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P39442 (HCY_NATPH) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Halocyanin
Gene names
Name:hcy
OrganismNatronomonas pharaonis (Natronobacterium pharaonis)
Taxonomic identifier2257 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Electron donor. Binds one copper ion.

Subcellular location

Cell membrane; Lipid-anchor.

Sequence similarities

Contains 1 plastocyanin-like domain.

Biophysicochemical properties

Redox potential:

E0 is +183 mV.

Mass spectrometry

Molecular mass is 15456±1.5 Da from positions 25 - 163. Determined by ESI. Ref.1

Ontologies

Keywords
   Biological processElectron transport
Transport
   Cellular componentCell membrane
Membrane
   DomainSignal
   LigandCopper
Metal-binding
   PTMAcetylation
Lipoprotein
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processoxidation-reduction process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncopper ion binding

Inferred from electronic annotation. Source: InterPro

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 163139Halocyanin
PRO_0000002871

Regions

Domain48 – 163116Plastocyanin-like

Sites

Metal binding1101Copper By similarity
Metal binding1481Copper By similarity
Metal binding1511Copper By similarity
Metal binding1561Copper By similarity

Amino acid modifications

Modified residue251N-acetylcysteine
Lipidation251S-archaeol cysteine

Secondary structure

....................... 163
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P39442 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: DB180417F8B0BEE6

FASTA16317,222
        10         20         30         40         50         60 
MKDISRRRFV LGTGATVAAA TLAGCNGNGN GNGNGNGNGE PDTPEGRADQ FLTDNDALMY 

        70         80         90        100        110        120 
DGDITDETGQ DEVVVVTGAG NNGFAFDPAA IRVDVGTTVT WEWTGDGGAH NVVSEPESDF 

       130        140        150        160 
EFESDRVDEE GFTFEQTFDD EGVALYVCTP HRAQGMYGAV IVE 

« Hide

References

[1]"The primary structure of halocyanin, an archaeal blue copper protein, predicts a lipid anchor for membrane fixation."
Mattar S., Scharf B., Kent S.B.H., Rodewald K., Oesterhelt D., Engelhard M.
J. Biol. Chem. 269:14939-14945(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, MASS SPECTROMETRY.
Strain: SP-1 / 28.
[2]"Halocyanin, an archaebacterial blue copper protein (type I) from Natronobacterium pharaonis."
Scharf B., Engelhard M.
Biochemistry 32:12894-12900(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, PROTEIN SEQUENCE OF 144-163.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z30236 Genomic DNA. Translation: CAA82942.1.
PIRA53792.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1N3Dmodel-A69-163[»]
ProteinModelPortalP39442.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.420. 1 hit.
InterProIPR000923. BlueCu_1.
IPR028871. BlueCu_1_BS.
IPR008972. Cupredoxin.
IPR017533. Halocyanin.
IPR006311. TAT_signal.
[Graphical view]
PfamPF00127. Copper-bind. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
TIGRFAMsTIGR03102. halo_cynanin. 1 hit.
PROSITEPS00196. COPPER_BLUE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHCY_NATPH
AccessionPrimary (citable) accession number: P39442
Secondary accession number(s): Q9UWL3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 19, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references