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Protein

Ferric iron reductase protein FhuF

Gene

fhuF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the reduction of ferric iron in cytoplasmic ferrioxamine B.

Cofactori

[2Fe-2S] clusterNote: Binds 1 [2Fe-2S] cluster.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi244 – 2441Iron-sulfur (2Fe-2S)1 Publication
Metal bindingi245 – 2451Iron-sulfur (2Fe-2S)1 Publication
Metal bindingi256 – 2561Iron-sulfur (2Fe-2S)1 Publication
Metal bindingi259 – 2591Iron-sulfur (2Fe-2S)1 Publication

GO - Molecular functioni

  • 2 iron, 2 sulfur cluster binding Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • iron assimilation Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7949-MONOMER.
ECOL316407:JW4331-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric iron reductase protein FhuF
Gene namesi
Name:fhuF
Synonyms:yjjS
Ordered Locus Names:b4367, JW4331
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12595. fhuF.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Ferric iron reductase protein FhuFPRO_0000087235Add
BLAST

Proteomic databases

PaxDbiP39405.

Expressioni

Inductioni

Induced 2.4-fold by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262784. 6 interactions.
DIPiDIP-9607N.
IntActiP39405. 18 interactions.
STRINGi511145.b4367.

Structurei

3D structure databases

ProteinModelPortaliP39405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108819. Bacteria.
COG4114. LUCA.
HOGENOMiHOG000127617.
KOiK13255.
OMAiSPEHFHV.

Family and domain databases

InterProiIPR008090. Fe_iron_reduct.
IPR024726. FhuF_C.
IPR022770. FhuF_domain.
[Graphical view]
PfamiPF06276. FhuF. 1 hit.
PF11575. FhuF_C. 1 hit.
[Graphical view]
PRINTSiPR01714. 2FE2SRDCTASE.
TIGRFAMsiTIGR03951. Fe_III_red_FhuF. 1 hit.

Sequencei

Sequence statusi: Complete.

P39405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYRSAPLYE DVIWRTHLQP QDPTLAQAVR ATIAKHREHL LEFIRLDEPA
60 70 80 90 100
PLNAMTLAQW SSPNVLSSLL AVYSDHIYRN QPMMIRENKP LISLWAQWYI
110 120 130 140 150
GLMVPPLMLA LLTQEKALDV SPEHFHAEFH ETGRVACFWV DVCEDKNATP
160 170 180 190 200
HSPQHRMETL ISQALVPVVQ ALEATGEING KLIWSNTGYL INWYLTEMKQ
210 220 230 240 250
LLGEATVESL RHALFFEKTL TNGEDNPLWR TVVLRDGLLV RRTCCQRYRL
260
PDVQQCGDCT LK
Length:262
Mass (Da):30,113
Last modified:February 1, 1995 - v1
Checksum:i7708E776B1BE7783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97266.1.
U00096 Genomic DNA. Translation: AAC77323.1.
AP009048 Genomic DNA. Translation: BAE78357.1.
PIRiS56594.
RefSeqiNP_418787.1. NC_000913.3.
WP_000331618.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77323; AAC77323; b4367.
BAE78357; BAE78357; BAE78357.
GeneIDi948891.
KEGGiecj:JW4331.
eco:b4367.
PATRICi32124342. VBIEscCol129921_4514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97266.1.
U00096 Genomic DNA. Translation: AAC77323.1.
AP009048 Genomic DNA. Translation: BAE78357.1.
PIRiS56594.
RefSeqiNP_418787.1. NC_000913.3.
WP_000331618.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262784. 6 interactions.
DIPiDIP-9607N.
IntActiP39405. 18 interactions.
STRINGi511145.b4367.

Proteomic databases

PaxDbiP39405.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77323; AAC77323; b4367.
BAE78357; BAE78357; BAE78357.
GeneIDi948891.
KEGGiecj:JW4331.
eco:b4367.
PATRICi32124342. VBIEscCol129921_4514.

Organism-specific databases

EchoBASEiEB2480.
EcoGeneiEG12595. fhuF.

Phylogenomic databases

eggNOGiENOG4108819. Bacteria.
COG4114. LUCA.
HOGENOMiHOG000127617.
KOiK13255.
OMAiSPEHFHV.

Enzyme and pathway databases

BioCyciEcoCyc:G7949-MONOMER.
ECOL316407:JW4331-MONOMER.

Miscellaneous databases

PROiP39405.

Family and domain databases

InterProiIPR008090. Fe_iron_reduct.
IPR024726. FhuF_C.
IPR022770. FhuF_domain.
[Graphical view]
PfamiPF06276. FhuF. 1 hit.
PF11575. FhuF_C. 1 hit.
[Graphical view]
PRINTSiPR01714. 2FE2SRDCTASE.
TIGRFAMsiTIGR03951. Fe_III_red_FhuF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFHUF_ECOLI
AccessioniPrimary (citable) accession number: P39405
Secondary accession number(s): Q2M5U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.