Reviewed,
UniProtKB/Swiss-Prot P39428 (TRAF1_MOUSE)
Last modified
October 13, 2009.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: TNF receptor-associated factor 1 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 409 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. |
| Subunit structure | Homotrimer Probable. Heteromer with TRAF2 and associates with TNFRSF1B/TNFR2 through TRAF2. Associates with TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, TANK/ITRAF and RIPK2 By similarity. Interacts with BIRC2 and BIRC3 N-terminus By similarity. Binds TRAIP. Interacts with NFATC2IP and with HIVEP3. |
| Subcellular location | |
| Domain | The coiled coil domain mediates homo- and hetero-oligomerization. The MATH/TRAF domain binds to receptor cytoplasmic domains. |
| Sequence similarities | Contains 1 MATH domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis |
| Cellular component | Cytoplasm |
| Domain | Coiled coil |
| PTM | Phosphoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | apoptosis Inferred from electronic annotation. Source: UniProtKB-KW regulation of apoptosisInferred from electronic annotation. Source: InterPro signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Ref.1 Inferred from physical interaction. Source: IntAct zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| EDAR | Q9UNE0 | 1 | EBI-520123,EBI-529289 | From a different organism. |
| TNFRSF1B | P20333 | 1 | EBI-520123,EBI-358983 | From a different organism. |
| TNFRSF8 | P28908 | 1 | EBI-520123,EBI-529023 | From a different organism. |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor." Rothe M., Wong S.C., Henzel W.J., Goeddel D.V. Cell 78:681-692(1994) [PubMed: 8069916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 123-135 AND 390-402, INTERACTION WITH TRAF2 AND TNFRSF1B. |
| [2] | "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation." Lee S.Y., Lee S.Y., Choi Y. J. Exp. Med. 185:1275-1285(1997) [PubMed: 9104814] [Abstract] Cited for: INTERACTION WITH TRAIP. |
| [3] | "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2." Oukka M., Kim S.T., Lugo G., Sun J., Wu L.-C., Glimcher L.H. Mol. Cell 9:121-131(2002) [PubMed: 11804591] [Abstract] Cited for: INTERACTION WITH HIVEP3. |
| [4] | "TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45." Bryce P.J., Oyoshi M.K., Kawamoto S., Oettgen H.C., Tsitsikov E.N. Int. Immunol. 18:101-111(2006) [PubMed: 16352630] [Abstract] Cited for: INTERACTION WITH NFATC2IP. |
| [5] | "Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| L35302 mRNA. Translation: AAC37663.1. | |
| IPI | IPI00135899. |
| PIR | A54750. |
| UniGene | Mm.239514 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1CZY based on UniProtKB Q12933. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:260N. |
| IntAct | P39428. 5 interactions. |
| STRING | P39428. |
PTM databases | |
| PhosphoSite | P39428. |
Proteomic databases | |
| PRIDE | P39428. |
Genome annotation databases | |
| Ensembl | ENSMUST00000028234; ENSMUSP00000028234; ENSMUSG00000026875; Mus musculus. [Genome view] ENSMUST00000113064; ENSMUSP00000108687; ENSMUSG00000026875; Mus musculus. [Genome view] |
Organism-specific databases | |
| MGI | MGI:101836. Traf1. |
Phylogenomic databases | |
| HOGENOM | P39428. |
| HOVERGEN | P39428. |
Gene expression databases | |
| ArrayExpress | P39428. |
| Bgee | P39428. |
| CleanEx | MM_TRAF1. |
| Genevestigator | P39428. |
| GermOnline | ENSMUSG00000026875. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002083. MATH. IPR015448. TNF_rcpt-assoc_fac-1. IPR012227. TNF_recpt_TRAF. IPR013322. TRAF-type. [Graphical view] |
| Gene3D | G3DSA:2.60.210.10. TRAF-type. 1 hit. |
| PANTHER | PTHR10131:SF26. TRAF1. 1 hit. |
| Pfam | PF00917. MATH. 1 hit. [Graphical view] |
| PIRSF | PIRSF015614. TRAF. 1 hit. |
| SMART | SM00061. MATH. 1 hit. [Graphical view] |
| PROSITE | PS50144. MATH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | TRAF1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P39428 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


