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P39438

- UPPP_AZOBR

UniProt

P39438 - UPPP_AZOBR

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Azospirillum brasilense
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.By similarity

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase (EC:3.6.1.27)
    Alternative name(s):
    Bacitracin resistance protein
    Undecaprenyl pyrophosphate phosphatase
    Gene namesi
    Name:uppP
    Synonyms:bacA, upk
    OrganismiAzospirillum brasilense
    Taxonomic identifieri192 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeAzospirillum

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›187›187Undecaprenyl-diphosphatasePRO_0000151083Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P39438-1 [UniParc]FASTAAdd to Basket

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    MLIDQYLDAA LLGLIEGLTE FLPVSSTGHL IIFDTLLGFE GPPGKVFEVV    50
    IQLGAILAIC TVYFARLWKV VTGLKDDPGA RHFAMAVILA FLPAMVLGAA 100
    LHGVIKAVLF NPTVVSIALI LGGVAILMAE RLVPAPRYHQ IERFPAPLAL 150
    KIGLCQCLAL VPGVSRSGAT ILGSLLMGVD RRTAAEF 187
    Length:187
    Mass (Da):19,842
    Last modified:February 1, 1995 - v1
    Checksum:iE04C8995BCFDB63A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei187 – 1871

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF192408 Genomic DNA. Translation: AAA22178.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF192408 Genomic DNA. Translation: AAA22178.2 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Glutamate synthase genes of the diazotroph Azospirillum brasilense. Cloning, sequencing, and analysis of functional domains."
      Pelanda R., Vanoni M.A., Perego M., Piubelli L., Galizzi A., Curti B., Zanetti G.
      J. Biol. Chem. 268:3099-3106(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 29145 / Sp7 / DSM 1690 / IMET 11303.

    Entry informationi

    Entry nameiUPPP_AZOBR
    AccessioniPrimary (citable) accession number: P39438
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3