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Protein

Toxin YjjJ

Gene

yjjJ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Toxic when overexpressed in E.coli, leading to long filamentous cells. The toxic effect is neutralized by non-cognate antitoxin HipB (PubMed:28430938). Does not seem to inhibit DNA, RNA or protein synthesis, and unlike paralogous toxin HipA its toxic activity is not counteracted by overexpression of GltX (PubMed:28430938). Binds DNA (PubMed:28430938). Might be a protein kinase (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei342Proton acceptorSequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Kinase, Toxin, Transferase

Enzyme and pathway databases

BioCyciEcoCyc:EG12342-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin YjjJ
Alternative name(s):
Putative DNA-binding transcriptional regulator YjjJ
Putative serine/threonine kinase toxin YjjJ (EC:2.-.-.-)
Gene namesi
Name:yjjJ
Ordered Locus Names:b4385, JW4348
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12342. yjjJ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001698091 – 443Toxin YjjJAdd BLAST443

Proteomic databases

PaxDbiP39410.
PRIDEiP39410.

Interactioni

Protein-protein interaction databases

BioGridi4259320. 6 interactors.
IntActiP39410. 2 interactors.
STRINGi316385.ECDH10B_4543.

Structurei

3D structure databases

ProteinModelPortaliP39410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HipA Ser/Thr kinase family.Curated

Phylogenomic databases

eggNOGiENOG4105EUP. Bacteria.
ENOG410XRIH. LUCA.
HOGENOMiHOG000127842.
InParanoidiP39410.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR012893. HipA-like_C.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF07804. HipA_C. 1 hit.

Sequencei

Sequence statusi: Complete.

P39410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELTDLLLQ GPRSAPELRQ RLAISQATFS RLVAREDRVI RFGKARATRY
60 70 80 90 100
ALLRPYRGIE RIPVWRVDDT GKAHKFADIR LCWPQGSCLV TGADGDEQWF
110 120 130 140 150
DGLPWYLTDL RPQGFLGRAW GRKLAAQLNL TDDIRLWQEE DVLYALTVFN
160 170 180 190 200
GEYTGGWLVG EGNYQRWITA QHPAEIPLDQ KLTHYEQLAS DALAGEIVGS
210 220 230 240 250
SAGGEQPKFT YYAQTPSGNK HVLVKFTVPQ QTAVSQRWGD LLIAESIAAQ
260 270 280 290 300
ILRDGGIHAI ESTVLVTSNR QVFLEAERFD CKGNDGRLPI VSLEAVQSEF
310 320 330 340 350
ISSPGSWPQA MRRLCEQQLV THQSVAQTEV IWAFGRLIAN SDMHAGNLSF
360 370 380 390 400
YLSEPPFALT PVYDMLPMVY APNSAGMLRD AAIEVKFDLN VSKSAWLTAI
410 420 430 440
PLAQQFWQTV ARDPRISEAF RHIAQEMPEK IRQIEEKVAR MGG
Length:443
Mass (Da):49,757
Last modified:February 1, 1995 - v1
Checksum:i38B78B6921CEAC91
GO

Sequence cautioni

The sequence CAA29115 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
The sequence CAA29115 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97281.1.
U00096 Genomic DNA. Translation: AAC77338.1.
AP009048 Genomic DNA. Translation: BAE78374.1.
X05629 Genomic DNA. Translation: CAA29115.1. Sequence problems.
PIRiS56609.
RefSeqiNP_418802.1. NC_000913.3.
WP_001293115.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77338; AAC77338; b4385.
BAE78374; BAE78374; BAE78374.
GeneIDi944883.
KEGGiecj:JW4348.
eco:b4385.
PATRICifig|1411691.4.peg.2300.

Similar proteinsi

Entry informationi

Entry nameiYJJJ_ECOLI
AccessioniPrimary (citable) accession number: P39410
Secondary accession number(s): Q2M5T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: August 30, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families