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Protein

Probable HTH-type transcriptional regulator LgoR

Gene

lgoR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a positive transcriptional regulator for lgoD and/or lgoT. Is essential for growth on L-galactonate as the sole carbon source.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi31 – 50H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • galactonate catabolic process Source: EcoCyc
  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7944-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable HTH-type transcriptional regulator LgoR
Gene namesi
Name:lgoRImported
Synonyms:yjjM
Ordered Locus Names:b4357, JW5792
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12589 lgoR

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene fail to grow on L-galactonate as sole carbon source.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001698101 – 304Probable HTH-type transcriptional regulator LgoRAdd BLAST304

Proteomic databases

PaxDbiP39399
PRIDEiP39399

Expressioni

Inductioni

Highly up-regulated during growth on L-galactonate.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261391, 99 interactors
STRINGi316407.85677097

Structurei

3D structure databases

ProteinModelPortaliP39399
SMRiP39399
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 70HTH gntR-typeAdd BLAST70

Phylogenomic databases

eggNOGiENOG410617M Bacteria
COG1802 LUCA
HOGENOMiHOG000127562
OMAiREMFELH
PhylomeDBiP39399

Family and domain databases

Gene3Di1.10.10.10, 2 hits
1.20.120.530, 1 hit
InterProiView protein in InterPro
IPR011711 GntR_C
IPR008920 TF_FadR/GntR_C
IPR000524 Tscrpt_reg_HTH_GntR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF07729 FCD, 1 hit
PF00392 GntR, 1 hit
PRINTSiPR00035 HTHGNTR
SMARTiView protein in SMART
SM00895 FCD, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits
SSF48008 SSF48008, 1 hit

Sequencei

Sequence statusi: Complete.

P39399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSQNLRHN VINQVIDDMA RGHIPSPLPS QSALAEMYNI SRTTVRHILS
60 70 80 90 100
HLRECGVLTQ VGNDYVIARK PDHDDGFACT TASMSEQNKV FEQAFFTMIN
110 120 130 140 150
QRQLRPGETF SELQLARAAG VSPVVVREYL LKFGRYNLIH SEKRGQWSMK
160 170 180 190 200
QFDQSYAEQL FELREMLETH SLQHFLNLPD HDPRWLQAKT MLERHRLLRD
210 220 230 240 250
NIGNSFRMFS QLDRDFHSLL LSAADNIFFD QSLEIISVIF HFHYQWDESD
260 270 280 290 300
LKQRNIIAVD EHMTILSALI CRSDLDATLA LRNHLNSAKQ SMIRSINENT

RYAH
Length:304
Mass (Da):35,397
Last modified:October 11, 2004 - v2
Checksum:iA41399D07F0DA9C7
GO

Sequence cautioni

The sequence AAA97255 differs from that shown. Reason: Frameshift at position 29.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56G → A in AAA97255 (PubMed:7610040).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97255.1 Frameshift.
U00096 Genomic DNA Translation: AAT48248.1
AP009048 Genomic DNA Translation: BAE78347.1
PIRiS56584
RefSeqiWP_000091570.1, NZ_LN832404.1
YP_026290.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48248; AAT48248; b4357
BAE78347; BAE78347; BAE78347
GeneIDi948881
KEGGiecj:JW5792
eco:b4357
PATRICifig|1411691.4.peg.2329

Similar proteinsi

Entry informationi

Entry nameiLGOR_ECOLI
AccessioniPrimary (citable) accession number: P39399
Secondary accession number(s): Q2M5V9, Q6BEW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health