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P39438

- UPPP_AZOBR

UniProt

P39438 - UPPP_AZOBR

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, bacA, upk
Organism
Azospirillum brasilense
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA, upk
OrganismiAzospirillum brasilense
Taxonomic identifieri192 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeAzospirillum

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321Helical; Reviewed predictionAdd
BLAST
Transmembranei45 – 6521Helical; Reviewed predictionAdd
BLAST
Transmembranei85 – 10521Helical; Reviewed predictionAdd
BLAST
Transmembranei108 – 12821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›187›187Undecaprenyl-diphosphatasePRO_0000151083Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P39438-1 [UniParc]FASTAAdd to Basket

« Hide

MLIDQYLDAA LLGLIEGLTE FLPVSSTGHL IIFDTLLGFE GPPGKVFEVV    50
IQLGAILAIC TVYFARLWKV VTGLKDDPGA RHFAMAVILA FLPAMVLGAA 100
LHGVIKAVLF NPTVVSIALI LGGVAILMAE RLVPAPRYHQ IERFPAPLAL 150
KIGLCQCLAL VPGVSRSGAT ILGSLLMGVD RRTAAEF 187
Length:187
Mass (Da):19,842
Last modified:February 1, 1995 - v1
Checksum:iE04C8995BCFDB63A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei187 – 1871

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF192408 Genomic DNA. Translation: AAA22178.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF192408 Genomic DNA. Translation: AAA22178.2 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Glutamate synthase genes of the diazotroph Azospirillum brasilense. Cloning, sequencing, and analysis of functional domains."
    Pelanda R., Vanoni M.A., Perego M., Piubelli L., Galizzi A., Curti B., Zanetti G.
    J. Biol. Chem. 268:3099-3106(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29145 / Sp7 / DSM 1690 / IMET 11303.

Entry informationi

Entry nameiUPPP_AZOBR
AccessioniPrimary (citable) accession number: P39438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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