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Protein

Trk system potassium uptake protein TrkA

Gene

trkA

Organism
Vibrio alginolyticus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of a potassium transport system.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30NAD 1By similarity1
Binding sitei98NAD 1; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 11NAD 1By similarity5
Nucleotide bindingi73 – 74NAD 1By similarity2
Nucleotide bindingi234 – 262NAD 2Sequence analysisAdd BLAST29

GO - Molecular functioni

Keywordsi

Biological processIon transport, Potassium transport, Transport
LigandNAD, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Trk system potassium uptake protein TrkA
Short name:
K(+)-uptake protein TrkA
Gene namesi
Name:trkA
OrganismiVibrio alginolyticus
Taxonomic identifieri663 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001487191 – 458Trk system potassium uptake protein TrkAAdd BLAST458

Structurei

3D structure databases

ProteinModelPortaliP39448.
SMRiP39448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 131RCK N-terminal 1PROSITE-ProRule annotationAdd BLAST130
Domaini143 – 227RCK C-terminal 1PROSITE-ProRule annotationAdd BLAST85
Domaini234 – 356RCK N-terminal 2PROSITE-ProRule annotationAdd BLAST123
Domaini368 – 453RCK C-terminal 2PROSITE-ProRule annotationAdd BLAST86

Domaini

The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105C1A. Bacteria.
COG0569. LUCA.

Family and domain databases

Gene3Di3.30.70.1450. 2 hits.
InterProiView protein in InterPro
IPR006036. K_uptake_TrkA.
IPR036291. NAD(P)-bd_dom_sf.
IPR006037. RCK_C.
IPR036721. RCK_C_sf.
IPR003148. RCK_N.
PfamiView protein in Pfam
PF02080. TrkA_C. 2 hits.
PF02254. TrkA_N. 2 hits.
PRINTSiPR00335. KUPTAKETRKA.
SUPFAMiSSF116726. SSF116726. 2 hits.
SSF51735. SSF51735. 2 hits.
PROSITEiView protein in PROSITE
PS51202. RCK_C. 2 hits.
PS51201. RCK_N. 2 hits.

Sequencei

Sequence statusi: Complete.

P39448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIIILGAGQ VGGTLAENLV GENNDITIVD NNADRLRELQ DKYDLRVVNG
60 70 80 90 100
HASHPDVLHE AGAQDADMLV AVTNTDETNM AACQVAFTLF NTPNRVARIR
110 120 130 140 150
SPEYLAEKEA LFKSGAIPVD HLIAPEELVT SYIERLIQYP GALQVVSFAE
160 170 180 190 200
QKVSLVAVKA YYGGPLVGNA LSALREHMPH IDTRVAAIFR QGRPIRPQGT
210 220 230 240 250
TIIEADDEVF FVAASNHIRS VMSELQRLEK PYRRIMIVGG GNIGASLAKR
260 270 280 290 300
LEQNYSVKLI ERNYQRAEKL SEELENTIVF CGDAADQELL SEENIDQVDV
310 320 330 340 350
FIALTNEDET NIMSAMLAKR MGAKKVMVLI QRGAYVDLVQ GGVIDVAISP
360 370 380 390 400
QQATISALLT HVRRADIVNV SSLRRGAAEA IEAVAHGDES TSKVVGRAIG
410 420 430 440 450
DIKLPPGTTI GAIVRGEEVL IAHDRTVIEQ DDHVVMFLVN KKYVSDVEAL

FQPSPFFL
Length:458
Mass (Da):50,125
Last modified:February 1, 1995 - v1
Checksum:i309B2AC490C03472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28477 Genomic DNA. Translation: BAA05838.1.
D86411 Genomic DNA. Translation: BAA31228.1.
PIRiS50220.
RefSeqiWP_005394041.1. NZ_MAKC01000151.1.

Similar proteinsi

Entry informationi

Entry nameiTRKA_VIBAL
AccessioniPrimary (citable) accession number: P39448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program