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Protein

Probable L-galactonate transporter

Gene

lgoT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L-galactonate as the sole carbon source.1 Publication

GO - Molecular functioni

GO - Biological processi

  • aldonate transport Source: EcoCyc
  • transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YJIZ-MONOMER.
ECOL316407:JW4319-MONOMER.
MetaCyc:YJIZ-MONOMER.

Protein family/group databases

TCDBi2.A.1.14.33. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-galactonate transporter
Alternative name(s):
Galactonate:H(+) symporter
Gene namesi
Name:lgoTImported
Synonyms:yjiZ, yjjL
Ordered Locus Names:b4356, JW4319
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12588. lgoT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242PeriplasmicSequence analysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Topological domaini64 – 718CytoplasmicSequence analysis
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Topological domaini93 – 10715PeriplasmicSequence analysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Topological domaini129 – 17446CytoplasmicSequence analysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST
Topological domaini196 – 1961PeriplasmicSequence analysis
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Topological domaini218 – 25942CytoplasmicSequence analysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence analysisAdd
BLAST
Topological domaini281 – 29515PeriplasmicSequence analysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence analysisAdd
BLAST
Topological domaini317 – 33216CytoplasmicSequence analysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence analysisAdd
BLAST
Topological domaini354 – 3596PeriplasmicSequence analysis
Transmembranei360 – 38021HelicalSequence analysisAdd
BLAST
Topological domaini381 – 39414CytoplasmicSequence analysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence analysisAdd
BLAST
Topological domaini416 – 4227PeriplasmicSequence analysis
Transmembranei423 – 44321HelicalSequence analysisAdd
BLAST
Topological domaini444 – 45310Cytoplasmic1 Publication

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene fail to grow on L-galactonate as sole carbon source.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Probable L-galactonate transporterPRO_0000121391Add
BLAST

Proteomic databases

PaxDbiP39398.
PRIDEiP39398.

Expressioni

Inductioni

Highly up-regulated during growth on L-galactonate.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262773. 112 interactions.
DIPiDIP-12656N.
IntActiP39398. 1 interaction.
MINTiMINT-1309486.
STRINGi511145.b4356.

Structurei

3D structure databases

ProteinModelPortaliP39398.
SMRiP39398. Positions 37-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108I5G. Bacteria.
ENOG410XRW2. LUCA.
HOGENOMiHOG000113641.
InParanoidiP39398.
OMAiRVAFLTI.
PhylomeDBiP39398.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKENITIDP RSSFTPSSSA DIPVPPDGLV QRSTRIKRIQ TTAMLLLFFA
60 70 80 90 100
AVINYLDRSS LSVANLTIRE ELGLSATEIG ALLSVFSLAY GIAQLPCGPL
110 120 130 140 150
LDRKGPRLML GLGMFFWSLF QAMSGMVHNF TQFVLVRIGM GIGEAPMNPC
160 170 180 190 200
GVKVINDWFN IKERGRPMGF FNAASTIGVA VSPPILAAMM LVMGWRGMFI
210 220 230 240 250
TIGVLGIFLA IGWYMLYRNR EHVELTAVEQ AYLNAGSVNA RRDPLSFAEW
260 270 280 290 300
RSLFRNRTMW GMMLGFSGIN YTAWLYLAWL PGYLQTAYNL DLKSTGLMAA
310 320 330 340 350
IPFLFGAAGM LVNGYVTDWL VKGGMAPIKS RKICIIAGMF CSAAFTLIVP
360 370 380 390 400
QATTSMTAVL LIGMALFCIH FAGTSCWGLI HVAVASRMTA SVGSIQNFAS
410 420 430 440 450
FICASFAPII TGFIVDTTHS FRLALIICGC VTAAGALAYI FLVRQPINDP

RKD
Length:453
Mass (Da):49,440
Last modified:July 15, 1998 - v2
Checksum:i43156D106B7FCFFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97254.1. Frameshift.
U14003 Genomic DNA. Translation: AAA97253.1. Frameshift.
U00096 Genomic DNA. Translation: AAC77312.1.
AP009048 Genomic DNA. Translation: BAE78346.1.
PIRiF65250.
S56583.
RefSeqiNP_418776.1. NC_000913.3.
WP_000410113.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77312; AAC77312; b4356.
BAE78346; BAE78346; BAE78346.
GeneIDi948879.
KEGGiecj:JW4319.
eco:b4356.
PATRICi32124318. VBIEscCol129921_4502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97254.1. Frameshift.
U14003 Genomic DNA. Translation: AAA97253.1. Frameshift.
U00096 Genomic DNA. Translation: AAC77312.1.
AP009048 Genomic DNA. Translation: BAE78346.1.
PIRiF65250.
S56583.
RefSeqiNP_418776.1. NC_000913.3.
WP_000410113.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39398.
SMRiP39398. Positions 37-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262773. 112 interactions.
DIPiDIP-12656N.
IntActiP39398. 1 interaction.
MINTiMINT-1309486.
STRINGi511145.b4356.

Protein family/group databases

TCDBi2.A.1.14.33. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP39398.
PRIDEiP39398.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77312; AAC77312; b4356.
BAE78346; BAE78346; BAE78346.
GeneIDi948879.
KEGGiecj:JW4319.
eco:b4356.
PATRICi32124318. VBIEscCol129921_4502.

Organism-specific databases

EchoBASEiEB2473.
EcoGeneiEG12588. lgoT.

Phylogenomic databases

eggNOGiENOG4108I5G. Bacteria.
ENOG410XRW2. LUCA.
HOGENOMiHOG000113641.
InParanoidiP39398.
OMAiRVAFLTI.
PhylomeDBiP39398.

Enzyme and pathway databases

BioCyciEcoCyc:YJIZ-MONOMER.
ECOL316407:JW4319-MONOMER.
MetaCyc:YJIZ-MONOMER.

Miscellaneous databases

PROiP39398.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLGOT_ECOLI
AccessioniPrimary (citable) accession number: P39398
Secondary accession number(s): P39397, Q2M5W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.