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Protein

Phosphoglycerol transferase I

Gene

mdoB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.2 Publications

Catalytic activityi

Phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose.

Pathwayi: osmoregulated periplasmic glucan (OPG) biosynthesis

This protein is involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis and in Glycan metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciEcoCyc:PGLYCEROLTRANSI-MONOMER
MetaCyc:PGLYCEROLTRANSI-MONOMER
UniPathwayiUPA00637

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerol transferase I (EC:2.7.8.20)
Alternative name(s):
Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase
Gene namesi
Name:mdoB
Synonyms:opgB, yjjO
Ordered Locus Names:b4359, JW5794
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12591 mdoB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: EcoCyc
  • periplasmic space Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002130591 – 763Phosphoglycerol transferase IAdd BLAST763

Proteomic databases

PaxDbiP39401
PRIDEiP39401

Interactioni

Protein-protein interaction databases

BioGridi4261390, 165 interactors
DIPiDIP-10175N
IntActiP39401, 1 interactor
STRINGi316407.85677099

Structurei

3D structure databases

ProteinModelPortaliP39401
SMRiP39401
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OpgB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107RES Bacteria
COG1368 LUCA
HOGENOMiHOG000127573
KOiK01002
OMAiSPWFKNT

Family and domain databases

Gene3Di3.40.720.10, 1 hit
HAMAPiMF_01070 MdoB_OpgB, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR020881 Phosphoglycerol_transferase_I
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit

Sequencei

Sequence statusi: Complete.

P39401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELLSFALF LASVLIYAWK AGRNTWWFAA TLTVLGLFVV LNITLFASDY
60 70 80 90 100
FTGDGINDAV LYTLTNSLTG AGVSKYILPG IGIVLGLTAV FGALGWILRR
110 120 130 140 150
RRHHPHHFGY SLLALLLALG SVDASPAFRQ ITELVKSQSR DGDPDFAAYY
160 170 180 190 200
KEPSKTIPDP KLNLVYIYGE SLERTYFDNE AFPDLTPELG ALKNEGLDFS
210 220 230 240 250
HTQQLPGTDY TIAGMVASQC GIPLFAPFEG NASASVSSFF PQNICLGDIL
260 270 280 290 300
KNSGYQNYFV QGANLRFAGK DVFLKSHGFD HLYGSEELKS VVADPHYRND
310 320 330 340 350
WGFYDDTVLD EAWKKFEELS RSGQRFSLFT LTVDTHHPDG FISRTCNRKK
360 370 380 390 400
YDFDGKPNQS FSAVSCSQEN IATFINKIKA SPWFKDTVIV VSSDHLAMNN
410 420 430 440 450
TAWKYLNKQD RNNLFFVIRG DKPQQETLAV KRNTMDNGAT VLDILGGDNY
460 470 480 490 500
LGLGRSSLSG QSMSEIFLNI KEKTLAWKPD IIRLWKFPKE MKEFTIDQQK
510 520 530 540 550
NMIAFSGSHF RLPLLLRVSD KRVEPLPESE YSAPLRFQLA DFAPRDNFVW
560 570 580 590 600
VDRCYKMAQL WAPELALSTD WCVSQGQLGG QQIVQHVDKT TWQGKTAFKD
610 620 630 640 650
TVIDMARYKG NVDTLKIVDN DIRYKADSFI FNVAGAPEEV KQFSGISRPE
660 670 680 690 700
SWGRWSNAQL GDEVKIEYKH PLPKKFDLVI TAKAYGNNAS RPIPVRVGNE
710 720 730 740 750
EQTLVLGNEV TTTTLHFDNP TDADTLVIVP PEPVSTNEGN ILGHSPRKLG
760
IGMVEIKVVE REG
Length:763
Mass (Da):85,494
Last modified:July 11, 2001 - v2
Checksum:i4F6C46DE859E7D65
GO

Sequence cautioni

The sequence AAA97258 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97258.1 Different initiation.
U00096 Genomic DNA Translation: AAC77315.2
AP009048 Genomic DNA Translation: BAE78349.1
PIRiS56586
RefSeqiNP_418779.2, NC_000913.3
WP_001292679.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77315; AAC77315; b4359
BAE78349; BAE78349; BAE78349
GeneIDi948888
KEGGiecj:JW5794
eco:b4359
PATRICifig|1411691.4.peg.2327

Similar proteinsi

Entry informationi

Entry nameiOPGB_ECOLI
AccessioniPrimary (citable) accession number: P39401
Secondary accession number(s): Q2M5V7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 11, 2001
Last modified: March 28, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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