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P39442

- HCY_NATPH

UniProt

P39442 - HCY_NATPH

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Protein

Halocyanin

Gene

hcy

Organism
Natronomonas pharaonis (Natronobacterium pharaonis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Electron donor. Binds one copper ion.

Redox potential

E0 is +183 mV.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi110 – 1101CopperBy similarity
Metal bindingi148 – 1481CopperBy similarity
Metal bindingi151 – 1511CopperBy similarity
Metal bindingi156 – 1561CopperBy similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. electron carrier activity Source: InterPro

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Halocyanin
Gene namesi
Name:hcy
OrganismiNatronomonas pharaonis (Natronobacterium pharaonis)
Taxonomic identifieri2257 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 163139HalocyaninPRO_0000002871Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251N-acetylcysteine1 Publication
Lipidationi25 – 251S-archaeol cysteine1 Publication

Keywords - PTMi

Acetylation, Lipoprotein

Structurei

Secondary structure

1
163
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi72 – 765
Beta strandi78 – 825
Beta strandi85 – 928
Beta strandi98 – 1036
Beta strandi105 – 1084
Turni116 – 1183
Beta strandi119 – 1224
Beta strandi133 – 1375
Beta strandi144 – 1474
Helixi149 – 1524
Turni153 – 1553
Beta strandi157 – 1615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1N3Dmodel-A69-163[»]
ProteinModelPortaliP39442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 163116Plastocyanin-likeAdd
BLAST

Sequence similaritiesi

Contains 1 plastocyanin-like domain.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR000923. BlueCu_1.
IPR028871. BlueCu_1_BS.
IPR008972. Cupredoxin.
IPR017533. Halocyanin.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF00127. Copper-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
TIGRFAMsiTIGR03102. halo_cynanin. 1 hit.
PROSITEiPS00196. COPPER_BLUE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39442-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDISRRRFV LGTGATVAAA TLAGCNGNGN GNGNGNGNGE PDTPEGRADQ
60 70 80 90 100
FLTDNDALMY DGDITDETGQ DEVVVVTGAG NNGFAFDPAA IRVDVGTTVT
110 120 130 140 150
WEWTGDGGAH NVVSEPESDF EFESDRVDEE GFTFEQTFDD EGVALYVCTP
160
HRAQGMYGAV IVE
Length:163
Mass (Da):17,222
Last modified:February 1, 1995 - v1
Checksum:iDB180417F8B0BEE6
GO

Mass spectrometryi

Molecular mass is 15456±1.5 Da from positions 25 - 163. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z30236 Genomic DNA. Translation: CAA82942.1.
PIRiA53792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z30236 Genomic DNA. Translation: CAA82942.1 .
PIRi A53792.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1N3D model - A 69-163 [» ]
ProteinModelPortali P39442.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 1 hit.
InterProi IPR000923. BlueCu_1.
IPR028871. BlueCu_1_BS.
IPR008972. Cupredoxin.
IPR017533. Halocyanin.
IPR006311. TAT_signal.
[Graphical view ]
Pfami PF00127. Copper-bind. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
TIGRFAMsi TIGR03102. halo_cynanin. 1 hit.
PROSITEi PS00196. COPPER_BLUE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The primary structure of halocyanin, an archaeal blue copper protein, predicts a lipid anchor for membrane fixation."
    Mattar S., Scharf B., Kent S.B.H., Rodewald K., Oesterhelt D., Engelhard M.
    J. Biol. Chem. 269:14939-14945(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, LIPIDATION AT CYS-25, ACETYLATION AT CYS-25, MASS SPECTROMETRY.
    Strain: SP-1 / 28.
  2. "Halocyanin, an archaebacterial blue copper protein (type I) from Natronobacterium pharaonis."
    Scharf B., Engelhard M.
    Biochemistry 32:12894-12900(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, PROTEIN SEQUENCE OF 144-163.

Entry informationi

Entry nameiHCY_NATPH
AccessioniPrimary (citable) accession number: P39442
Secondary accession number(s): Q9UWL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3