Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable HTH-type transcriptional regulator LgoR

Gene

lgoR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a positive transcriptional regulator for lgoD and/or lgoT. Is essential for growth on L-galactonate as the sole carbon source.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi31 – 50H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • galactonate catabolic process Source: EcoCyc
  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7944-MONOMER.
ECOL316407:JW5792-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable HTH-type transcriptional regulator LgoR
Gene namesi
Name:lgoRImported
Synonyms:yjjM
Ordered Locus Names:b4357, JW5792
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12589. lgoR.

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene fail to grow on L-galactonate as sole carbon source.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001698101 – 304Probable HTH-type transcriptional regulator LgoRAdd BLAST304

Proteomic databases

PaxDbiP39399.
PRIDEiP39399.

Expressioni

Inductioni

Highly up-regulated during growth on L-galactonate.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261391. 99 interactors.
STRINGi511145.b4357.

Structurei

3D structure databases

ProteinModelPortaliP39399.
SMRiP39399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 70HTH gntR-typeAdd BLAST70

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410617M. Bacteria.
COG1802. LUCA.
HOGENOMiHOG000127562.
OMAiREMFELH.
PhylomeDBiP39399.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
SSF48008. SSF48008. 1 hit.

Sequencei

Sequence statusi: Complete.

P39399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSQNLRHN VINQVIDDMA RGHIPSPLPS QSALAEMYNI SRTTVRHILS
60 70 80 90 100
HLRECGVLTQ VGNDYVIARK PDHDDGFACT TASMSEQNKV FEQAFFTMIN
110 120 130 140 150
QRQLRPGETF SELQLARAAG VSPVVVREYL LKFGRYNLIH SEKRGQWSMK
160 170 180 190 200
QFDQSYAEQL FELREMLETH SLQHFLNLPD HDPRWLQAKT MLERHRLLRD
210 220 230 240 250
NIGNSFRMFS QLDRDFHSLL LSAADNIFFD QSLEIISVIF HFHYQWDESD
260 270 280 290 300
LKQRNIIAVD EHMTILSALI CRSDLDATLA LRNHLNSAKQ SMIRSINENT

RYAH
Length:304
Mass (Da):35,397
Last modified:October 11, 2004 - v2
Checksum:iA41399D07F0DA9C7
GO

Sequence cautioni

The sequence AAA97255 differs from that shown. Reason: Frameshift at position 29.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56G → A in AAA97255 (PubMed:7610040).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97255.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48248.1.
AP009048 Genomic DNA. Translation: BAE78347.1.
PIRiS56584.
RefSeqiWP_000091570.1. NZ_LN832404.1.
YP_026290.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48248; AAT48248; b4357.
BAE78347; BAE78347; BAE78347.
GeneIDi948881.
KEGGiecj:JW5792.
eco:b4357.
PATRICi32124320. VBIEscCol129921_4503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97255.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48248.1.
AP009048 Genomic DNA. Translation: BAE78347.1.
PIRiS56584.
RefSeqiWP_000091570.1. NZ_LN832404.1.
YP_026290.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP39399.
SMRiP39399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261391. 99 interactors.
STRINGi511145.b4357.

Proteomic databases

PaxDbiP39399.
PRIDEiP39399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48248; AAT48248; b4357.
BAE78347; BAE78347; BAE78347.
GeneIDi948881.
KEGGiecj:JW5792.
eco:b4357.
PATRICi32124320. VBIEscCol129921_4503.

Organism-specific databases

EchoBASEiEB2474.
EcoGeneiEG12589. lgoR.

Phylogenomic databases

eggNOGiENOG410617M. Bacteria.
COG1802. LUCA.
HOGENOMiHOG000127562.
OMAiREMFELH.
PhylomeDBiP39399.

Enzyme and pathway databases

BioCyciEcoCyc:G7944-MONOMER.
ECOL316407:JW5792-MONOMER.

Miscellaneous databases

PROiP39399.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
SSF48008. SSF48008. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLGOR_ECOLI
AccessioniPrimary (citable) accession number: P39399
Secondary accession number(s): Q2M5V9, Q6BEW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.