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Protein

Inner membrane protein YjiY

Gene

yjiY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • cellular response to nutrient levels Source: EcoCyc
  • cellular response to starvation Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7942-MONOMER.
ECOL316407:JW5791-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane protein YjiY
Gene namesi
Name:yjiY
Ordered Locus Names:b4354, JW5791
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12586. yjiY.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55PeriplasmicSequence analysis
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Topological domaini27 – 304CytoplasmicSequence analysis
Transmembranei31 – 5121HelicalSequence analysisAdd
BLAST
Topological domaini52 – 8837PeriplasmicSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Topological domaini110 – 11910CytoplasmicSequence analysis
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Topological domaini141 – 16323PeriplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 1917CytoplasmicSequence analysis
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Topological domaini213 – 22210PeriplasmicSequence analysis
Transmembranei223 – 24321HelicalSequence analysisAdd
BLAST
Topological domaini244 – 25714CytoplasmicSequence analysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Topological domaini279 – 2824PeriplasmicSequence analysis
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST
Topological domaini304 – 32623CytoplasmicSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Topological domaini348 – 37427PeriplasmicSequence analysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence analysisAdd
BLAST
Topological domaini396 – 46368CytoplasmicSequence analysisAdd
BLAST
Transmembranei464 – 48421HelicalSequence analysisAdd
BLAST
Topological domaini485 – 4851PeriplasmicSequence analysis
Transmembranei486 – 50621HelicalSequence analysisAdd
BLAST
Topological domaini507 – 53125CytoplasmicSequence analysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence analysisAdd
BLAST
Topological domaini553 – 56816PeriplasmicSequence analysisAdd
BLAST
Transmembranei569 – 58921HelicalSequence analysisAdd
BLAST
Topological domaini590 – 5967CytoplasmicSequence analysis
Transmembranei597 – 61721HelicalSequence analysisAdd
BLAST
Topological domaini618 – 66851PeriplasmicSequence analysisAdd
BLAST
Transmembranei669 – 68921HelicalSequence analysisAdd
BLAST
Topological domaini690 – 71627CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Inner membrane protein YjiYPRO_0000190050Add
BLAST

Proteomic databases

PaxDbiP39396.

Expressioni

Inductioni

Strongly induced at the onset of the stationary-growth phase. Expression is dependent on the YehU/YehT two-component regulatory system, and on cAMP and the cAMP receptor protein (CRP). Repressed by LeuO. Monocistronic operon.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4261745. 182 interactions.
DIPiDIP-12649N.
IntActiP39396. 1 interaction.
STRINGi511145.b4354.

Structurei

3D structure databases

ProteinModelPortaliP39396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CstA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D22. Bacteria.
COG1966. LUCA.
HOGENOMiHOG000220271.
InParanoidiP39396.
OMAiKRTKYIW.
OrthoDBiEOG6H1PW0.
PhylomeDBiP39396.

Family and domain databases

InterProiIPR025299. CstA_C.
IPR003706. CstA_N.
[Graphical view]
PfamiPF02554. CstA. 1 hit.
PF13722. CstA_5TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P39396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTKKIFKHI PWVILGIIGA FCLAVVALRR GEHISALWIV VASVSVYLVA
60 70 80 90 100
YRYYSLYIAQ KVMKLDPTRA TPAVINNDGL NYVPTNRYVL FGHHFAAIAG
110 120 130 140 150
AGPLVGPVLA AQMGYLPGTL WLLAGVVLAG AVQDFMVLFI SSRRNGASLG
160 170 180 190 200
EMIKEEMGPV PGTIALFGCF LIMIIILAVL ALIVVKALAE SPWGVFTVCS
210 220 230 240 250
TVPIALFMGI YMRFIRPGRV GEVSVIGIVL LVASIYFGGV IAHDPYWGPA
260 270 280 290 300
LTFKDTTITF ALIGYAFVSA LLPVWLILAP RDYLATFLKI GVIVGLALGI
310 320 330 340 350
VVLNPELKMP AMTQYIDGTG PLWKGALFPF LFITIACGAV SGFHALISSG
360 370 380 390 400
TTPKLLANET DARFIGYGAM LMESFVAIMA LVAASIIEPG LYFAMNTPPA
410 420 430 440 450
GLGITMPNLH EMGGENAPII MAQLKDVTAH AAATVSSWGF VISPEQILQT
460 470 480 490 500
AKDIGEPSVL NRAGGAPTLA VGIAHVFHKV LPMADMGFWY HFGILFEALF
510 520 530 540 550
ILTALDAGTR SGRFMLQDLL GNFIPFLKKT DSLVAGIIGT AGCVGLWGYL
560 570 580 590 600
LYQGVVDPLG GVKSLWPLFG ISNQMLAAVA LVLGTVVLIK MKRTQYIWVT
610 620 630 640 650
VVPAVWLLIC TTWALGLKLF STNPQMEGFF YMASQYKEKI ANGTDLTAQQ
660 670 680 690 700
IANMNHIVVN NYTNAGLSIL FLIVVYSIIF YGFKTWLAVR NSDKRTDKET
710
PYVPIPEGGV KISSHH
Length:716
Mass (Da):77,324
Last modified:November 13, 2007 - v2
Checksum:i664E7B6169F15B4D
GO

Sequence cautioni

The sequence AAA97251.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97251.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77310.2.
AP009048 Genomic DNA. Translation: BAE78344.1.
PIRiS56580.
RefSeqiNP_418774.2. NC_000913.3.
WP_001299714.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77310; AAC77310; b4354.
BAE78344; BAE78344; BAE78344.
GeneIDi948914.
KEGGiecj:JW5791.
eco:b4354.
PATRICi32124314. VBIEscCol129921_4500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97251.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77310.2.
AP009048 Genomic DNA. Translation: BAE78344.1.
PIRiS56580.
RefSeqiNP_418774.2. NC_000913.3.
WP_001299714.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP39396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261745. 182 interactions.
DIPiDIP-12649N.
IntActiP39396. 1 interaction.
STRINGi511145.b4354.

Proteomic databases

PaxDbiP39396.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77310; AAC77310; b4354.
BAE78344; BAE78344; BAE78344.
GeneIDi948914.
KEGGiecj:JW5791.
eco:b4354.
PATRICi32124314. VBIEscCol129921_4500.

Organism-specific databases

EchoBASEiEB2472.
EcoGeneiEG12586. yjiY.

Phylogenomic databases

eggNOGiENOG4105D22. Bacteria.
COG1966. LUCA.
HOGENOMiHOG000220271.
InParanoidiP39396.
OMAiKRTKYIW.
OrthoDBiEOG6H1PW0.
PhylomeDBiP39396.

Enzyme and pathway databases

BioCyciEcoCyc:G7942-MONOMER.
ECOL316407:JW5791-MONOMER.

Miscellaneous databases

PROiP39396.

Family and domain databases

InterProiIPR025299. CstA_C.
IPR003706. CstA_N.
[Graphical view]
PfamiPF02554. CstA. 1 hit.
PF13722. CstA_5TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux."
    Shimada T., Yamamoto K., Ishihama A.
    J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: OPERON STRUCTURE, INDUCTION.
    Strain: K12 / BW25113.
  6. "First insights into the unexplored two-component system YehU/YehT in Escherichia coli."
    Kraxenberger T., Fried L., Behr S., Jung K.
    J. Bacteriol. 194:4272-4284(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYJIY_ECOLI
AccessioniPrimary (citable) accession number: P39396
Secondary accession number(s): Q2M5W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 13, 2007
Last modified: January 20, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.