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P39438 (UPPP_AZOBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
OrganismAzospirillum brasilense
Taxonomic identifier192 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeAzospirillum

Protein attributes

Sequence length187 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›187›187Undecaprenyl-diphosphatase
PRO_0000151083

Regions

Transmembrane13 – 3321Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane108 – 12821Helical; Potential

Experimental info

Non-terminal residue1871

Sequences

Sequence LengthMass (Da)Tools
P39438 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: E04C8995BCFDB63A

FASTA18719,842
        10         20         30         40         50         60 
MLIDQYLDAA LLGLIEGLTE FLPVSSTGHL IIFDTLLGFE GPPGKVFEVV IQLGAILAIC 

        70         80         90        100        110        120 
TVYFARLWKV VTGLKDDPGA RHFAMAVILA FLPAMVLGAA LHGVIKAVLF NPTVVSIALI 

       130        140        150        160        170        180 
LGGVAILMAE RLVPAPRYHQ IERFPAPLAL KIGLCQCLAL VPGVSRSGAT ILGSLLMGVD 


RRTAAEF 

« Hide

References

[1]"Glutamate synthase genes of the diazotroph Azospirillum brasilense. Cloning, sequencing, and analysis of functional domains."
Pelanda R., Vanoni M.A., Perego M., Piubelli L., Galizzi A., Curti B., Zanetti G.
J. Biol. Chem. 268:3099-3106(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 29145 / Sp7 / DSM 1690 / IMET 11303.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF192408 Genomic DNA. Translation: AAA22178.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_AZOBR
AccessionPrimary (citable) accession number: P39438
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families