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Protein

Phosphoglycerol transferase I

Gene

mdoB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.2 Publications

Catalytic activityi

Phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose.

Pathwayi: osmoregulated periplasmic glucan (OPG) biosynthesis

This protein is involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis and in Glycan metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciEcoCyc:PGLYCEROLTRANSI-MONOMER.
ECOL316407:JW5794-MONOMER.
MetaCyc:PGLYCEROLTRANSI-MONOMER.
UniPathwayiUPA00637.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerol transferase I (EC:2.7.8.20)
Alternative name(s):
Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase
Gene namesi
Name:mdoB
Synonyms:opgB, yjjO
Ordered Locus Names:b4359, JW5794
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12591. mdoB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence analysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: EcoCyc
  • periplasmic space Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Phosphoglycerol transferase IPRO_0000213059Add
BLAST

Proteomic databases

PaxDbiP39401.
PRIDEiP39401.

Interactioni

Protein-protein interaction databases

BioGridi4261390. 163 interactions.
DIPiDIP-10175N.
IntActiP39401. 1 interaction.
MINTiMINT-1305397.
STRINGi511145.b4359.

Structurei

3D structure databases

ProteinModelPortaliP39401.
SMRiP39401. Positions 129-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OpgB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107RES. Bacteria.
COG1368. LUCA.
HOGENOMiHOG000127573.
KOiK01002.
OMAiSPWFKNT.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
HAMAPiMF_01070. MdoB_OpgB. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR020881. Phosphoglycerol_transferase_I.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.

Sequencei

Sequence statusi: Complete.

P39401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELLSFALF LASVLIYAWK AGRNTWWFAA TLTVLGLFVV LNITLFASDY
60 70 80 90 100
FTGDGINDAV LYTLTNSLTG AGVSKYILPG IGIVLGLTAV FGALGWILRR
110 120 130 140 150
RRHHPHHFGY SLLALLLALG SVDASPAFRQ ITELVKSQSR DGDPDFAAYY
160 170 180 190 200
KEPSKTIPDP KLNLVYIYGE SLERTYFDNE AFPDLTPELG ALKNEGLDFS
210 220 230 240 250
HTQQLPGTDY TIAGMVASQC GIPLFAPFEG NASASVSSFF PQNICLGDIL
260 270 280 290 300
KNSGYQNYFV QGANLRFAGK DVFLKSHGFD HLYGSEELKS VVADPHYRND
310 320 330 340 350
WGFYDDTVLD EAWKKFEELS RSGQRFSLFT LTVDTHHPDG FISRTCNRKK
360 370 380 390 400
YDFDGKPNQS FSAVSCSQEN IATFINKIKA SPWFKDTVIV VSSDHLAMNN
410 420 430 440 450
TAWKYLNKQD RNNLFFVIRG DKPQQETLAV KRNTMDNGAT VLDILGGDNY
460 470 480 490 500
LGLGRSSLSG QSMSEIFLNI KEKTLAWKPD IIRLWKFPKE MKEFTIDQQK
510 520 530 540 550
NMIAFSGSHF RLPLLLRVSD KRVEPLPESE YSAPLRFQLA DFAPRDNFVW
560 570 580 590 600
VDRCYKMAQL WAPELALSTD WCVSQGQLGG QQIVQHVDKT TWQGKTAFKD
610 620 630 640 650
TVIDMARYKG NVDTLKIVDN DIRYKADSFI FNVAGAPEEV KQFSGISRPE
660 670 680 690 700
SWGRWSNAQL GDEVKIEYKH PLPKKFDLVI TAKAYGNNAS RPIPVRVGNE
710 720 730 740 750
EQTLVLGNEV TTTTLHFDNP TDADTLVIVP PEPVSTNEGN ILGHSPRKLG
760
IGMVEIKVVE REG
Length:763
Mass (Da):85,494
Last modified:July 11, 2001 - v2
Checksum:i4F6C46DE859E7D65
GO

Sequence cautioni

The sequence AAA97258 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97258.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77315.2.
AP009048 Genomic DNA. Translation: BAE78349.1.
PIRiS56586.
RefSeqiNP_418779.2. NC_000913.3.
WP_001292679.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77315; AAC77315; b4359.
BAE78349; BAE78349; BAE78349.
GeneIDi948888.
KEGGiecj:JW5794.
eco:b4359.
PATRICi32124326. VBIEscCol129921_4506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97258.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77315.2.
AP009048 Genomic DNA. Translation: BAE78349.1.
PIRiS56586.
RefSeqiNP_418779.2. NC_000913.3.
WP_001292679.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39401.
SMRiP39401. Positions 129-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261390. 163 interactions.
DIPiDIP-10175N.
IntActiP39401. 1 interaction.
MINTiMINT-1305397.
STRINGi511145.b4359.

Proteomic databases

PaxDbiP39401.
PRIDEiP39401.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77315; AAC77315; b4359.
BAE78349; BAE78349; BAE78349.
GeneIDi948888.
KEGGiecj:JW5794.
eco:b4359.
PATRICi32124326. VBIEscCol129921_4506.

Organism-specific databases

EchoBASEiEB2476.
EcoGeneiEG12591. mdoB.

Phylogenomic databases

eggNOGiENOG4107RES. Bacteria.
COG1368. LUCA.
HOGENOMiHOG000127573.
KOiK01002.
OMAiSPWFKNT.

Enzyme and pathway databases

UniPathwayiUPA00637.
BioCyciEcoCyc:PGLYCEROLTRANSI-MONOMER.
ECOL316407:JW5794-MONOMER.
MetaCyc:PGLYCEROLTRANSI-MONOMER.

Miscellaneous databases

PROiP39401.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
HAMAPiMF_01070. MdoB_OpgB. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR020881. Phosphoglycerol_transferase_I.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOPGB_ECOLI
AccessioniPrimary (citable) accession number: P39401
Secondary accession number(s): Q2M5V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 11, 2001
Last modified: September 7, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.