum:iACAEA4581048901C
GO

Sequence cautioni

The sequence BAA03719 differs from that shown. Reason: Frameshift at position 128.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16172 Genomic DNA. Translation: BAA03719.1. Frameshift.
RefSeqiYP_003023972.1. NC_012919.1.
YP_908417.1. NC_008612.1.
YP_908601.1. NC_008613.1.

Genome annotation databases

GeneIDi4549487.
4549496.
8242395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16172 Genomic DNA. Translation: BAA03719.1. Frameshift.
RefSeqiYP_003023972.1. NC_012919.1.
YP_908417.1. NC_008612.1.
YP_908601.1. NC_008613.1.

3D structure databases

ProteinModelPortaliP39450.
SMRiP39450.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP39450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4549487.
4549496.
8242395.

Family and domain databases

CDDicd08300. alcohol_DH_class_III. 1 hit.
Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFRMA_PHODP
AccessioniPrimary (citable) accession number: P39450
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 15, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.